Obinutuzumab With or Without Umbralisib, Lenalidomide, or Combination Chemotherapy in Treating Patients With Relapsed or Refractory Grade I-IIIa Follicular Lymphoma

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Suspended
CT.gov ID
NCT03269669
Collaborator
(none)
103
423
3
64.7
0.2
0

Study Details

Study Description

Brief Summary

This phase II trial studies how well obinutuzumab with or without umbralisib, lenalidomide, or combination chemotherapy work in treating patients with grade I-IIIa follicular lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Immunotherapy with obinutuzumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Umbralisib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as lenalidomide, use substances made from living organisms that may stimulate or suppress the immune system in different ways and stop cancer cells from growing. Chemotherapy drugs, such as cyclophosphamide, doxorubicin, vincristine, prednisone, and bendamustine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving obinutuzumab with or without umbralisib, lenalidomide, or combination chemotherapy will work better in treating patients with grade I-IIIa follicular lymphoma.

Condition or Disease Intervention/Treatment Phase
Phase 2

Detailed Description

PRIMARY OBJECTIVE:
  1. To compare the complete response rate up to 6 cycles after randomization as defined by centrally read positron emission tomography (PET)/computed tomography (CT) (integral biomarker) of 2 targeted therapeutic regimens (obinutuzumab + umbralisib [TGR-1202] or obinutuzumab + lenalidomide) with obinutuzumab + chemotherapy (cyclophosphamide, doxorubicin hydrochloride [doxorubicin], vincristine sulfate [vincristine], and prednisone [CHOP] or bendamustine hydrochloride [bendamustine]) in patients with early relapsing or refractory follicular lymphoma.
SECONDARY OBJECTIVES:
  1. To validate the prognostic association of the m7-FLIPI model, demonstrating that the population of follicular lymphoma patients who respond poorly to chemoimmunotherapy are enriched for having a high-risk m7-FLIPI score, and that the score is associated with progression-free survival (integrated biomarker). (Primary translational medicine) II. To estimate the 30-month sustained complete response rate (CR30) defined by centrally read PET/CT with each of the regimens in this early relapsing or refractory follicular lymphoma population.

  2. To estimate best response up to 12 cycles of therapy, progression free survival, duration of response and overall survival with each of the combinations in early relapsing or refractory follicular lymphoma.

  3. To evaluate the adverse effects of each of the regimens in early relapsing or refractory follicular lymphoma.

  4. To evaluate the predictive performance of non-invasive genotyping (m7-FLIPI in circulating tumor deoxyribonucleic acid [DNA]) of plasma at study entry relative to standard tumor genotyping (m7-FLIPI) of formalin-fixed paraffin-embedded tumor tissue.

  5. To evaluate the association between the detection of active lymphoma by PET-CT and the detection of circulating tumor DNA in plasma at baseline, after 6 and 12 cycles, and at 30 months after initiation of study therapy.

OUTLINE: Patients are randomized to 1 of 3 arms.

ARM I: Patients receive obinutuzumab intravenously (IV) on day 1 and umbralisib orally (PO) daily on days 1-28. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive obinutuzumab IV on day 1 and lenalidomide PO on days 1-21. Treatment repeats every 28 days for up 12 cycles in the absence of disease progression or unacceptable toxicity.

ARM III:

PRIOR BENDAMUSTINE-BASED CHEMOTHERAPY: Patients receive obinutuzumab IV on day 1, cyclophosphamide IV on day 1, doxorubicin IV on day 1, vincristine IV on day 1, and prednisone PO on days 1-5. Treatment with obinutuzumab repeats every 21 or 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Treatment with combination chemotherapy repeats every 21 days for 6 cycles in the absence of disease progression or unacceptable toxicity.

PRIOR CHOP CHEMOTHERAPY: Patients receive obinutuzumab IV on day 1 and bendamustine IV over 60 minutes on days 1 and 2. Treatment repeats every 28 days for up to 6 or 12 cycles (bendamustine and obinutuzumab, respectively) in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
103 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Randomized Phase II Trial in Early Relapsing or Refractory Follicular Lymphoma
Actual Study Start Date :
Aug 10, 2017
Anticipated Primary Completion Date :
Dec 31, 2022
Anticipated Study Completion Date :
Dec 31, 2022

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm I (obinutuzumab, umbralisib)

Patients receive obinutuzumab IV on day 1 and umbralisib PO daily on days 1-28. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

Biological: Obinutuzumab
Given IV
Other Names:
  • Anti-CD20 Monoclonal Antibody R7159
  • GA-101
  • GA101
  • Gazyva
  • huMAB(CD20)
  • R7159
  • RO 5072759
  • RO-5072759
  • RO5072759
  • Drug: Umbralisib
    Given PO
    Other Names:
  • 2-((1S)-1-(4-Amino-3-(3-fluoro-4-(1-methylethoxy)phenyl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-1-benzopyran-4-one
  • RP-5264
  • RP5264
  • TGR-1202
  • Experimental: Arm II (obinutuzumab, lenalidomide)

    Patients receive obinutuzumab IV on day 1 and lenalidomide PO on days 1-21. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

    Drug: Lenalidomide
    Given PO
    Other Names:
  • CC-5013
  • CC5013
  • CDC 501
  • Revlimid
  • Biological: Obinutuzumab
    Given IV
    Other Names:
  • Anti-CD20 Monoclonal Antibody R7159
  • GA-101
  • GA101
  • Gazyva
  • huMAB(CD20)
  • R7159
  • RO 5072759
  • RO-5072759
  • RO5072759
  • Active Comparator: Arm III (obinutuzumab, combination chemotherapy)

    PRIOR BENDAMUSTINE-BASED CHEMOTHERAPY: Patients receive obinutuzumab IV on day 1, cyclophosphamide IV on day 1, doxorubicin IV on day 1, vincristine IV on day 1, and prednisone PO on days 1-5. Treatment with obinutuzumab repeats every 21 or 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Treatment with combination chemotherapy repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. PRIOR CHOP CHEMOTHERAPY: Patients receive obinutuzumab IV on day 1, and bendamustine IV over 1 hour on days 1 and 2. Treatment repeats every 28 days for up to 6 or 12 cycles (bendamustine and obinutuzumab, respectively) in the absence of disease progression or unacceptable toxicity.

    Drug: Bendamustine Hydrochloride
    Given IV
    Other Names:
  • Belrapzo
  • Bendamustin Hydrochloride
  • Bendeka
  • Cytostasan Hydrochloride
  • Levact
  • Ribomustin
  • SyB L-0501
  • Treanda
  • Drug: Cyclophosphamide
    Given IV
    Other Names:
  • (-)-Cyclophosphamide
  • 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
  • Carloxan
  • Ciclofosfamida
  • Ciclofosfamide
  • Cicloxal
  • Clafen
  • Claphene
  • CP monohydrate
  • CTX
  • CYCLO-cell
  • Cycloblastin
  • Cycloblastine
  • Cyclophospham
  • Cyclophosphamid monohydrate
  • Cyclophosphamide Monohydrate
  • Cyclophosphamidum
  • Cyclophosphan
  • Cyclophosphane
  • Cyclophosphanum
  • Cyclostin
  • Cyclostine
  • Cytophosphan
  • Cytophosphane
  • Cytoxan
  • Fosfaseron
  • Genoxal
  • Genuxal
  • Ledoxina
  • Mitoxan
  • Neosar
  • Revimmune
  • Syklofosfamid
  • WR- 138719
  • Drug: Doxorubicin Hydrochloride
    Given IV
    Other Names:
  • 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)
  • ADM
  • Adriacin
  • Adriamycin
  • Adriamycin Hydrochloride
  • Adriamycin PFS
  • Adriamycin RDF
  • ADRIAMYCIN, HYDROCHLORIDE
  • Adriamycine
  • Adriblastina
  • Adriblastine
  • Adrimedac
  • Chloridrato de Doxorrubicina
  • DOX
  • DOXO-CELL
  • Doxolem
  • Doxorubicin HCl
  • Doxorubicin.HCl
  • Doxorubin
  • Farmiblastina
  • FI 106
  • FI-106
  • hydroxydaunorubicin
  • Rubex
  • Biological: Obinutuzumab
    Given IV
    Other Names:
  • Anti-CD20 Monoclonal Antibody R7159
  • GA-101
  • GA101
  • Gazyva
  • huMAB(CD20)
  • R7159
  • RO 5072759
  • RO-5072759
  • RO5072759
  • Drug: Prednisone
    Given PO
    Other Names:
  • .delta.1-Cortisone
  • 1, 2-Dehydrocortisone
  • Adasone
  • Cortancyl
  • Dacortin
  • DeCortin
  • Decortisyl
  • Decorton
  • Delta 1-Cortisone
  • Delta-Dome
  • Deltacortene
  • Deltacortisone
  • Deltadehydrocortisone
  • Deltasone
  • Deltison
  • Deltra
  • Econosone
  • Lisacort
  • Meprosona-F
  • Metacortandracin
  • Meticorten
  • Ofisolona
  • Orasone
  • Panafcort
  • Panasol-S
  • Paracort
  • Perrigo Prednisone
  • PRED
  • Predicor
  • Predicorten
  • Prednicen-M
  • Prednicort
  • Prednidib
  • Prednilonga
  • Predniment
  • Prednisone Intensol
  • Prednisonum
  • Prednitone
  • Promifen
  • Rayos
  • Servisone
  • SK-Prednisone
  • Drug: Vincristine Sulfate
    Given IV
    Other Names:
  • Kyocristine
  • Leurocristine Sulfate
  • Leurocristine, sulfate
  • Oncovin
  • Vincasar
  • Vincosid
  • Vincrex
  • Vincristine, sulfate
  • Outcome Measures

    Primary Outcome Measures

    1. Complete response (CR) [Up to 6 cycles]

    Secondary Outcome Measures

    1. Sustained complete response rate (CR30) [Up to 30 months]

      Defined by centrally read positron emission tomography (PET)/computed tomography (CT).

    2. Progression-free survival (PFS) [From date of registration to date of first observation of progressive disease, or death due to any cause, assessed up to 5 years]

      Will be calculated using the method of Kaplan-Meier. 95% confidence for the survival estimates will be constructed using the method of Brookmeyer-Crowley. With 31 eligible patients in each arm, progression free survival at a particular time point, and the 30-month sustained response rate can be estimated to within at least +/- 18% with 95% confidence.

    3. Duration of response (CR, partial response [PR]) [From date of first documentation of response to treatment (CR, PR) to date of first documentation of progression, or death due to any cause, assessed up to 5 years]

      Will be calculated using the method of Kaplan-Meier.

    4. Overall survival (OS) [Up to 5 years]

      Will be calculated using the method of Kaplan-Meier. 95% confidence for the survival estimates will be constructed using the method of Brookmeyer-Crowley. With 31 eligible patients in each arm, OS at a particular time point, and the 30-month sustained response rate can be estimated to within at least +/- 18% with 95% confidence.

    5. Incidence of adverse events [Up to 5 years]

      Assessed by National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 (version 5.0 will be utilized for serious adverse events reporting only). Toxicity rates can be estimated to within at least +/- 18% with 95% confidence.

    6. Non-invasive genotyping and circulating tumor deoxyribonucleic acid (DNA) assessment [Up to 5 years]

      Sensitivity, specificity, positive predictive value, negative predictive value, and kappa coefficient will be used to evaluate the concordance. Will evaluate the association of detection of active lymphoma by positron emission tomography-computed tomography and the detection of circulating tumor DNA in plasma at baseline, after 6 and 12 cycles, and at 30 months after initiation of study therapy. Chi-square test will be used to evaluate the association and odds ratio will be calculated

    7. Active lymphoma and circulating tumor DNA in plasma [From baseline up to 30 months after initiation of treatment]

      The Cox proportional hazards model will be used to assess the association and odds ratio will be calculated.

    8. m7-FLIPI model validation [Up to 5 years]

      The Cox proportional hazards model will be used to assess the association of the m7-FLIPI with to PFS.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Patients must have follicular lymphoma (grade I, II or IIIa) confirmed at initial diagnosis and at relapse with identifiable fludeoxyglucose F-18 (FDG) avid disease on PET/CT; patients that have involvement with large cell lymphoma are not eligible

    • Patients must not have clinical evidence of central nervous system involvement by lymphoma since the proposed treatment strategies are not designed to address central nervous system (CNS) involvement adequately; if performed, any laboratory or radiographic tests performed to assess CNS involvement must be negative

    • Patients must have a whole body or limited whole body PET/CT scan performed within 42 days prior to registration

    • Patients must have bone marrow biopsy performed within 42 days prior to registration

    • All disease must be assessed and documented on the S1608 FDG-PET/CT assessment form

    • The intent is to enroll patients with FL relapsed within 2 years of completing their first course of chemotherapy (CHOP or bendamustine based therapy) + anti-CD20 therapy. Patient is still eligible if he/she received radiation therapy or anti-CD20 therapy prior to chemoimmunotherapy or if maintenance anti-CD20 therapy was administered after chemoimmunotherapy

    • Patients must have either failed to achieve a complete remission, or must have relapsed within 2 years after completing CHOP or bendamustine-containing chemoimmunotherapy (including an anti-CD20 monoclonal antibody), as measured from the last dose of CHOP or bendamustine; relapsed patients must not have received any intervening chemotherapy

    • Patients must have received only 1 course of chemotherapy, containing at least 3 cycles of CHOP or bendamustine; (note that no minimum dose of bendamustine is required)

    • Patients who received any anti-CD20 antibody therapy prior to CHOP or bendamustine are eligible

    • Patients who additionally received any maintenance anti-CD-20 antibody therapy or consolidative radioimmunotherapy within 2 years of the last dose of the CHOP or bendamustine therapy are eligible

    • Involved field or involved site radiation is not considered a line of therapy; examples of eligible prior treatment regimens (note this list is not all inclusive):

    • 1st line rituximab treatment followed years later by bendamustine rituximab x 4 cycles

    • Bendamustine rituximab x 4 cycles

    • 1st line rituximab treatment, 2nd line ibritumomab tiuxetan, followed by bendamustine bortezomib rituximab x 6 cycles followed by rituximab maintenance

    • Bendamustine obinutuzumab x 3 cycles

    • CHOP rituximab x 6 cycles followed by rituximab maintenance

    • For all forms of systemic therapy, patients must have completed therapy at least 21 days prior to registration; patients must have completed any radioimmunotherapy at least 84 days prior to registration; patients prior treatment related toxicities (except alopecia) must have resolved to Grade 1 or less prior to registration

    • Patients must not have any prior treatment with any PI3K inhibitor, or lenalidomide

    • Patients must have tissue specimens collected prior to registration; patients must be offered participation in biobanking of residual specimens; with patient consent, residuals from the mandatory submission will be banked for future research

    • Patients must be >= 18 years of age

    • All patients must have a Zubrod performance status of 0, 1 or 2

    • Absolute neutrophil count (ANC) >= 1,500/mcL within 28 days prior to registration

    • Platelets >= 75,000/mcL within 28 days prior to registration

    • Patients must have adequate renal function as documented by a calculated creatinine clearance >= 60 mL/min, within 28 days prior to registration

    • Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (=< 5 x IULN if secondary to lymphoma, Gilbert's syndrome, or medication related [e.g., indinavir, tenofovir, atazanavir]) within 28 days prior to registration

    • Direct bilirubin =< 1.5 x IULN (=< 5 x IULN if secondary to lymphoma) within 28 days prior to registration

    • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (=< 5 x IULN secondary to lymphoma) within 28 days prior to registration

    • Patients must have an echocardiogram (ECHO) or multigated acquisition (MUGA) scan within 42 days prior to registration with a cardiac ejection fraction >= 45%

    • Patients with hepatitis B virus infection must have undetectable hepatitis B virus (HBV) on suppressive therapy and no evidence of HBV-related hepatic damage; patients with hepatitis C virus infection are eligible if complete eradication therapy has been successfully completed, and there is no detectable hepatitis C virus (HVC) or related hepatic damage; patients with known human immunodeficiency virus (HIV) infection are eligible if they meet all of the following criteria in addition to the other protocol eligibility criteria:

    • Patient must have no history of acquired immune deficiency syndrome (AIDS)-related complications, other than a history of low CD4+ T-cell count (< 200/mm^3) prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to leukemia and should not be used as an exclusion criterion if low

    • Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the leukemia

    • Patient must have serum HIV viral load of < 200 copies/mm^3

    • Patient must be on combination antiretroviral therapy with minimal pharmacokinetic interactions with study therapy and minimal overlapping clinical toxicity with protocol therapy; (recommend a regimen of the integrase inhibitor dolutegravir combined with either disoproxil fumarate/emtricitabine or dolutegravir combined with tenofovir alafenamide/emtricitabine)

    • Protease inhibitors and once daily formulations containing cobicistat are NOT allowed due to potential pharmacokinetic interactions with leukemia therapy

    • Stavudine and zidovudine (AZT) are NOT allowed because of overlapping toxicity with protocol therapy

    • Patients must be able and willing to receive prophylaxis with daily aspirin, low molecular weight heparin, factor X inhibitors or warfarin if randomized to lenalidomide; patients must also be willing to receive pneumocystis jirovecii prophylaxis with sulfamethoxazole/trimethoprim, dapsone, atovaquone or inhaled pentamidine, in the event that they are randomized to TGR-1202; patients unable or unwilling to take any listed prophylaxis are NOT eligible

    • Patients must be able to discontinue CYP2C9 substrates with a narrow therapeutic index (e.g. warfarin, phenytoin), if randomized to TGR-1202; patients must discontinue such agents at least 1 week or 5 half-lives prior to beginning protocol therapy (whichever is longer)

    • No second prior malignancy is allowed except for adequately treated basal (or squamous cell) skin cancer, in situ cervical cancer or other cancer for which the patient has been disease free for three years

    • Patients must have a complete history and physical examination within 28 days prior to registration

    • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days and again within 24 hours prior to starting cycle 1 of lenalidomide; further, they must either commit to complete abstinence (true abstinence is acceptable when this is in line with the preferred and usual lifestyle of the subject; periodic abstinence [e.g., calendar, ovulation, symptothermal or post ovulation methods] and withdrawal are not acceptable methods of contraception) from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; while taking lenalidomide, during dose interruptions, and for at least 28 days after the last dose of lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy; a FCBP is a female who: 1) has achieve menarche at some point;

    1. has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); all patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure; NOTE: patients not randomized to receive lenalidomide will not be required to undergo serial pregnancy testing or lenalidomide counseling after registration
    • Patients must have lactate dehydrogenase (LDH) and beta-2-microglobulin collected within 28 days prior to registration

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

    • As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    2 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    3 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    4 Anchorage Oncology Centre Anchorage Alaska United States 99508
    5 Katmai Oncology Group Anchorage Alaska United States 99508
    6 Providence Alaska Medical Center Anchorage Alaska United States 99508
    7 Banner University Medical Center - Tucson Tucson Arizona United States 85719
    8 University of Arizona Cancer Center-North Campus Tucson Arizona United States 85719
    9 Kaiser Permanente-Anaheim Anaheim California United States 92806
    10 Kaiser Permanente-Deer Valley Medical Center Antioch California United States 94531
    11 PCR Oncology Arroyo Grande California United States 93420
    12 Sutter Auburn Faith Hospital Auburn California United States 95602
    13 Kaiser Permanente-Baldwin Park Baldwin Park California United States 91706
    14 Kaiser Permanente-Bellflower Bellflower California United States 90706
    15 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    16 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    17 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    18 Kaiser Permanente Dublin Dublin California United States 94568
    19 Kaiser Permanente-Fontana Fontana California United States 92335
    20 Kaiser Permanente-Fremont Fremont California United States 94538
    21 Kaiser Permanente-Fresno Fresno California United States 93720
    22 Kaiser Permanente - Harbor City Harbor City California United States 90710
    23 Kaiser Permanente-Irvine Irvine California United States 92618
    24 Loma Linda University Medical Center Loma Linda California United States 92354
    25 Kaiser Permanente Los Angeles Medical Center Los Angeles California United States 90027
    26 Kaiser Permanente West Los Angeles Los Angeles California United States 90034
    27 Memorial Medical Center Modesto California United States 95355
    28 Kaiser Permanente-Modesto Modesto California United States 95356
    29 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    30 Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California United States 94040
    31 Kaiser Permanente Oakland-Broadway Oakland California United States 94611
    32 Kaiser Permanente-Oakland Oakland California United States 94611
    33 Kaiser Permanente-Ontario Ontario California United States 91761
    34 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    35 VA Palo Alto Health Care System Palo Alto California United States 94304
    36 Kaiser Permanente - Panorama City Panorama City California United States 91402
    37 Eisenhower Medical Center Rancho Mirage California United States 92270
    38 Kaiser Permanente-Richmond Richmond California United States 94801
    39 Kaiser Permanente-Roseville Roseville California United States 95661
    40 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    41 Sutter Medical Center Sacramento Sacramento California United States 95816
    42 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    43 Kaiser Permanente - Sacramento Sacramento California United States 95825
    44 Kaiser Permanente-San Diego Mission San Diego California United States 92108
    45 Kaiser Permanente-San Diego Zion San Diego California United States 92120
    46 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    47 Kaiser Permanente-San Francisco San Francisco California United States 94115
    48 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    49 Kaiser Permanente San Leandro San Leandro California United States 94577
    50 Kaiser Permanente-San Marcos San Marcos California United States 92078
    51 Kaiser Permanente-San Rafael San Rafael California United States 94903
    52 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    53 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    54 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    55 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
    56 Sutter Pacific Medical Foundation Santa Rosa California United States 95403
    57 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    58 Kaiser Permanente-Stockton Stockton California United States 95210
    59 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    60 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    61 Kaiser Permanente-Vallejo Vallejo California United States 94589
    62 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    63 Kaiser Permanente-Woodland Hills Woodland Hills California United States 91367
    64 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
    65 The Medical Center of Aurora Aurora Colorado United States 80012
    66 Boulder Community Hospital Boulder Colorado United States 80301
    67 Rocky Mountain Cancer Centers-Boulder Boulder Colorado United States 80304
    68 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    69 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    70 Denver Health Medical Center Denver Colorado United States 80204
    71 Porter Adventist Hospital Denver Colorado United States 80210
    72 Colorado Blood Cancer Institute Denver Colorado United States 80218
    73 Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado United States 80218
    74 Rocky Mountain Cancer Centers-Midtown Denver Colorado United States 80218
    75 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    76 Rocky Mountain Cancer Centers-Rose Denver Colorado United States 80220
    77 Rose Medical Center Denver Colorado United States 80220
    78 Mercy Medical Center Durango Colorado United States 81301
    79 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    80 Swedish Medical Center Englewood Colorado United States 80113
    81 Mountain Blue Cancer Care Center Golden Colorado United States 80401
    82 Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado United States 81501
    83 North Colorado Medical Center Greeley Colorado United States 80631
    84 Rocky Mountain Cancer Centers-Greenwood Village Greenwood Village Colorado United States 80111
    85 Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado United States 80228
    86 Saint Anthony Hospital Lakewood Colorado United States 80228
    87 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
    88 Littleton Adventist Hospital Littleton Colorado United States 80122
    89 Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado United States 80124
    90 Sky Ridge Medical Center Lone Tree Colorado United States 80124
    91 Longmont United Hospital Longmont Colorado United States 80501
    92 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    93 McKee Medical Center Loveland Colorado United States 80539
    94 Parker Adventist Hospital Parker Colorado United States 80138
    95 Rocky Mountain Cancer Centers-Parker Parker Colorado United States 80138
    96 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    97 Rocky Mountain Cancer Centers-Thornton Thornton Colorado United States 80260
    98 SCL Health Lutheran Medical Center Wheat Ridge Colorado United States 80033
    99 Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut United States 06105
    100 Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut United States 06510
    101 Yale University New Haven Connecticut United States 06520
    102 Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut United States 06473
    103 University of Florida Health Science Center - Gainesville Gainesville Florida United States 32610
    104 Baptist MD Anderson Cancer Center Jacksonville Florida United States 32207
    105 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    106 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
    107 Kaiser Permanente Moanalua Medical Center Honolulu Hawaii United States 96819
    108 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    109 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    110 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    111 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    112 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    113 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    114 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    115 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    116 Illinois CancerCare-Canton Canton Illinois United States 61520
    117 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    118 Northwestern University Chicago Illinois United States 60611
    119 Rush University Medical Center Chicago Illinois United States 60612
    120 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    121 Carle on Vermilion Danville Illinois United States 61832
    122 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    123 Decatur Memorial Hospital Decatur Illinois United States 62526
    124 Carle Physician Group-Effingham Effingham Illinois United States 62401
    125 Crossroads Cancer Center Effingham Illinois United States 62401
    126 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    127 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    128 Northwestern Medicine Cancer Center Delnor Geneva Illinois United States 60134
    129 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    130 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    131 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    132 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    133 Loyola University Medical Center Maywood Illinois United States 60153
    134 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    135 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    136 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    137 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    138 Illinois CancerCare-Peru Peru Illinois United States 61354
    139 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    140 SwedishAmerican Regional Cancer Center/ACT Rockford Illinois United States 61114
    141 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    142 Springfield Clinic Springfield Illinois United States 62702
    143 Memorial Medical Center Springfield Illinois United States 62781
    144 Carle Cancer Center Urbana Illinois United States 61801
    145 The Carle Foundation Hospital Urbana Illinois United States 61801
    146 Northwestern Medicine Cancer Center Warrenville Warrenville Illinois United States 60555
    147 Parkview Hospital Randallia Fort Wayne Indiana United States 46805
    148 Parkview Regional Medical Center Fort Wayne Indiana United States 46845
    149 Reid Health Richmond Indiana United States 47374
    150 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    151 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    152 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    153 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    154 Broadlawns Medical Center Des Moines Iowa United States 50314
    155 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    156 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    157 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    158 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    159 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    160 Siouxland Regional Cancer Center Sioux City Iowa United States 51101
    161 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    162 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    163 Cancer Center of Kansas - Chanute Chanute Kansas United States 66720
    164 Cancer Center of Kansas - Dodge City Dodge City Kansas United States 67801
    165 Cancer Center of Kansas - El Dorado El Dorado Kansas United States 67042
    166 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    167 Cancer Center of Kansas-Independence Independence Kansas United States 67301
    168 Cancer Center of Kansas-Kingman Kingman Kansas United States 67068
    169 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    170 Cancer Center of Kansas-Liberal Liberal Kansas United States 67905
    171 Cancer Center of Kansas-Manhattan Manhattan Kansas United States 66502
    172 Cancer Center of Kansas - McPherson McPherson Kansas United States 67460
    173 Cancer Center of Kansas - Newton Newton Kansas United States 67114
    174 Cancer Center of Kansas - Parsons Parsons Kansas United States 67357
    175 Cancer Center of Kansas - Pratt Pratt Kansas United States 67124
    176 Cancer Center of Kansas - Salina Salina Kansas United States 67401
    177 Cancer Center of Kansas - Wellington Wellington Kansas United States 67152
    178 Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas United States 67208
    179 Cancer Center of Kansas - Wichita Wichita Kansas United States 67214
    180 Wesley Medical Center Wichita Kansas United States 67214
    181 Cancer Center of Kansas - Winfield Winfield Kansas United States 67156
    182 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    183 Jewish Hospital Louisville Kentucky United States 40202
    184 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    185 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    186 Baton Rouge General Medical Center Baton Rouge Louisiana United States 70806
    187 Hematology/Oncology Clinic PLLC Baton Rouge Louisiana United States 70809
    188 Tulane University Health Sciences Center New Orleans Louisiana United States 70112
    189 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    190 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    191 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    192 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    193 Bronson Battle Creek Battle Creek Michigan United States 49017
    194 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    195 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    196 Henry Ford Cancer Institute-Downriver Brownstown Michigan United States 48183
    197 Saint Joseph Mercy Canton Canton Michigan United States 48188
    198 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    199 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    200 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    201 Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan United States 48038
    202 Beaumont Hospital - Dearborn Dearborn Michigan United States 48124
    203 Henry Ford Medical Center-Fairlane Dearborn Michigan United States 48126
    204 Henry Ford Hospital Detroit Michigan United States 48202
    205 Ascension Saint John Hospital Detroit Michigan United States 48236
    206 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    207 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    208 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    209 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    210 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    211 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    212 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    213 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    214 Allegiance Health Jackson Michigan United States 49201
    215 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    216 Sparrow Hospital Lansing Michigan United States 48912
    217 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    218 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    219 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    220 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    221 Henry Ford Medical Center-Columbus Novi Michigan United States 48377
    222 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    223 Lake Huron Medical Center Port Huron Michigan United States 48060
    224 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    225 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    226 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    227 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    228 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    229 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    230 Munson Medical Center Traverse City Michigan United States 49684
    231 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    232 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    233 Macomb Hematology Oncology PC Warren Michigan United States 48093
    234 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    235 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    236 Henry Ford West Bloomfield Hospital West Bloomfield Michigan United States 48322
    237 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    238 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    239 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    240 Mercy Hospital Coon Rapids Minnesota United States 55433
    241 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    242 Essentia Health Cancer Center Duluth Minnesota United States 55805
    243 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    244 Miller-Dwan Hospital Duluth Minnesota United States 55805
    245 Fairview Southdale Hospital Edina Minnesota United States 55435
    246 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    247 Unity Hospital Fridley Minnesota United States 55432
    248 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    249 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    250 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    251 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    252 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    253 Health Partners Inc Minneapolis Minnesota United States 55454
    254 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    255 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    256 Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota United States 56303
    257 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    258 Regions Hospital Saint Paul Minnesota United States 55101
    259 United Hospital Saint Paul Minnesota United States 55102
    260 Essentia Health Sandstone Sandstone Minnesota United States 55072
    261 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    262 Lakeview Hospital Stillwater Minnesota United States 55082
    263 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    264 Ridgeview Medical Center Waconia Minnesota United States 55387
    265 Rice Memorial Hospital Willmar Minnesota United States 56201
    266 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    267 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    268 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    269 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    270 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    271 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    272 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    273 Saint Luke's Hospital of Kansas City Kansas City Missouri United States 64111
    274 Kansas City Veterans Affairs Medical Center Kansas City Missouri United States 64128
    275 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    276 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    277 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    278 Washington University School of Medicine Saint Louis Missouri United States 63110
    279 Mercy Hospital South Saint Louis Missouri United States 63128
    280 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    281 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    282 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    283 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    284 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    285 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    286 Mercy Hospital Springfield Springfield Missouri United States 65804
    287 CoxHealth South Hospital Springfield Missouri United States 65807
    288 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    289 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    290 Billings Clinic Cancer Center Billings Montana United States 59101
    291 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    292 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    293 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    294 Kalispell Regional Medical Center Kalispell Montana United States 59901
    295 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    296 Community Medical Hospital Missoula Montana United States 59804
    297 Nebraska Medicine-Bellevue Bellevue Nebraska United States 68123
    298 CHI Health Saint Francis Grand Island Nebraska United States 68803
    299 CHI Health Good Samaritan Kearney Nebraska United States 68847
    300 Nebraska Medicine-Village Pointe Omaha Nebraska United States 68118
    301 University of Nebraska Medical Center Omaha Nebraska United States 68198
    302 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    303 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    304 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    305 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    306 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    307 GenesisCare USA - Henderson Henderson Nevada United States 89074
    308 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    309 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    310 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    311 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    312 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    313 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    314 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    315 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    316 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    317 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    318 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    319 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    320 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    321 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    322 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    323 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    324 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    325 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    326 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    327 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    328 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    329 University Cancer Center Las Vegas Nevada United States 89169
    330 Renown Regional Medical Center Reno Nevada United States 89502
    331 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    332 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
    333 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    334 Roswell Park Cancer Institute Buffalo New York United States 14263
    335 Northwell Health/Center for Advanced Medicine Lake Success New York United States 11042
    336 North Shore University Hospital Manhasset New York United States 11030
    337 Long Island Jewish Medical Center New Hyde Park New York United States 11040
    338 NYP/Weill Cornell Medical Center New York New York United States 10065
    339 University of Rochester Rochester New York United States 14642
    340 Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina United States 28203
    341 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    342 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    343 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    344 Margaret R Pardee Memorial Hospital Hendersonville North Carolina United States 28791
    345 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    346 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    347 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    348 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    349 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    350 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    351 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    352 MetroHealth Medical Center Cleveland Ohio United States 44109
    353 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    354 Mount Carmel East Hospital Columbus Ohio United States 43213
    355 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    356 Riverside Methodist Hospital Columbus Ohio United States 43214
    357 The Mark H Zangmeister Center Columbus Ohio United States 43219
    358 Mount Carmel Health Center West Columbus Ohio United States 43222
    359 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    360 Miami Valley Hospital Dayton Ohio United States 45409
    361 Miami Valley Hospital North Dayton Ohio United States 45415
    362 Blanchard Valley Hospital Findlay Ohio United States 45840
    363 Saint Rita's Medical Center Lima Ohio United States 45801
    364 Marietta Memorial Hospital Marietta Ohio United States 45750
    365 Toledo Clinic Cancer Centers-Maumee Maumee Ohio United States 43537
    366 Licking Memorial Hospital Newark Ohio United States 43055
    367 Springfield Regional Cancer Center Springfield Ohio United States 45504
    368 Springfield Regional Medical Center Springfield Ohio United States 45505
    369 Toledo Clinic Cancer Centers-Toledo Toledo Ohio United States 43623
    370 Saint Ann's Hospital Westerville Ohio United States 43081
    371 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    372 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    373 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    374 Bay Area Hospital Coos Bay Oregon United States 97420
    375 Providence Newberg Medical Center Newberg Oregon United States 97132
    376 Providence Portland Medical Center Portland Oregon United States 97213
    377 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    378 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    379 Bryn Mawr Hospital Bryn Mawr Pennsylvania United States 19010
    380 Main Line Health Center-Collegeville Collegeville Pennsylvania United States 19426
    381 Geisinger Medical Center Danville Pennsylvania United States 17822
    382 Main Line Health Center-Exton Exton Pennsylvania United States 19341
    383 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    384 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    385 Riddle Memorial Hospital Media Pennsylvania United States 19063
    386 Paoli Memorial Hospital Paoli Pennsylvania United States 19301
    387 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    388 Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania United States 17870
    389 Reading Hospital West Reading Pennsylvania United States 19611
    390 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    391 Lankenau Medical Center Wynnewood Pennsylvania United States 19096
    392 Medical University of South Carolina Charleston South Carolina United States 29425
    393 Saint Francis Hospital Greenville South Carolina United States 29601
    394 Saint Francis Cancer Center Greenville South Carolina United States 29607
    395 Self Regional Healthcare Greenwood South Carolina United States 29646
    396 Spartanburg Medical Center Spartanburg South Carolina United States 29303
    397 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    398 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    399 M D Anderson Cancer Center Houston Texas United States 77030
    400 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    401 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    402 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    403 MultiCare Good Samaritan Hospital Puyallup Washington United States 98372
    404 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    405 Fred Hutchinson Cancer Research Center Seattle Washington United States 98109
    406 Seattle Cancer Care Alliance Seattle Washington United States 98109
    407 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    408 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    409 West Virginia University Charleston Division Charleston West Virginia United States 25304
    410 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    411 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    412 Marshfield Clinic-Chippewa Center Chippewa Falls Wisconsin United States 54729
    413 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    414 Marshfield Clinic - Ladysmith Center Ladysmith Wisconsin United States 54848
    415 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    416 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    417 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    418 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    419 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    420 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    421 Marshfield Clinic-Wausau Center Wausau Wisconsin United States 54401
    422 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    423 Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin United States 54494

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Paul M Barr, Southwest Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT03269669
    Other Study ID Numbers:
    • NCI-2017-00009
    • NCI-2017-00009
    • S1608
    • S1608
    • U10CA180888
    First Posted:
    Sep 1, 2017
    Last Update Posted:
    Aug 25, 2022
    Last Verified:
    Jun 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Aug 25, 2022