Stair Climbing Exercise Versus Traditional Resistance Exercise

Sponsor
KU Leuven (Other)
Overall Status
Recruiting
CT.gov ID
NCT05263115
Collaborator
(none)
50
1
2
5.1
9.9

Study Details

Study Description

Brief Summary

Current evidence suggests resistance exercise as the primary therapeutic strategy to prevent age-related functional decline. The National Strength and Conditioning Association recently stated that a properly designed resistance exercise program should include power exercises performed at higher velocities in concentric movements with moderate intensities. We should be aware that not all older adults are easily motivated to train in unfamiliar gym-based settings with high subscription fees. Therefore, implementation of traditional gym-based resistance exercise at a large scale has been found to be difficult. Interestingly, we have previously shown that the use of high external loads, which implies the need for specific facility memberships, is not necessary to induce neuromuscular gains. This provides strong support for home-based training intervention strategies. Stair climbing or stepping-based exercise constitute a promising avenue to ameliorate the cost-effectiveness and implementation potential of resistance exercise in older adults. Such exercises can induce muscular activation levels similar to high-load resistance exercise and result in similar or even better gains in muscle mass, strength and power compared to slow-speed resistance exercise when properly designed. However, the (neuro)-muscular effects of stair climbing exercise have never been compared to the more optimal power-oriented resistance exercise, which is the primary aim of this study. The secondary aim of this study is to examine if stair climbing exercise also has beneficial effects on cognition.

Condition or Disease Intervention/Treatment Phase
  • Other: Resistance Exercise intervention
  • Other: Functional stair climbing and stepping-based exercise intervention
N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
50 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Prevention
Official Title:
An Individualized Stair Climbing Program Versus Traditional Resistance Exercise: Effects on Strength, Power, Functional Performance and Cognition in Older Adults
Actual Study Start Date :
Feb 11, 2022
Anticipated Primary Completion Date :
Jul 15, 2022
Anticipated Study Completion Date :
Jul 15, 2022

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Resistance exercise

12-week progressive power-oriented resistance exercise program on leg press machine

Other: Resistance Exercise intervention
12-week progressive resistance exercise intervention

Experimental: Functional stair and stepping-based exercise

12-week progressive functional weight-bearing stair and stepping-based exercise program

Other: Functional stair climbing and stepping-based exercise intervention
12-week progressive stair climbing and stepping-based exercise intervention

Outcome Measures

Primary Outcome Measures

  1. F-V profile [Change from baseline in F-v profile at 12 weeks]

    Force-velocity profiling is carried out unilaterally (dominant leg) on the pneumatic leg press device (Leg Press CC, HUR, Kokkola, Finland). The test protocol consists of a maximal isometric test (knee joint angle = 85°, hip angle = 55°; 3 attempts of 3s), followed by explosive concentric leg extensions at gradually increasing loads (unloaded, 15%, 30%, 45%, 60%, 75% of the maximal isometric force, 2-3 attempts per load, and additional single repetitions until one-repetition maximum is reached). Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced adaptations. F0 (maximal force), v0 (maximal velocity), a (the equation's slope), Pmax (maximal power) and the corresponding v and F at Pmax are used for the analyses.

Secondary Outcome Measures

  1. Gait speed [Change from baseline in gait speed at 12 weeks]

    The average speed to walk 10m as fast as possible (in m/s)

  2. 5-repetition sit-to-stand time [Change from baseline in sit-to-stand performance at 12 weeks]

    The time (s) needed to perform 5 sit-to-stand transitions.

  3. 5-repetition sit-to-stand power [Change from baseline in sit-to-stand performance at 12 weeks]

    The power (watt) needed to perform 5 sit-to-stand transitions.

  4. Stair ascent time [Change from baseline in stair climbing performance at 12 weeks.]

    The time (s) needed to ascend a flight of stairs.

  5. Stair ascent power [Change from baseline in stair climbing performance at 12 weeks.]

    The power (watt) needed to ascend a flight of stairs.

  6. Countermovement jump height [Change from baseline in countermovement jump height at 12 weeks.]

    Jump height (cm) in a countermovement jump

  7. MoCA test score [Change from baseline in Montrial Cognitive Assessment test score at 12 weeks.]

    Total score (min 0, max 30, higher scores indicate better performance) on the Montreal Cognitive Assessment test

  8. Digit Span Test score [Change from baseline in Digit Span Test score at 12 weeks.]

    Total score (min 0, max 30, higher scores indicate better performance) on the Digit Span Test

  9. Trail Making Test Time [Change from baseline in Trail Making Test at 12 weeks.]

    Total duration (s) needed to complete the Trail Making Test.

  10. Stroop Test number of words [Change from baseline in Stroop Test at 12 weeks.]

    Total number of words red in 45s in the stroop test.

Eligibility Criteria

Criteria

Ages Eligible for Study:
65 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
Exclusion Criteria:
  • Unstable cardiovascular disease

  • Neurological disorders

  • Cognitive malfunctioning (MoCA < 24)

  • Low level of physical function (SPPB < 7)

  • Acute infections/fever

  • Severe musculoskeletal problems

  • Systematic engagement in (resistance) exercise in the 12 months prior to participation

Contacts and Locations

Locations

Site City State Country Postal Code
1 Department of Movement Sciences Leuven Belgium 3001

Sponsors and Collaborators

  • KU Leuven

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Evelien Van Roie, Principal Investigator, KU Leuven
ClinicalTrials.gov Identifier:
NCT05263115
Other Study ID Numbers:
  • S66174
First Posted:
Mar 2, 2022
Last Update Posted:
Mar 2, 2022
Last Verified:
Feb 1, 2022
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No

Study Results

No Results Posted as of Mar 2, 2022