Exercise Target Brain Oscillations in Psychosis
Study Details
Study Description
Brief Summary
Previous studies have shown that cardiorespiratory fitness (how well the heart and lungs are able to function during physical activity) is often reduced in people with psychosis. The goal of this research study is to test the hypothesis that aerobic exercise can lead to small changes in brain functioning that can influence visual perception and attention in psychosis. The type of aerobic exercise used in this study is called Sprint Interval Training, or "SIT". Information from this study will help to develop interventions that enhance cognition and maximize the quality of life for persons living with psychosis.
The exercise procedure used is called SIT, which involves training rigorously on a stationary bike for a short period of time followed by a resting period.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Sprint Interval Training (SIT) The 1-session SIT protocol will include "Work" bouts performed at maximal intensity targets. Three "Work" bouts will be performed at 20-second intervals separated by 2 recovery bouts consisting of 2 minutes of low-intensity cycling. The SIT session will employ a standardized warm up and cool down of 3 minutes at a self-selected light intensity, per current guidelines. SIT sessions will take 15 minutes to complete. |
Other: Sprint Interval Training (SIT)
Active arm-- exercise dictated by protocol
|
| Stretching Stretching will include a low-intensity range of motion and stretching exercises with session duration (15 minutes) being matched to SIT. |
Outcome Measures
Primary Outcome Measures
- Change in Individual Alpha Frequency [through study completion, on average 2 weeks]
A prominent neural oscillatory rhythm measured from resting EEG.
- Change in Visual Attention [through study completion, on average 2 weeks]
Computerized tasks that measure speeded sustained attention.
- Change in Visual Perception [through study completion, on average 2 weeks]
Computerized tasks that measure speeded visual perception
Eligibility Criteria
Criteria
Inclusion Criteria:
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Meet diagnostic criteria for schizophrenia or schizoaffective disorder
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Are age 18-64
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Fluent in written and spoken English
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Have an outpatient status of at least 1 month prior to participation
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Has been on a stable dose of psychiatric medication for at least one month prior to participation (titration to a lower dose of psychotropic medications under supervision of a psychiatrist can be allowed at the discretion of the investigators)
Exclusion Criteria:
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Current or possibility of current pregnancy (self-reported)
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Active suicidal ideation at screening or baseline assessments, or previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months, as indicated by the C-SSRS
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WTAR standardized score below 70
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American College of Sports Medicine contraindication to exercise
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Minnesota | Minneapolis | Minnesota | United States | 55455 |
Sponsors and Collaborators
- University of Minnesota
Investigators
- Principal Investigator: Ian Ramsay, University of Minnesota
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PSYCH-2022-30666