The Findings of Magnetic Resonance Imaging in Subtypes of Tics-related Disorders

Sponsor

National Taiwan University Hospital (Other)

Overall Status

Recruiting

CT.gov ID

NCT05566496

Collaborator

(none)

500

Enrollment

Location

Anticipated Duration (Months)

5.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The findings of resting-state functional magnetic resonance imaging and diffusion spectrum imaging in subtypes of tics-related disorders

Condition or Disease	Intervention/Treatment	Phase
Tourette Syndrome in Children	Diagnostic Test: Brain MRI

Study Design

Study Type:

Observational

Anticipated Enrollment :

500 participants

Observational Model:

Case-Crossover

Time Perspective:

Retrospective

Official Title:

The Findings of Resting-state Functional Magnetic Resonance Imaging, Diffusion Spectrum Imaging, and Wideband Magnetic Resonance Imaging in Subtypes of Tics-related Disorders

Anticipated Study Start Date :

Oct 1, 2022

Anticipated Primary Completion Date :

Aug 1, 2025

Anticipated Study Completion Date :

Dec 1, 2030

Arms and Interventions

Arm	Intervention/Treatment
Tourette Age less than 18 years old Diagnosed as Tourette syndrome or chronic tic disorders No other neuropsychiatric disorders	Diagnostic Test: Brain MRI All participants receive brain MRI evaluation and clinical evaluation of tic severity.
Healthy Age less than 18 years old No other neuropsychiatric disorders	Diagnostic Test: Brain MRI All participants receive brain MRI evaluation and clinical evaluation of tic severity.

Arm

Intervention/Treatment

Tourette

Age less than 18 years old Diagnosed as Tourette syndrome or chronic tic disorders No other neuropsychiatric disorders

Diagnostic Test: Brain MRI

All participants receive brain MRI evaluation and clinical evaluation of tic severity.

Healthy

Age less than 18 years old No other neuropsychiatric disorders

Diagnostic Test: Brain MRI

All participants receive brain MRI evaluation and clinical evaluation of tic severity.

Outcome Measures

Primary Outcome Measures

Difference between healthy and Tourette group [2 years after enrollment for primary evaluation]
Difference of MRI result between healthy and Tourette group

Eligibility Criteria

Criteria

Ages Eligible for Study:

0 Years to 18 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Age less than 18 years old
Diagnosed as Tourette syndrome or chronic tic disorders

Exclusion Criteria:

History of neuropsychiatric disorders
Already receive treatment for Tourette syndrome/chronic tics disorder
Have some device not allowed for MRI scan

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	National Taiwan University Children Hospital Pediatric Neurology Department	Taipei		Taiwan	100

Sponsors and Collaborators

National Taiwan University Hospital

Investigators

Principal Investigator: Wang-Tso Lee, National Taiwan University Children Hospital Pediatric neurology department

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

National Taiwan University Hospital

ClinicalTrials.gov Identifier:

NCT05566496

Other Study ID Numbers:

201503062RIND

First Posted:

Oct 4, 2022

Last Update Posted:

Oct 5, 2022

Last Verified:

Sep 1, 2022

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by National Taiwan University Hospital

MRI

pediatric neurology

Additional relevant MeSH terms:

Tourette Syndrome

Study Results

No Results Posted as of Oct 5, 2022