Genomics and Prognosis in GI Cancers
Study Details
Study Description
Brief Summary
This study aims to collect biospecimens and explore the correlation of genomics and prognosis in alimentary tract cancers.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
In this study, we will collect clinical specimens of alimentary tract cancers and perform DNA and RNA analysis to identify genetic alterations for the development of a comprehensive somatic mutation databases and investigate their potential correlation with clinical, radiological and pathological variables. The genomics study included but not limited to target gene panel sequencing, whole exome sequencing, whole genome sequencing, bulk RNA sequencing, single cell RNA sequencing and metagenomics.
Study Design
Outcome Measures
Primary Outcome Measures
- Number of subjects who still survive at 1 year [1 year]
1 year overall survival rate
Eligibility Criteria
Criteria
Inclusion Criteria:
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Able to sign the informed consent
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Age >= 20
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Histology proved pancreatic cancer, esophageal cancer, gastric cancer, hepatocellular carcinoma, cholangiocarcinoma, colorectal cancer
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Agree to provide tumor/normal tissue including but not limited to surgical specimen, biopsy, cytology specimen, bile, urine or stool
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Agree to receive blood sampling 20ml at first time and 10ml during each follow-up (total sampling amount no more than 30ml per month)
Exclusion Criteria:
- Cannot cooperate with blood sampling
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | National Cheng-Kung University Hospital | Tainan | Taiwan | ||
2 | National Institute of Cancer Research | Tainan | Taiwan |
Sponsors and Collaborators
- National Health Research Institutes, Taiwan
- National Cheng-Kung University Hospital
Investigators
- Principal Investigator: Li-Tzong Chen, MD PhD, National Health Research Institutes, Taiwan
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- A-ER-109-073