Global Cardiovascular Risk Consortium

Sponsor

Universitätsklinikum Hamburg-Eppendorf (Other)

Overall Status

Completed

CT.gov ID

NCT05466825

Collaborator

(none)

1,596,155

Enrollment

Location

29.1

Actual Duration (Months)

54772.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The Global Cardiovascular Risk Consortium (GCVRC) comprises harmonized data from nearly 1.7 Mio individuals of 126 cohorts across 43 countries and aims to elucidate the distribution of five major cardiovascular risk factors (body mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and their impact on cardiovascular disease (CVD) by geographical region and sex.

Condition or Disease	Intervention/Treatment	Phase
Cardiovascular Diseases Heart Diseases Coronary Disease Myocardial Infarction Angina, Unstable Stroke Myocardial Revascularization

Detailed Description

Previous literature reported a small number of modifiable risk factors that might explain up to 90% of certain CVD subtypes. If and to what extent regional differences in risk factor levels contribute to new-onset CVD remains to be elucidated.

In the Global Cardiovascular Risk Consortium (GCVRC) we focus on five major cardiovascular risk factors: Body mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes. We aim to show the extent to which the distribution, population attributable risk, and predictive value of these factors differ geographically and by sex. Understanding of these issues is essential to guide regionally effective CVD prevention and therapy strategies, to determine residual risk, and to improve global cardiovascular health.

The GCVRC uses individual-level harmonized data from nearly 1.7 million individuals in 126 cohorts across 43 countries, categorized in 8 geographical regions (based on amodification of WHO regions) - North America, Latin America, Sub-Saharan Africa, North Africa and Middle East, Western Europe, Eastern Europe and Russia, Asia, Oceania.

Cox regression analyses and population attributable fractions (PAFs) for 10-year incident CVD are calculated for the five risk factors by geographical region and sex to determine the percentage of CVD burden that may be preventable by control of these risk factors.

The results will influence regionally adapted prevention strategies to reduce the global CVD burden.

Study Design

Study Type:

Observational

Actual Enrollment :

1596155 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Impact of Modifiable Cardiovascular Risk Factors on Incident Cardiovascular Disease by Geographical Region and Sex

Actual Study Start Date :

Sep 20, 2019

Actual Primary Completion Date :

Feb 23, 2022

Actual Study Completion Date :

Feb 23, 2022

Outcome Measures

Primary Outcome Measures

Cardiovascular disease (CVD) [5-7 years of follow-up]
Non-fatal myocardial infarction, ischemic heart disease death, unstable angina pectoris, cardiac revascularization, unclassifiable death, fatal and non-fatal stroke (any type).

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

population-based cohort: individuals with information on the traditional CVD risk factors including body mass index (BMI), systolic blood pressure (SBP), non-high-density lipoprotein cholesterol (non-HDL-C), current smoking, and diabetes, as well as the outcome fatal or non-fatal CVD.