Facial Demodicosis and Ocular Demodicosis
Study Details
Study Description
Brief Summary
To understand the association between facial demodicosis and ocular demodicosis, we plan to enroll patients with facial demodicosis, ocular demodicosis, or both, in order to analyze their clinical presentations, the density of Demodex infestation over facial skin and eyelashes, and possible risk factors of the two diagnoses.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Although facial demodicosis and ocular demodicosis are described in a variety of clinical presentations, the association between the two diagnoses is not clearly identified.
Clinically, we plan to enroll 120 patients with facial demodicosis, ocular demodicosis. We will obtain their basic information, medical history, medication, and lifestyle. We will evaluate their clinical features. We will also perform quantitative tests including direct microscopic examination and cilia epilation test:
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Direct microscopic examination: On glabella and bilateral cheeks, follicular contents in the 1-cm × 1-cm area will be squeezed out. The contents are transferred onto a glass slide, covered with mineral oil and a cover slide, and examined under the microscope.
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Epilation: Four (4) non-adjacent cilia will be pulled from each upper eyelid and examined under the microscope. The total Demodex counts are recorded.
We will analyze the clinical presentations, the density of Demodex infestation, and possible risk factors of the two diagnoses.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Facial Demodicosis Clinical presentation of facial skin matches any of the followings: Pityriasis folliculorum. Papulopustular lesion. Rosacea. Demodex infestation detected by direct microscopic examination ≥ 5 mites/cm2. |
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Ocular Demodicosis Clinical presentation of ocular region matches any of the followings: Chronic blepharitis. Eyelash abnormalities: trichiasis, distichiasis, madarosis. Meibomian gland dysfunction. Recurrent chalazion. Ocular rosacea. Demodex infestation detected by cilia epilation test ≥ 1 mite/eyelid. |
Outcome Measures
Primary Outcome Measures
- Quantitative tests of facial and ocular demodicosis [On initial evaluation]
Association between the results of direct microscopic examination and cilia epilation test
Secondary Outcome Measures
- Clinical features and quantitative tests of facial demodicosis [On initial evaluation]
Association between the clinical features and the result of direct microscopic examination
- Clinical features and quantitative tests of ocular demodicosis [On initial evaluation]
Association between the clinical features and the result of cilia epilation
Eligibility Criteria
Criteria
Inclusion Criteria:
Patient with a diagnosis of facial demodicosis or ocular demodicosis.
A. Facial demodicosis defined as both 1 and 2:
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Clinical presentation of facial skin matches any of the followings:
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Pityriasis folliculorum.
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Papulopustular lesion.
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Rosacea.
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Demodex infestation detected by direct microscopic examination ≥ 5 mites/cm2.
B. Ocular demodicosis defined as both 3 and 4:
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Clinical presentation of ocular region matches any of the followings:
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Chronic blepharitis.
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Eyelash abnormalities: trichiasis, distichiasis, madarosis.
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Meibomian gland dysfunction.
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Recurrent chalazion.
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Ocular rosacea.
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Demodex infestation detected by cilia epilation test ≥ 1 mite/eyelid.
Exclusion Criteria:
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Usage of oral Ivermectin, topical Ivermectin or topical tea tree oil in the past 1 month.
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Patient who cannot tolerate direct microscopic examination or cilia epilation test.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | National Taiwan University Hospital | Taipei | Taiwan | 100229 |
Sponsors and Collaborators
- National Taiwan University Hospital
Investigators
- Principal Investigator: Chia-Yu Chu, M.D., Ph.D., National Taiwan University Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Aşkin U, Seçkin D. Comparison of the two techniques for measurement of the density of Demodex folliculorum: standardized skin surface biopsy and direct microscopic examination. Br J Dermatol. 2010 May;162(5):1124-6. doi: 10.1111/j.1365-2133.2010.09645.x. Epub 2010 Feb 25.
- Chen W, Plewig G. Human demodicosis: revisit and a proposed classification. Br J Dermatol. 2014 Jun;170(6):1219-25. doi: 10.1111/bjd.12850. Review.
- Gao YY, Di Pascuale MA, Li W, Liu DT, Baradaran-Rafii A, Elizondo A, Kawakita T, Raju VK, Tseng SC. High prevalence of Demodex in eyelashes with cylindrical dandruff. Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3089-94.
- 201912024RIND