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Tazemetostat in Treating Patients With Recurrent Ovarian or Endometrial Cancer

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Suspended
CT.gov ID
NCT03348631
Collaborator
NRG Oncology (Other)
86
Enrollment
585
Locations
1
Arm
70.1
Anticipated Duration (Months)
0.1
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase II trial studies how well tazemetostat works in treating patients with ovarian or endometrial cancer that has come back (recurrent). Chemotherapy drugs, such as tazemetostat, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

Condition or Disease Intervention/Treatment Phase
Phase 2

Detailed Description

PRIMARY OBJECTIVE:

  1. To assess the clinical activity (overall response rate) of tazemetostat in patients with recurrent or persistent endometrioid or clear cell ovarian carcinoma, and patients with recurrent or persistent endometrioid endometrial adenocarcinoma.

  2. To assess the clinical activity (response frequency) of tazemetostat in patients with recurrent or persistent clear cell ovarian carcinoma with an ARID1A mutation.

SECONDARY OBJECTIVES:

  1. To examine the nature and degree of toxicity in patients with this regimen. II. To examine the progression free survival and overall survival for this patient population receiving tazemetostat.

  2. To examine the 6 month clinical benefit rate in patients treated with this regimen. (20-OCT-2021) IV. To evaluate BAF250a expression in patient samples as an indicator of ARID1A mutation status and correlation with the clinical response to study drug. Note: this only applies to patients enrolled prior to the 20-OCT-2021 version date. (20-OCT-2021)

EXPLORATORY OBJECTIVES:
  1. Whether or not the patient has an ARID1A mutation. (08/13/2019) Note: this only applies to patients enrolled prior to the 20-OCT-2021 version date. (20-OCT-2021) (Translational Research Integrated Objective) II. To examine the correlation between ARID1A mutation and BAF250a expression and to identify potential mutations predictive of response in patients with preserved BAF250a expression. Note: this only applies to patients enrolled prior to the 20-OCT-2021 version date. (20-OCT-2021)
OUTLINE:

Patients receive tazemetostat orally (PO) twice daily (BID) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
86 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Phase II Study of Tazemetostat (EPZ-6438) (IND # 138671) in Recurrent or Persistent Endometrioid or Clear Cell Carcinoma of the Ovary, and Recurrent or Persistent Endometrioid Endometrial Adenocarcinoma
Actual Study Start Date :
Mar 29, 2019
Anticipated Primary Completion Date :
Jan 31, 2025
Anticipated Study Completion Date :
Jan 31, 2025

Arms and Interventions

Arm Intervention/Treatment
Experimental: Treatment (tazemetostat)

Patients receive tazemetostat PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Drug: Tazemetostat
Given PO
Other Names:
  • E7438
  • EPZ-6438
  • EPZ6438

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Tumor response [Up to 6 months]

      Will be defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1.

    Secondary Outcome Measures

    1. Tumor response in patients with ARID1A mutations using tumor response [Up to 6 months]

      Will be defined by RECIST v 1.1.

    2. 6-month progression free survival (clinical benefit rate) [Up to 6 months]

    3. Incidence of adverse events [Up to 5 years]

      Will be assessed according to grade of toxicity by organ or organ system.

    4. Progression-free survival [From study entry to time of progression or death, whichever occurs first, assessed up to 5 years]

      Will be characterized by quartiles and the median of the distribution with confidence intervals. Kaplan-Meier plots will show an estimate of the survival function for these populations.

    5. Overall survival [From study entry to time of death or the date of last contact, assessed up to 5 years]

      Will be characterized by quartiles and the median of the distribution with confidence intervals. Kaplan-Meier plots will show an estimate of the survival function for these populations.

    Other Outcome Measures

    1. ARID1A mutational status [Up to 6 months]

      Associations between BAF250a and ARID1A mutations may be examined with contingency table analysis (e.g. potentially including Chi-square analyses or Spearman's correlation).

    2. BAF250a expression [Up to 6 months]

      Will be assessed by immunohistochemistry. Associations between BAF250a and ARID1A mutations may be examined with contingency table analysis (e.g. potentially including Chi-square analyses or Spearman's correlation).

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Pathologically (histologically or cytologically) proven diagnosis of recurrent or persistent ovarian endometrioid or clear cell carcinoma, OR recurrent or persistent endometrioid endometrial adenocarcinoma; patients with recurrent endometrial cancer must have mismatch repair (MMR) immunohistochemistry completed; if they are found to be mismatch repair deficient, they should be offered treatment with immune checkpoint inhibition before consideration for treatment on trial; primary ovarian tumors must be at least 50% endometrioid or clear cell morphology, or have histologically documented recurrence with at least 50% endometrioid or clear cell morphology; institutional pathology reports must be provided indicating at least 50% endometrioid or clear cell morphology for ovarian tumors (primary or recurrent lesions)

    • Only patients with recurrent or persistent ovarian clear cell carcinoma (OCCC) with ARID1A pathologic variant or likely pathologic variant mutations per next generation sequencing (NGS) are eligible for entry (20-OCT-2021)

    • Institutional pathology reports must be provided indicating at least 50% clear cell morphology for ovarian tumors (primary or recurrent lesions) and NGS report must be available for step 1 registration (20-OCT-2021)

    • All other eligibility criteria and ineligibility criteria must be met (20-OCT-2021)

    • All patients must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded); each lesion must be >= 10 mm when measured by computed tomography (CT), magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or >= 20 mm when measured by chest x-ray; lymph nodes must be >= 15 mm in short axis when measured by CT or MRI

    • Patients must have had at least one, but no more than 3, prior cytotoxic regimens for management of primary disease; unlimited prior hormonal therapy, targeted therapy (including immunotherapy) or antiangiogenic therapy will be permitted

    • Patients must have completed prior therapy:

    • Chemotherapy: cytotoxic

    • At least 28 days since last dose of chemotherapy prior to step 2 registration.

    • Chemotherapy: nitrosoureas

    • At least 6 weeks since last dose of chemotherapy prior to step 2 registration.

    • Chemotherapy: non-cytotoxic (e.g. small molecule inhibitor)

    • At least 28 days since last dose of chemotherapy prior to step 2 registration.

    • Monoclonal antibody(ies)

    • At least 28 days since last dose of monoclonal antibody prior to step 2 registration.

    • Immunotherapy

    • At least 28 days since last dose of immunotherapy prior to step 2 registration.

    • Radiotherapy (RT)

    • At least 14 days from last local site RT prior to step 2 registration.

    • At least 21 days from stereotactic radiosurgery prior to step 2 registration.

    • At least 12 weeks from craniospinal, >= 50% radiation of pelvis or total body irradiation prior to step 2 registration.

    • Patients with central nervous system (CNS) disease should demonstrate evidence of stabilization after the 28-day time point after definitive treatment.

    • Full recovery of radiation related side effects prior to step 2 registration.

    • All subjects must have evidence of measurable disease outside of the radiation field at the time of step 2 registration

    • Appropriate stage for study entry based on the following diagnostic workup:

    • History/physical examination within 14 days prior to step 2 registration

    • Imaging of the chest, abdomen and pelvis within 28 days prior to step 2 registration

    • Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2 within 14 days prior to step 2 registration

    • Platelets >= 100,000/mcl (within 14 days prior to step 2 registration)

    • Absolute neutrophil count (ANC) >= 1,500/mcl (within 14 days prior to step 2 registration)

    • Hemoglobin (Hgb) >= 8 g/dL (within 14 days prior to step 2 registration)

    • Differential with no clinically significant morphologic abnormalities on complete blood count (CBC) testing; manual differential is encouraged, if clinically indicated, and in cases where an automated differential is abnormal (within 14 days prior to step 2 registration)

    • Creatinine =< 1.5 x institutional/laboratory upper limit of normal (ULN) (within 14 days prior to step 2 registration)

    • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (within 14 days prior to step 2 registration)

    • Total serum bilirubin level =< 1.5 x ULN; direct bilirubin =< ULN for subjects with total bilirubin > 1.5 x ULN (patients with isolated indirect bilirubin elevations and a history of Gilbert's syndrome are eligible) (within 14 days prior to step 2 registration)

    • Patients must be able to swallow and retain oral medications and not have gastrointestinal illnesses that would preclude absorption of tazemetostat as judged by the treating physician (20-OCT-2021)

    • Women of childbearing potential must be willing and able to use adequate contraception (hormonal and barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 6 months after the last dose of study agent; should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should inform her treating physician immediately; theoretically, CYP3A induction with tazemetostat use may result in the loss of efficacy in hormonal contraceptives, thus a barrier method of contraception must be used in addition to hormonal contraceptives due to the potential drug-drug interaction with tazemetostat

    • The patient or a legally authorized representative must provide study-specific informed consent and authorization permitting release of personal health information prior to study entry

    • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

    Exclusion Criteria:

    • Prior treatment with an investigational EZH2 inhibitor

    • A prior history of myeloid malignancies, including myelodysplastic syndrome (MDS)

    • Abnormalities known to be associated with MDS (e.g. del 5q, chr 7 abn) and myeloproliferative neoplasms (MPN) (e.g. JAK2 V617F) observed in cytogenetic testing and deoxyribonucleic acid (DNA) sequencing

    • A prior history of T-cell lymphoblastic lymphoma (T-LBL)/T-cell acute lymphoblastic leukemia (T-ALL)

    • Patients who have had therapeutic paracentesis or thoracentesis within 8 weeks prior to step 2 registration

    • Patients with clinical or radiographic evidence of bowel obstruction

    • Severe, active co-morbidity per the treating investigator's discretion

    • Pregnant or lactating patients

    • Known human immunodeficiency virus (HIV) positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with tazemetostat; in addition, treatments involved in this protocol may be immunosuppressive, increasing the risk of lethal infections in this patient population

    • Treatment with strong and moderate inhibitors or inducers of CYP3A within 14 days of step 2 registration and during the study treatment

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 CTCA at Western Regional Medical Center Goodyear Arizona United States 85338
    10 Kingman Regional Medical Center Kingman Arizona United States 86401
    11 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    12 Mayo Clinic Hospital in Arizona Phoenix Arizona United States 85054
    13 Mayo Clinic in Arizona Scottsdale Arizona United States 85259
    14 University of Arizona Cancer Center-Orange Grove Campus Tucson Arizona United States 85704
    15 Banner University Medical Center - Tucson Tucson Arizona United States 85719
    16 University of Arizona Cancer Center-North Campus Tucson Arizona United States 85719
    17 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    18 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    19 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    20 PCR Oncology Arroyo Grande California United States 93420
    21 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    22 UC San Diego Moores Cancer Center La Jolla California United States 92093
    23 Providence Queen of The Valley Napa California United States 94558
    24 Saint Joseph Hospital - Orange Orange California United States 92868
    25 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    26 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    27 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    28 Providence Medical Foundation - Santa Rosa Santa Rosa California United States 95403
    29 Providence Santa Rosa Memorial Hospital Santa Rosa California United States 95405
    30 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    31 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    32 UCHealth Memorial Hospital Central Colorado Springs Colorado United States 80909
    33 Memorial Hospital North Colorado Springs Colorado United States 80920
    34 Saint Francis Cancer Center Colorado Springs Colorado United States 80923
    35 Porter Adventist Hospital Denver Colorado United States 80210
    36 Mercy Medical Center Durango Colorado United States 81301
    37 Southwest Oncology PC Durango Colorado United States 81301
    38 Poudre Valley Hospital Fort Collins Colorado United States 80524
    39 Cancer Care and Hematology-Fort Collins Fort Collins Colorado United States 80528
    40 UCHealth Greeley Hospital Greeley Colorado United States 80631
    41 Saint Anthony Hospital Lakewood Colorado United States 80228
    42 Littleton Adventist Hospital Littleton Colorado United States 80122
    43 Longmont United Hospital Longmont Colorado United States 80501
    44 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    45 Medical Center of the Rockies Loveland Colorado United States 80538
    46 Parker Adventist Hospital Parker Colorado United States 80138
    47 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    48 Smilow Cancer Hospital-Derby Care Center Derby Connecticut United States 06418
    49 Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut United States 06824
    50 Smilow Cancer Hospital Care Center - Guiford Guilford Connecticut United States 06437
    51 Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut United States 06105
    52 Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut United States 06510
    53 Yale University New Haven Connecticut United States 06520
    54 Smilow Cancer Hospital-Orange Care Center Orange Connecticut United States 06477
    55 Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut United States 06790
    56 Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut United States 06611
    57 Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut United States 06708
    58 Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut United States 06385
    59 Florida Cancer Specialists - Bradenton Bradenton Florida United States 34209
    60 University of Florida Health Science Center - Gainesville Gainesville Florida United States 32610
    61 Florida Cancer Specialists - Sarasota Sarasota Florida United States 34232
    62 Florida Cancer Specialists - Sarasota Downtown Sarasota Florida United States 34236
    63 Sarasota Memorial Hospital Sarasota Florida United States 34239
    64 Florida Cancer Specialists - Venice Island Venice Florida United States 34285
    65 Florida Cancer Specialists - Venice Healthpark Venice Florida United States 34292
    66 Northside Hospital Atlanta Georgia United States 30342
    67 Augusta University Medical Center Augusta Georgia United States 30912
    68 CTCA at Southeastern Regional Medical Center Newnan Georgia United States 30265
    69 Memorial Health University Medical Center Savannah Georgia United States 31404
    70 Summit Cancer Care-Memorial Savannah Georgia United States 31404
    71 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    72 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    73 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    74 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    75 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    76 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    77 Queen's Medical Center Honolulu Hawaii United States 96813
    78 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    79 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    80 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    81 Kuakini Medical Center Honolulu Hawaii United States 96817
    82 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    83 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    84 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    85 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    86 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    87 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    88 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    89 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    90 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    91 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    92 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    93 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    94 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    95 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    96 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    97 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    98 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    99 Saint Anthony's Health Alton Illinois United States 62002
    100 Rush - Copley Medical Center Aurora Illinois United States 60504
    101 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    102 Illinois CancerCare-Canton Canton Illinois United States 61520
    103 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    104 SIH Cancer Institute Carterville Illinois United States 62918
    105 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    106 Centralia Oncology Clinic Centralia Illinois United States 62801
    107 Northwestern University Chicago Illinois United States 60611
    108 Rush University Medical Center Chicago Illinois United States 60612
    109 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    110 Advocate Illinois Masonic Medical Center Chicago Illinois United States 60657
    111 AMG Crystal Lake - Oncology Crystal Lake Illinois United States 60014
    112 Carle on Vermilion Danville Illinois United States 61832
    113 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    114 Decatur Memorial Hospital Decatur Illinois United States 62526
    115 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    116 Advocate Good Samaritan Hospital Downers Grove Illinois United States 60515
    117 Carle Physician Group-Effingham Effingham Illinois United States 62401
    118 Crossroads Cancer Center Effingham Illinois United States 62401
    119 Advocate Sherman Hospital Elgin Illinois United States 60123
    120 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    121 NorthShore University HealthSystem-Evanston Hospital Evanston Illinois United States 60201
    122 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    123 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    124 NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois United States 60026
    125 Advocate South Suburban Hospital Hazel Crest Illinois United States 60429
    126 NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois United States 60035
    127 Sudarshan K Sharma MD Limited-Gynecologic Oncology Hinsdale Illinois United States 60521
    128 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    129 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    130 AMG Libertyville - Oncology Libertyville Illinois United States 60048
    131 Condell Memorial Hospital Libertyville Illinois United States 60048
    132 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    133 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    134 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    135 UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois United States 60451
    136 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    137 Advocate Christ Medical Center Oak Lawn Illinois United States 60453-2699
    138 University of Chicago Medicine-Orland Park Orland Park Illinois United States 60462
    139 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    140 Advocate Lutheran General Hospital Park Ridge Illinois United States 60068
    141 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    142 OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois United States 61554
    143 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    144 OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois United States 61615
    145 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    146 OSF Saint Francis Medical Center Peoria Illinois United States 61637
    147 Illinois CancerCare-Peru Peru Illinois United States 61354
    148 Valley Radiation Oncology Peru Illinois United States 61354
    149 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    150 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    151 Springfield Clinic Springfield Illinois United States 62702
    152 Memorial Medical Center Springfield Illinois United States 62781
    153 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    154 Carle Cancer Center Urbana Illinois United States 61801
    155 The Carle Foundation Hospital Urbana Illinois United States 61801
    156 Illinois CancerCare - Washington Washington Illinois United States 61571
    157 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    158 Midwestern Regional Medical Center Zion Illinois United States 60099
    159 Parkview Regional Medical Center Fort Wayne Indiana United States 46845
    160 Saint Vincent Hospital and Health Care Center Indianapolis Indiana United States 46260
    161 Reid Health Richmond Indiana United States 47374
    162 Mary Greeley Medical Center Ames Iowa United States 50010
    163 McFarland Clinic PC - Ames Ames Iowa United States 50010
    164 McFarland Clinic PC-Boone Boone Iowa United States 50036
    165 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    166 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    167 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    168 Greater Regional Medical Center Creston Iowa United States 50801
    169 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    170 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    171 Broadlawns Medical Center Des Moines Iowa United States 50314
    172 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    173 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    174 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    175 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    176 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    177 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    178 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    179 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    180 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    181 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    182 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    183 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    184 Saint Luke's South Hospital Overland Park Kansas United States 66213
    185 Associates In Womens Health Wichita Kansas United States 67208
    186 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    187 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    188 Saint Elizabeth Healthcare Edgewood Edgewood Kentucky United States 41017
    189 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    190 Saint Joseph Hospital East Lexington Kentucky United States 40509
    191 Saint Joseph London London Kentucky United States 40741
    192 Jewish Hospital Louisville Kentucky United States 40202
    193 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    194 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    195 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    196 Baton Rouge General Medical Center Baton Rouge Louisiana United States 70806
    197 Hematology/Oncology Clinic PLLC Baton Rouge Louisiana United States 70809
    198 Tulane University Health Sciences Center New Orleans Louisiana United States 70112
    199 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    200 Eastern Maine Medical Center Bangor Maine United States 04401
    201 Lafayette Family Cancer Center-EMMC Brewer Maine United States 04412
    202 Mercy Medical Center Springfield Massachusetts United States 01104
    203 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    204 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    205 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    206 Saint Joseph Mercy Canton Canton Michigan United States 48188
    207 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    208 Caro Cancer Center Caro Michigan United States 48723
    209 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    210 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    211 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    212 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    213 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    214 Ascension Saint John Hospital Detroit Michigan United States 48236
    215 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    216 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    217 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    218 Genesee Hematology Oncology PC Flint Michigan United States 48503
    219 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    220 Hurley Medical Center Flint Michigan United States 48503
    221 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    222 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    223 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    224 Sparrow Hospital Lansing Michigan United States 48912
    225 Hope Cancer Clinic Livonia Michigan United States 48154
    226 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    227 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    228 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    229 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    230 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    231 Hope Cancer Center Pontiac Michigan United States 48341
    232 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    233 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    234 Huron Medical Center PC Port Huron Michigan United States 48060
    235 Lake Huron Medical Center Port Huron Michigan United States 48060
    236 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    237 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    238 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    239 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    240 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    241 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    242 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    243 Macomb Hematology Oncology PC Warren Michigan United States 48093
    244 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    245 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    246 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    247 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    248 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    249 Riverwood Healthcare Center Aitkin Minnesota United States 56431
    250 Essentia Health - Baxter Clinic Baxter Minnesota United States 56425
    251 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    252 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    253 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    254 Cambridge Medical Center Cambridge Minnesota United States 55008
    255 Mercy Hospital Coon Rapids Minnesota United States 55433
    256 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    257 Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota United States 56501
    258 Essentia Health Cancer Center Duluth Minnesota United States 55805
    259 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    260 Miller-Dwan Hospital Duluth Minnesota United States 55805
    261 Fairview Southdale Hospital Edina Minnesota United States 55435
    262 Essentia Health - Ely Clinic Ely Minnesota United States 55731
    263 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    264 Essentia Health - Fosston Fosston Minnesota United States 56542
    265 Unity Hospital Fridley Minnesota United States 55432
    266 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    267 Essentia Health - International Falls Clinic International Falls Minnesota United States 56649
    268 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    269 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    270 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    271 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    272 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    273 Health Partners Inc Minneapolis Minnesota United States 55454
    274 Monticello Cancer Center Monticello Minnesota United States 55362
    275 Essentia Health - Moose Lake Clinic Moose Lake Minnesota United States 55767
    276 New Ulm Medical Center New Ulm Minnesota United States 56073
    277 Essentia Health - Park Rapids Park Rapids Minnesota United States 56470
    278 Fairview Northland Medical Center Princeton Minnesota United States 55371
    279 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    280 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    281 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    282 Regions Hospital Saint Paul Minnesota United States 55101
    283 United Hospital Saint Paul Minnesota United States 55102
    284 Essentia Health Sandstone Sandstone Minnesota United States 55072
    285 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    286 Lakeview Hospital Stillwater Minnesota United States 55082
    287 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    288 Ridgeview Medical Center Waconia Minnesota United States 55387
    289 Rice Memorial Hospital Willmar Minnesota United States 56201
    290 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    291 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    292 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    293 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    294 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    295 Cox Cancer Center Branson Branson Missouri United States 65616
    296 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    297 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    298 Parkland Health Center - Farmington Farmington Missouri United States 63640
    299 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    300 Freeman Health System Joplin Missouri United States 64804
    301 Mercy Hospital Joplin Joplin Missouri United States 64804
    302 Saint Luke's Hospital of Kansas City Kansas City Missouri United States 64111
    303 Saint Luke's East - Lee's Summit Lee's Summit Missouri United States 64086
    304 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    305 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    306 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    307 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    308 Washington University School of Medicine Saint Louis Missouri United States 63110
    309 Mercy Hospital South Saint Louis Missouri United States 63128
    310 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    311 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    312 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    313 Mercy Hospital Springfield Springfield Missouri United States 65804
    314 CoxHealth South Hospital Springfield Missouri United States 65807
    315 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    316 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    317 Mercy Hospital Washington Washington Missouri United States 63090
    318 Community Hospital of Anaconda Anaconda Montana United States 59711
    319 Billings Clinic Cancer Center Billings Montana United States 59101
    320 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    321 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    322 Great Falls Clinic Great Falls Montana United States 59405
    323 Saint Peter's Community Hospital Helena Montana United States 59601
    324 Kalispell Regional Medical Center Kalispell Montana United States 59901
    325 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    326 Community Medical Hospital Missoula Montana United States 59804
    327 CHI Health Saint Francis Grand Island Nebraska United States 68803
    328 CHI Health Good Samaritan Kearney Nebraska United States 68847
    329 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    330 Nebraska Cancer Specialists/Oncology Hematology West PC - MECC Omaha Nebraska United States 68114
    331 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    332 Oncology Associates PC Omaha Nebraska United States 68114
    333 Nebraska Medicine-Village Pointe Omaha Nebraska United States 68118
    334 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    335 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    336 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    337 Creighton University Medical Center Omaha Nebraska United States 68131
    338 University of Nebraska Medical Center Omaha Nebraska United States 68198
    339 Midlands Community Hospital Papillion Nebraska United States 68046
    340 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    341 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    342 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    343 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    344 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    345 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    346 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    347 GenesisCare USA - Henderson Henderson Nevada United States 89074
    348 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    349 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    350 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    351 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    352 Desert West Surgery Las Vegas Nevada United States 89102
    353 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    354 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    355 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    356 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    357 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    358 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    359 Women's Cancer Center of Nevada Las Vegas Nevada United States 89106
    360 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    361 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    362 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    363 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    364 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    365 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    366 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    367 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    368 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    369 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    370 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    371 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    372 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    373 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    374 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    375 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    376 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    377 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    378 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    379 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    380 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    381 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    382 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    383 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    384 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    385 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    386 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    387 University Cancer Center Las Vegas Nevada United States 89169
    388 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    389 Renown Regional Medical Center Reno Nevada United States 89502
    390 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    391 Radiation Oncology Associates Reno Nevada United States 89509
    392 Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey United States 07920
    393 Memorial Sloan Kettering Monmouth Middletown New Jersey United States 07748
    394 Memorial Sloan Kettering Bergen Montvale New Jersey United States 07645
    395 Memorial Sloan Kettering Commack Commack New York United States 11725
    396 Memorial Sloan Kettering Westchester Harrison New York United States 10604
    397 Memorial Sloan Kettering Cancer Center New York New York United States 10065
    398 University of Rochester Rochester New York United States 14642
    399 Memorial Sloan Kettering Nassau Uniondale New York United States 11553
    400 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    401 Essentia Health - Jamestown Clinic Jamestown North Dakota United States 58401
    402 Aultman Alliance Community Hospital Alliance Ohio United States 44601
    403 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
    404 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    405 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    406 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    407 Aultman Health Foundation Canton Ohio United States 44710
    408 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    409 Miami Valley Hospital South Centerville Ohio United States 45459
    410 Geauga Hospital Chardon Ohio United States 44024
    411 Adena Regional Medical Center Chillicothe Ohio United States 45601
    412 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    413 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    414 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    415 Bethesda North Hospital Cincinnati Ohio United States 45242
    416 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    417 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    418 Case Western Reserve University Cleveland Ohio United States 44106
    419 Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio United States 44111
    420 Cleveland Clinic Foundation Cleveland Ohio United States 44195
    421 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    422 Mount Carmel East Hospital Columbus Ohio United States 43213
    423 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    424 Riverside Methodist Hospital Columbus Ohio United States 43214
    425 Grant Medical Center Columbus Ohio United States 43215
    426 The Mark H Zangmeister Center Columbus Ohio United States 43219
    427 Mount Carmel Health Center West Columbus Ohio United States 43222
    428 Doctors Hospital Columbus Ohio United States 43228
    429 Grandview Hospital Dayton Ohio United States 45405
    430 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    431 Miami Valley Hospital Dayton Ohio United States 45409
    432 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    433 Miami Valley Hospital North Dayton Ohio United States 45415
    434 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    435 Grady Memorial Hospital Delaware Ohio United States 43015
    436 Columbus Oncology and Hematology Associates Dublin Ohio United States 43016
    437 Dublin Methodist Hospital Dublin Ohio United States 43016
    438 Armes Family Cancer Center Findlay Ohio United States 45840
    439 Blanchard Valley Hospital Findlay Ohio United States 45840
    440 Orion Cancer Care Findlay Ohio United States 45840
    441 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    442 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    443 Central Ohio Breast and Endocrine Surgery Gahanna Ohio United States 43230
    444 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    445 Wayne Hospital Greenville Ohio United States 45331
    446 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    447 Greater Dayton Cancer Center Kettering Ohio United States 45409
    448 First Dayton Cancer Care Kettering Ohio United States 45420
    449 Kettering Medical Center Kettering Ohio United States 45429
    450 Fairfield Medical Center Lancaster Ohio United States 43130
    451 Saint Rita's Medical Center Lima Ohio United States 45801
    452 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    453 Marietta Memorial Hospital Marietta Ohio United States 45750
    454 OhioHealth Marion General Hospital Marion Ohio United States 43302
    455 Hillcrest Hospital Cancer Center Mayfield Heights Ohio United States 44124
    456 Knox Community Hospital Mount Vernon Ohio United States 43050
    457 Licking Memorial Hospital Newark Ohio United States 43055
    458 Newark Radiation Oncology Newark Ohio United States 43055
    459 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    460 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    461 Springfield Regional Cancer Center Springfield Ohio United States 45504
    462 Springfield Regional Medical Center Springfield Ohio United States 45505
    463 ProMedica Flower Hospital Sylvania Ohio United States 43560
    464 ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo Ohio United States 43606
    465 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    466 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    467 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    468 Upper Valley Medical Center Troy Ohio United States 45373
    469 University Hospitals Sharon Health Center Wadsworth Ohio United States 44281
    470 Saint Joseph Warren Hospital Warren Ohio United States 44484
    471 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    472 Saint Ann's Hospital Westerville Ohio United States 43081
    473 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    474 UHHS-Westlake Medical Center Westlake Ohio United States 44145
    475 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    476 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    477 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    478 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    479 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    480 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    481 Saint Charles Health System Bend Oregon United States 97701
    482 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    483 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    484 Bay Area Hospital Coos Bay Oregon United States 97420
    485 Providence Newberg Medical Center Newberg Oregon United States 97132
    486 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    487 Providence Portland Medical Center Portland Oregon United States 97213
    488 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    489 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    490 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    491 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    492 Geisinger Medical Center Danville Pennsylvania United States 17822
    493 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    494 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    495 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    496 Jefferson Hospital Jefferson Hills Pennsylvania United States 15025
    497 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    498 Lewistown Hospital Lewistown Pennsylvania United States 17044
    499 Forbes Hospital Monroeville Pennsylvania United States 15146
    500 Thomas Jefferson University Hospital Philadelphia Pennsylvania United States 19107
    501 Allegheny General Hospital Pittsburgh Pennsylvania United States 15212
    502 West Penn Hospital Pittsburgh Pennsylvania United States 15224
    503 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    504 Community Medical Center Scranton Pennsylvania United States 18510
    505 Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania United States 17870
    506 Geisinger Medical Group State College Pennsylvania United States 16801
    507 Wexford Health and Wellness Pavilion Wexford Pennsylvania United States 15090
    508 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    509 Asplundh Cancer Pavilion Willow Grove Pennsylvania United States 19090
    510 Women and Infants Hospital Providence Rhode Island United States 02905
    511 Medical University of South Carolina Charleston South Carolina United States 29425
    512 Rapid City Regional Hospital Rapid City South Dakota United States 57701
    513 Avera Cancer Institute Sioux Falls South Dakota United States 57105
    514 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    515 Parkland Memorial Hospital Dallas Texas United States 75235
    516 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    517 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    518 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    519 Bon Secours Memorial Regional Medical Center Mechanicsville Virginia United States 23116
    520 Bon Secours Westchester Emergency Center Midlothian Virginia United States 23113
    521 Bon Secours Saint Francis Medical Center Midlothian Virginia United States 23114
    522 Bon Secours DePaul Medical Center Norfolk Virginia United States 23505
    523 Bon Secours Maryview Medical Center Portsmouth Virginia United States 23707
    524 Bon Secours Saint Mary's Hospital Richmond Virginia United States 23226
    525 Bon Secours Cancer Institute at Reynolds Crossing Richmond Virginia United States 23230
    526 Bon Secours Health Center at Harbour View Suffolk Virginia United States 23435
    527 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    528 Overlake Medical Center Bellevue Washington United States 98004
    529 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    530 Harrison Medical Center Bremerton Washington United States 98310
    531 Highline Medical Center-Main Campus Burien Washington United States 98166
    532 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    533 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    534 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    535 Providence Regional Cancer Partnership Everett Washington United States 98201
    536 Saint Francis Hospital Federal Way Washington United States 98003
    537 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    538 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    539 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    540 Saint Clare Hospital Lakewood Washington United States 98499
    541 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    542 Valley Medical Center Renton Washington United States 98055
    543 Pacific Gynecology Specialists Seattle Washington United States 98104
    544 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    545 Kaiser Permanente Washington Seattle Washington United States 98112
    546 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    547 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    548 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    549 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    550 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    551 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    552 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    553 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    554 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    555 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    556 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    557 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    558 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    559 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    560 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    561 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    562 Essentia Health-Hayward Clinic Hayward Wisconsin United States 54843
    563 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    564 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    565 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    566 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    567 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    568 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    569 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    570 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    571 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    572 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    573 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    574 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    575 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    576 Essentia Health-Spooner Clinic Spooner Wisconsin United States 54801
    577 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    578 Essentia Health Saint Mary's Hospital - Superior Superior Wisconsin United States 54880
    579 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    580 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    581 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    582 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    583 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    584 Billings Clinic-Cody Cody Wyoming United States 82414
    585 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • National Cancer Institute (NCI)
    • NRG Oncology

    Investigators

    • Principal Investigator: Ramez N Eskander, NRG Oncology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT03348631
    Other Study ID Numbers:
    • NCI-2017-02147
    • NCI-2017-02147
    • NRG-GY014
    • NRG-GY014
    • U10CA180868
    First Posted:
    Nov 21, 2017
    Last Update Posted:
    Aug 11, 2022
    Last Verified:
    Jun 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Carcinoma
    Adenocarcinoma
    Carcinoma, Endometrioid
    Adenocarcinoma, Clear Cell
    Recurrence

    Study Results

    No Results Posted as of Aug 11, 2022