Establishing a Tumor Bank in Families With Multiple Lymphoproliferative Malignancies
Study Details
Study Description
Brief Summary
The purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. The databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
-
Patients who participate will be asked to complete detailed family and medical history questionnaires initially, with a follow-up questionnaire every year.
-
Patients will be asked to supply a blood sample and possibly a mouthwash sample, both of which can be done by mail.
-
Patients will be asked to consent to the release of their lymphoma tissue block for the purposes of the study.
-
Patients will be given letters of invitation for their affected relatives to invite them to participate.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Next of Kin of deceased subj by lymphoma Next of Kin of deceased subject by lymphoma |
|
Subject unaffected by lymphoma Subject unaffected by lymphoma |
|
Subject affected by lymphoma Subject affected by lymphoma |
Outcome Measures
Primary Outcome Measures
- Genetic factors that contribute to the development of lymphomas and CLL [Indefinite]
Genetic factors that contribute to the development of lymphomas and CLL
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed.
-
Family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study.
-
Deceased family members may be included in the study. Public records such as death certificates may be used to confirm the history. Consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. The hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. Archived tissue samples may be used for genetic research.
-
Age > 18 years
Exclusion Criteria:
- Subjects without a family history of lymphoma
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02115 |
Sponsors and Collaborators
- Dana-Farber Cancer Institute
Investigators
- Principal Investigator: Jennifer R. Brown, MD, PhD, Dana-Farber Cancer Institute
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 04-165