EyeConic: Qualification for Cone-Optogenetics
Study Details
Study Description
Brief Summary
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Patients -Availability of macular optical coherence tomography (OCT) |
Diagnostic Test: OCT
Macular optical coherence tomography (OCT)
|
Controls -Availability of macular optical coherence tomography (OCT) |
Diagnostic Test: OCT
Macular optical coherence tomography (OCT)
|
Outcome Measures
Primary Outcome Measures
- OCT - Central retinal volume [Baseline (about 10 minutes)]
Number of participants with preserved central retinal volume
Eligibility Criteria
Criteria
Inclusion Criteria (patients):
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Diagnosis of generalized IRD
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Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye
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Availability of macular optical coherence tomography (OCT)
Inclusion Criteria (controls):
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Normal ophthalmic findings
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Availability of macular optical coherence tomography (OCT)
Exclusion Criteria (all):
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Other eye diseases with a significant effect on vision or retinal structure
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Extraocular disease affecting retinal structure such as neurodegenerative diseases
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University of California San Francisco, Department of Ophthalmology | San Francisco | California | United States | 94158 |
2 | Bascom Palmer Eye Institute | Miami | Florida | United States | 33136 |
3 | University of Pittsburgh, Department of Ophthalmology | Pittsburgh | Pennsylvania | United States | 15213 |
4 | Beijing Institute of Ophthalmology | Beijing | China | ||
5 | Universitätsklinikum Tübingen Augenklinik | Tübingen | Germany | ||
6 | Semmelweis University, Department of Ophthalmology | Budapest | Hungary | ||
7 | Oculista Ospedale Parma | Parma | Italy | ||
8 | University Hospital Basel, Eye Clinic | Basel | Switzerland | 4031 | |
9 | Moorfields Eye Hospital | London | United Kingdom |
Sponsors and Collaborators
- University Hospital, Basel, Switzerland
- Institute of Molecular and Clinical Ophthalmology Basel, Switzerland
Investigators
- Principal Investigator: Hendrik PN Scholl, MD, University Hospital Basel/Institute of Molecular and Clinical Ophthalmology Basel, Switzerland
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IOB_EyeConic_2021