GICCA: GastroIntestinal Cancer in Children and Adolescents
Study Details
Study Description
Brief Summary
The goal of this observational population-based cohort study is to investigate the clinical characteristics and outcomes of children and adolescents with primary gastrointestinal malignancies registered in the publicly available Surveillance, Epidemiology, and End Results (SEER) 17 database during 2000-2019.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The investigators aim to describe the patient and tumor characteristics, treatments, and outcomes of children and adolescents diagnosed with primary gastrointestinal malignancies, and to analyze these data for trends over time. In addition, the investigators want to explore independent prognostic factors for overall survival. Finally, the investigators want to describe subsequent primary malignancies diagnosed among patients from the study cohort, as well as to calculate their risk of developing a second primary cancer relative to the general population. Data on children (aged 0-17 years at diagnosis) and young people aged 18-24 years at diagnosis are analyzed separately. Special focus is laid on patients with primary carcinomas of the gastrointestinal tract; particularly colorectal carcinoma.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Children Patients aged 0-17 years at primary gastrointestinal cancer diagnosis |
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Young people aged 18-24 years Patients aged 18-24 years at primary gastrointestinal cancer diagnosis |
Outcome Measures
Primary Outcome Measures
- Overall survival [2000-2019]
Defined as the time between the date of diagnosis and the date of death from any cause (event) or date of last follow-up.
Secondary Outcome Measures
- Standardized incidence of second primary malignancies [2000-2019]
Standardized incidence of second primary malignancies in patients who survived (i) two or more months, or (ii) five or more years after initial gastrointestinal cancer diagnosis, relative to the general population.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age at primary gastrointestinal cancer diagnosis <25 years
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Diagnosis of a primary gastrointestinal malignancy as an individual's first primary malignancy
Exclusion Criteria:
- None
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Leiden University Medical Center | Leiden | South-Holland | Netherlands | 2333ZA |
2 | Juliana Children's Hospital | The Hague | South-Holland | Netherlands | 2545 AA |
Sponsors and Collaborators
- Paul G. Kemps, MD
- Juliana Children's Hospital
Investigators
- Principal Investigator: Paul G. Kemps, MD, Leiden University Medical Center
Study Documents (Full-Text)
More Information
Publications
None provided.- nWMO-D4-2022-031