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Functional Neuroimaging of Cortical Plasticity in the Human Visual System

Sponsor
Baylor College of Medicine (Other)
Overall Status
Withdrawn
CT.gov ID
NCT01062672
Collaborator
Brigham and Women's Hospital (Other)
0
Enrollment
2
Locations
83
Actual Duration (Months)
0
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury will be studied and compared to appropriate controls. Functional magnetic resonance imaging methods are used to monitor cortical topography in time. The main aims of the study are to determine: 1) what are the patterns of cortical reorganization that are seen spontaneously after injury, and 2) whether rehabilitative training can promote adaptive reorganization enhancing recovery.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    0 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Functional Neuroimaging of Cortical Plasticity in the Human Visual System
    Actual Study Start Date :
    Jan 1, 2009
    Actual Primary Completion Date :
    Dec 1, 2015
    Actual Study Completion Date :
    Dec 1, 2015

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • Stable lesion of the visual pathways resulting in a visual field scotoma.
      Exclusion Criteria:

      • Inability to undergo magnetic resonance imaging,

      • Inability to comply with basic instructions,

      • Inability to perform the behavioral tasks required,

      • Patients with chronic progressive neurological or psychiatric disorders,

      • Patients that are pregnant, or breast feeding.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Baylor College of Medicine Houston Texas United States 77030
      2 Max Planck Institute for Biological Cybernetics Tuebingen Germany

      Sponsors and Collaborators

      • Baylor College of Medicine
      • Brigham and Women's Hospital

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Eli M Mizrahi, Professor, Baylor College of Medicine
      ClinicalTrials.gov Identifier:
      NCT01062672
      Other Study ID Numbers:
      • H--22516
      First Posted:
      Feb 4, 2010
      Last Update Posted:
      Apr 11, 2022
      Last Verified:
      Apr 1, 2022
      Keywords provided by Eli M Mizrahi, Professor, Baylor College of Medicine
      plasticity
      reorganization
      cortical
      fMRI
      rehabilitation
      Additional relevant MeSH terms:
      Blindness

      Study Results

      No Results Posted as of Apr 11, 2022