Treatment and Fate in Fistulizing Crohn's Disease in a Pediatric Population
Study Details
Study Description
Brief Summary
Crohn's disease is a inflammatory bowel disease evolving towards the destruction of the intestinal wall resulting in stenosing or perforating complications (fistulas, abscesses).
The treatment of perforating Crohn's disease is not codified.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The old dogmas leading to surgery after failure of medical treatment have recently been overturned, particularly since the advent of anti-TNFs.
Biotherapies now have a central place, including for complicated forms. Previous studies have already looked at the usefulness of anti-TNFs in stenosing forms, or concerning ano-perineal lesions, but what about digestive fistulas.
Indeed, data are scarce, especially in paediatrics.
Study Design
Outcome Measures
Primary Outcome Measures
- No fistula [12 month]
Complete remission = clinical remission and biological remission and iconographic remission: clinical remission (asymptomatic at 12 months from inclusion). biological remission (normalization of biological parameters 12 months after inclusion). iconographic remission (no active lesion, and in particular no visualized fistula)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Minor patients (aged 3 to 18).
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Diagnosed with Crohn's disease.
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fistulizing crohn's disease
Exclusion Criteria:
- perianal crohn disease
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022PI067