Myopic Optic Neuropathy in Chinese High Myopia Population
Study Details
Study Description
Brief Summary
This study intends to establish a registry cohort to enroll patients with high myopia to study the natural course of myopic optic neuropathy in Chinese adult population.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Global prevalence of high myopia brings about markedly increasing of blinding complications as myopic optic neuropathy (MON) and glaucoma. It was estimated that there were 163 million people who have high myopia in 2000, and the population with high myopia would increase to almost one billion (9.8% of the world population) worldwide by 2050.
Glaucoma is the leading cause of irreversible blindness worldwide while it is difficult to distinguish glaucoma among MON in high myopia eyes. However, there lack longitudinal study to illustrate the natural course interpreting the distribution and natural history of MON.
In view of the above problems, this is a longitudinal registry cohort study to observe the long-term changes of structural and functional parameters of MON in high myopia, and to investigate the natural course and associted risk factors that influence the progression in a Chinese adult population.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
high myopia Population who have high myopia. |
Outcome Measures
Primary Outcome Measures
- Progression of glaucoma within 36 months [3 years]
Structural and functional changes of glaucoma using visual field, stereoscopic fundus photography.
Secondary Outcome Measures
- Progression of myopia and other structural changes of retina and choroid. [3 years]
Structural and functional changes of myopia based on axial length and refractive error.
Eligibility Criteria
Criteria
Inclusion Criteria
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Age ≥18 years
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Equivalent spherical ≤-6D or axial length ≥26.5mm
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Best corrected visual acuity ≥ 6/12
Exclusion Criteria
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Unwilling or unable to give consent, or unable to return for scheduled protocol visits.
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Glaucoma secondary to penetrating keratoplasty, trauma, steroids, retinal disease/surgery, or neovascular disease.
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Obvious corneal and iris lesions, or severe cataracts interfering with fundus examinations, VF test or monophthalmia.
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Need for ocular surgery/laser or anticipated need for cataract surgery during the study period.
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Other serious systemic diseasesf (i.e. hypertension, heart disease, diabetes, or rheumatic immune system diseases);
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Pregnant or nursing women
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Zhongshan Ophthalmic Center | Guangzhou | Guangdong | China | 510000 |
Sponsors and Collaborators
- Sun Yat-sen University
Investigators
- Principal Investigator: Xiulan Zhang, MD, PhD, Zhongshan Ophthalmic Center, Sun Yat-sen University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2019KYPJ079