Establishing Automatic Method of Counting and Classify Bone Marrow and Peripheral Blood Cells

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT04551235
Collaborator
National Taiwan University Tai-Chen Cell Therapy Center, Biomdcare Corporation (Other)
900
1
40.1
22.5

Study Details

Study Description

Brief Summary

Counting and classification of blood cells in a bone marrow smear and peripheral blood smear are essential to clinical hematology. To this date, this procedure has been carried out in a manual manner in the great majority of clinical settings. There is often inconsistency in the counting result between different operators largely due to its manual nature. There has not been an effective and standard method for blood smear preparation and automatic counting and classification. The recent advent of deep neural network for medical image processing introduced new opportunities for an effective solution of this long-standing problem. Numerous results have been published on the effectiveness of convolutional neural network in clinical image recognition task.

Condition or Disease Intervention/Treatment Phase
  • Other: there are not any interventions in this study

Study Design

Study Type:
Observational
Anticipated Enrollment :
900 participants
Observational Model:
Case-Only
Time Perspective:
Prospective
Official Title:
Establishing Automatic Method of Counting and Classify Bone Marrow and Peripheral Blood Cells
Actual Study Start Date :
Aug 28, 2020
Anticipated Primary Completion Date :
Dec 31, 2023
Anticipated Study Completion Date :
Dec 31, 2023

Outcome Measures

Primary Outcome Measures

  1. Evaluate the accuracy of cell counting and classifying between automatic method and manual method through digital microscopic photos of bone marrow smear and peripheral blood smear using deep convolutional neural networks [3 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:
20 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Patients who have suspected or confirmed hematological diseases and receive bone

  • marrow or peripheral blood cell morphological examination in National Taiwan University Cancer Center

  • Patients who are aged more than 20 y/o

Exclusion Criteria:

•Patients who are not willing to sign informed consents

Contacts and Locations

Locations

Site City State Country Postal Code
1 National Taiwan University Tai-Chen Cell Therapy Center Taipei Taiwan

Sponsors and Collaborators

  • National Taiwan University Hospital
  • National Taiwan University Tai-Chen Cell Therapy Center, Biomdcare Corporation

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT04551235
Other Study ID Numbers:
  • 202007086RIPB
First Posted:
Sep 16, 2020
Last Update Posted:
Mar 10, 2022
Last Verified:
Mar 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Mar 10, 2022