GLIM-defined Malnutrition Criteria for Postoperative Outcomes in Patients With Esophagogastric Cancer
Study Details
Study Description
Brief Summary
The present study aims to investigate the prognostic value of preoperative fat-free mass index for postoperative outcomes in patients undergoing esophagogastric cancer surgery, and to explore the role of the FFMI in the Global Leadership Initiative on Malnutrition (GLIM) criteria.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The GLIM criteria of malnutrition as a consensus lack of optimal combination in clinical validation. After the publication of the GLIM consensus, few studies have examined the effect of reduced FFMI on the clinical prognosis of patients with esophagogastric cancer, and whether the FFMI can be used as an effective diagnostic criterion of malnutrition in esophagogastric cancer needs to be further studied.
Therefore, the present study aims were to investigate the prognostic value of preoperative fat-free mass index for postoperative outcomes in patients undergoing esophagogastric cancer surgery, and to explore the role of the FFMI in the GLIM consensus for malnutrition.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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The normal FFMI group The FFMI was calculated as follows: FFMI = fat-free mass (kg)/height squared (m2). FFMI cut-off values (derived from BIA measurements, </≥15 kg/m2 for females and </≥17 kg/m2 for males). Patients with esophagogastric cancer were then divided into the normal FFMI group (FFMI ≥17 kg/m2 for male and FFMI ≥15 kg/m2 for female). |
Other: no intervention
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The low FFMI group The FFMI was calculated as follows: FFMI = fat-free mass (kg)/height squared (m2). FFMI cut-off values (derived from BIA measurements, </≥15 kg/m2 for females and </≥17 kg/m2 for males). Patients with esophagogastric cancer were then divided into the low FFMI group (FFMI <17 kg/m2 for male and FFMI <15 kg/m2 for female). |
Other: no intervention
|
Outcome Measures
Primary Outcome Measures
- postoperative complications [Within 60 days after surgery]
postoperative complications (infectious complications and noninfectious complications)
Secondary Outcome Measures
- length of stay (LOS) [Within 60 days after surgery]
length of stay (LOS)
- wound healing time [Within 60 days after surgery]
wound healing time
- postoperative antibiotic time [Within 60 days after surgery]
postoperative antibiotic time
- nutritional status [up to 4 weeks]
nutritional status ( such as: weight,albumin,prealbumin)
- hospitalization cost [Within 60 days after surgery]
hospitalization cost(including: surgery and medicine costs)
Eligibility Criteria
Criteria
Inclusion Criteria:
Elective surgery for esophagogastric cancer (there was a clear pathological diagnosis before surgery); NRS2002≥3; Preoperative BIA examination was performed.
Exclusion Criteria:
Discharged from a hospital within 24 hours; No BIA examination and not suitable for BIA examination (such as ascites, edema, amputation and pace-maker); Hepatic insufficiency (alanine transaminase/aspartate transaminase ratio 200% above normal range or bilirubin>3mg/dL) ; Renal insufficiency (serum creatinine>1.5mg/dL); Emergency operation; Pregnancy; Missing the postoperative information follow-up data.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Jinling Hospital, China
- Jiangsu Cancer Institute & Hospital
- Subei People's Hospital of Jiangsu Province
- Peking Union Medical College
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- JinlingHospital-1
- 201502022