Protective Effect of Beraprost Sodium Tablets on Reperfusion Therapy for Acute STEMI
Study Details
Study Description
Brief Summary
Protective effect of Beraprost Sodium Tablets on coronary microcirculation function and ventricular remodeling after reperfusion therapy for acute ST segment elevation myocardial infarction
Condition or Disease | Intervention/Treatment | Phase |
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Early Phase 1 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Beraprost Sodium Tablets
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Drug: Beraprost Sodium Tablets
Protective effect of Beraprost Sodium Tablets on coronary microcirculation function and ventricular remodeling after reperfusion therapy for acute ST segment elevation myocardial infarction
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Outcome Measures
Primary Outcome Measures
- Major Adverse Cardiovascular Events [1 weeks after baseline]
The incidence of mace after 1 week of treatment
- Major Adverse Cardiovascular Events [6 months after baseline]
The incidence of mace after 6 months of treatment
- Major Adverse Cardiovascular Events [1 year after baseline]
The incidence of mace after 1 year of treatment
Eligibility Criteria
Criteria
Inclusion Criteria:
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It meets the diagnostic criteria of acute ST segment elevation myocardial infarction: ischemic chest pain lasts for more than 30 minutes and can not be relieved by taking nitroglycerin; ST segment elevation of ECG with two or more adjacent leads, limb lead ≥ 1mm, chest lead ≥ 2mm; Or new left bundle branch block; The serum markers of myocardial necrosis increased at least twice the normal value
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Acute myocardial infarction was confirmed by coronary angiography
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The clinical and angiographic data were complete
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Direct PCI was performed within 12 hours after onset
Exclusion Criteria:
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Those who do not cooperate in the inspection, have poor compliance and cannot guarantee the completion of the test
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Conscious disorder, obvious intellectual disorder and mental disorder
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With metal foreign bodies, such as metal prosthesis, intraocular metal foreign bodies, intracranial aneurysm clamp, etc
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People with claustrophobia
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Had a history of myocardial infarction, PCI and coronary artery bypass grafting
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Factors affecting ST segment changes of ECG: complete left bundle branch block, preexcitation syndrome, pacemaker ECG, etc
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Shenzhen People' S Hospital | Shenzhen | Guangdong | China | 518000 |
Sponsors and Collaborators
- Shenzhen People's Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Beraprost Sodium treat STEMI