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MVP: Genetic Basis of Mitral Valve Prolapse

Sponsor
Massachusetts General Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT01719211
Collaborator
Leducq Foundation (Other)
1,500
Enrollment
1
Location
323
Duration (Months)
4.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    This is a genome-wide association study.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    1500 participants
    Observational Model:
    Other
    Time Perspective:
    Prospective
    Official Title:
    Genetic Basis of Mitral Valve Prolapse
    Study Start Date :
    Jan 1, 1999
    Anticipated Primary Completion Date :
    Dec 1, 2025
    Anticipated Study Completion Date :
    Dec 1, 2025

    Outcome Measures

    Primary Outcome Measures

    1. Discovery of the genetic basis of Mitral Valve Prolapse [5 years]

      Genome-wide association

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Mitral valve prolapse
    Exclusion Criteria:
    • Other mitral valve diseases

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Mass General Hospital Boston Massachusetts United States 02114

    Sponsors and Collaborators

    • Massachusetts General Hospital
    • Leducq Foundation

    Investigators

    • Principal Investigator: robert a levine, MD, Mass. General Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Robert A. Levine, MD, Cardiologist, Massachusetts General Hospital
    ClinicalTrials.gov Identifier:
    NCT01719211
    Other Study ID Numbers:
    • 1999-p-007948
    First Posted:
    Nov 1, 2012
    Last Update Posted:
    Mar 1, 2021
    Last Verified:
    Feb 1, 2021
    Keywords provided by Robert A. Levine, MD, Cardiologist, Massachusetts General Hospital
    MVP, mitral valve
    Additional relevant MeSH terms:
    Mitral Valve Prolapse
    Prolapse

    Study Results

    No Results Posted as of Mar 1, 2021