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Cytokine Gene Polymorphisms in Gastric Diseases

Sponsor
Hamamatsu University (Other)
Overall Status
Unknown status
CT.gov ID
NCT00197470
Collaborator
Yokoyama Foundation for Clinical Pharmacology (Other)
1
Location

Study Details

Study Description

Brief Summary

Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. We intended to clarify the association between polymorphisms of pro-inflammatory and anti-inflammatory cytokines, and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.

Condition or Disease Intervention/Treatment Phase
  • Procedure: IL-1, TNF-alpha, Il-10
 N/A

Detailed Description

  1. pylori infection has close associations with the development of peptic ulcer diseases as well as gastric cancer, gastric adenoma, and gastric MALT lymphoma. The association of the host genetics with the susceptibility to various gastroduodenal disorders has been intensively investigated in the pathogenesis of peptic ulcer and gastric cancer by H. pylori infection .

In chronic active gastritis induced by H. pylori infection, activated neutrophils and mononuclear cells produce several pro-inflammatory and anti-inflammatory cytokines. In fact, levels of pro-inflammatory and anti-inflammatory cytokines are elevated in gastric mucosa infected with H. pylori.

Cytokine polymorphisms are associated with various inflammatory and autoimmune diseases. Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. However, the roles of the IL-10 polymorphisms on the pathogenesis of H. pylori-related gastric cancer and peptic ulcer have not been fully elucidated.It is unclear whether pro-inflammatory and anti-inflammatory cytokines polymorphisms were associated with pathogenesis of peptic ulcer and gastric cancer in Japan. Then, we intended to clarify the association between polymorphisms of IL-10 and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.

Study Design

Study Type:
Interventional
Allocation:
Randomized
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Diagnostic
Official Title:
Effects of Pro-Inflammatory and Anti-Inflammatory Cytokine Gene Polymorphism on the Development of Gastric Cancer and Peptic Ulcer in Japanese
Study Start Date :
Jan 1, 2000

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    0 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    Exclusion Criteria:
    • patinets without H. pylori

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Hamamatsu University School of Medicine Hamamatsu Japan 431-3192

    Sponsors and Collaborators

    • Hamamatsu University
    • Yokoyama Foundation for Clinical Pharmacology

    Investigators

    • Study Chair: MItsushige Sugimoto, First department of medicine, Hamamatsu University School of medicine

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00197470
    Other Study ID Numbers:
    • Mitsu-001
    First Posted:
    Sep 20, 2005
    Last Update Posted:
    Sep 20, 2005
    Last Verified:
    Sep 1, 2005
    Additional relevant MeSH terms:
    Stomach Neoplasms
    Stomach Ulcer
    Duodenal Ulcer
    Ulcer

    Study Results

    No Results Posted as of Sep 20, 2005