SURPASSe: Evolution of the SURvival of Patients With SEzary Syndrome (SS) Over the 1998-2020 Period and Its Association With the Early Use of Therapeutic Monoclonal Antibodies
Study Details
Study Description
Brief Summary
Sezary syndrome (SS) is a rare, aggressive and advanced form of cutaneous T lymphoma with a poor prognosis (5-year survival rate varying between 24% and 52%). The treatments are only suspensive with short-term remissions. For the past fifteen years, therapeutic approaches have been based on depleting monoclonal antibodies (anti-CD52, anti-CCR4, anti-KIR3DL2, anti-CD70), or antibody-drug conjugates (anti-CD30). But while the efficacy of mogamulizumab on progression-free survival was reported in the phase III study, no study on a large cohort has compared the current overall survival of patients with Sezary syndrome to that before the era of monoclonal antibodies. In this context, we propose to report a large series of patients with Sézary syndrome in order to compare the current survival of patients with that of the pre-monoclonal antibodies era (1998-2003).
The objective of this study is to assess the evolution of the overall survival of patients with Sezary syndrome since the early use of therapeutic monoclonal antibodies. The underlying hypothesis of this study is that the use of therapeutic monoclonal antibodies has improved the prognosis of these patients. Patients included in this retrospective study are patients with a Sezary syndrome diagnosed between 1998 and 2020.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients with Sezary syndrome Adult patient with Sezary syndrome diagnosed between 1998 and 2020 |
Other: Standard of care
Standard of care for patients with Sezary Syndrome
|
Outcome Measures
Primary Outcome Measures
- Overall Survival [at 5 years]
Secondary Outcome Measures
- Overall survival [at 10 years]
- Overall survival [at 15 years]
- Sezary syndrome specific survival [at 5 years]
- Sezary syndrome specific survival [at 10 years]
- Sezary syndrome specific survival [at 15 years]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Adult patients over 18 years of age
-
Patient with Sezary Syndrome diagnosed between 1998 and 2020
Exclusion Criteria:
-
Patient opposition to research
-
Patient under guardianship or curatorship, unable to express opposition
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hôpital Saint-Louis, Service de Dermatologie | Paris | France | 75010 |
Sponsors and Collaborators
- Assistance Publique - Hôpitaux de Paris
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- APHP211592