Genomic Evolution of Metastasis in Gastric Cancer
Study Details
Study Description
Brief Summary
The aim of this study is to track tumor evolution of regional and distant metastases in gastric cancer using the Next Generation Sequencing technologies.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Gastric cancer is the fourth most common cancer in Vietnam with high mortality rate. Metastasis is the leading cause of death in gastric cancer patients, with median overall survival of less than 1 year. Currently, there is no effective treatment because the molecular mechanism of metastasis remains unclear. The aim of this study is to use advanced NGS technologies to dissect the genomic changes (genetic, epigenetic and transcriptional changes) of the primary tumor and associated metastatic sites of the same patients. With that, the investigators can reconstruct the clonal evolution from primary tumor to metastasis, identify key pathways governing metastasis development that can be targeted for future therapeutic development.
Study Design
Outcome Measures
Primary Outcome Measures
- Genetic and epigenetic changes of the tumor [3 months after surgery]
Ultra-deep NGS of the primary tumor and associated metastatic sites from the same patients to identify mechanism governing metastasis development
Eligibility Criteria
Criteria
Inclusion Criteria:
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Male or Female patients aged 18 years and older
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Histologically proven primary gastric adenocarcinoma and clinical evidence of metastasis (N1-3M1)
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Biopsies can be taken at multiple sites
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No known other concomitant cancer diagnosis
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Signed informed consent
Exclusion Criteria:
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Gastric adnocarcinoma cannot be confirmed primary
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Unable to undergo biopsy or surgery
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University Medical Center Ho Chi Minh City | Ho Chi Minh City | Vietnam | 700000 |
Sponsors and Collaborators
- University Medical Center Ho Chi Minh City (UMC)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 80/GCN-HDDD 2021