Frequency and Risk Factors of Acute Myeloid Leukemia

Sponsor
Assiut University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05787951
Collaborator
(none)
200
27

Study Details

Study Description

Brief Summary

  1. to assess the frequency of acute myeloid leukemia at clinical Haematology unit of Assiute university hospital

  2. to study correlations of known risk factors and if there are new risk factors participate in increasing frequency of acute myeloid leukemia

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: Bone marrow aspirite for diagnosis

Detailed Description

Acute myeloid leukaemia (AML) is a rare heterogeneous disease comprising a group of hematopoietic neoplasms originating from the excessive clonal proliferation of myeloid pre- cursor cells [1]. Diagnosis of AML is based on morphological diagnosis with proliferation of blast cells ≥ 20% of bone marrow cells, flow cytometric analysis and cytogenetic abnormalities, including the t(8;21)(q22;q22), t(15;17) (q22;q12) and inv (16)(p13.1;q22) which are associated with longer remission and survival, while alterations of chromosomes 5, 7, complex karyotype and 11q23 are associated with poor response to therapy and shorter overall survival [2] The etiological agent and pathogenesis of AML are not entirely clear, only few AML cases can be accurately classified through traditional cellular morphological classification [3]It is the most common acute leukaemia in adults. It accounts for 1.3% of new cancer patients in the United States, in 2018[ 4] Some factors are well documented to increase the risk of some types of leukemia such as benzene exposure and ionizing radiation [5] increased frequency of acute myeloid leukemia has been noticed at Haematology unit so the aim of the study to assess the the frequency of acute myeloid leukemia and to evaluate the risk factors for it .

Study Design

Study Type:
Observational
Anticipated Enrollment :
200 participants
Observational Model:
Other
Time Perspective:
Prospective
Official Title:
Frequency and Risk Factors of Acute Myeloid Leukemia at Clinical Haemtology Unit of Assiut University Hospital
Anticipated Study Start Date :
May 1, 2023
Anticipated Primary Completion Date :
May 1, 2025
Anticipated Study Completion Date :
Aug 1, 2025

Outcome Measures

Primary Outcome Measures

  1. Frequency of acute myeloid leukemia at clinical Haemtology unit of Assiute university hospital [Two years]

Secondary Outcome Measures

  1. Risk factors of acute myeloid leukemia at clinical Haemtology unit of Assiute university hospital [Two years]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Adult Patients(above 18 years) diagnosed as acute myeloid leukemia according to WHO diagnostic criteria
Exclusion Criteria:
  • Patients with other types of leukemia

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Assiut University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Sanaa Ezzat Hussien, Sanaa Ezzat Hussien, Assiut University
ClinicalTrials.gov Identifier:
NCT05787951
Other Study ID Numbers:
  • Risk factors of AML
First Posted:
Mar 28, 2023
Last Update Posted:
Mar 28, 2023
Last Verified:
Mar 1, 2023
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Mar 28, 2023