Haemodynamic Response to Aortic Surgery
Study Details
Study Description
Brief Summary
Open elective abdominal aortic surgery is a high risk procedure involving clamping of the aorta. Indications include abdominal aortic aneurysm (AAA) or aortic occlusive disease (AOD) causing lower limb ischaemia.
These patients are often regarded as one entity in postoperative study settings. However, previous studies indicate that risk profiles, inflammatory activity, and haemodynamic capacity may differ between these groups. The first aim of this study was to evaluate postoperative ICU-requirements after open elective abdominal aortic surgery, hypothesising that AAA-patients had longer ICU-stays and needed more mechanical ventilation or acute dialysis than did patients with AOD.
The investigators see a relatively high incidence of postoperative acute kidney injury (AKI) following aortic surgery. Neutrophil Gelatinase Associated Lipocalcin (NGAL) may be useful in the early diagnosis of postopeative AKI. However, NGAL is also known as a marker of inflammatory activation. The ischaemia-reperfusion injury and subsequent inflammatory response to aortic cross clamping may per se induce a rise in NGAL despite intact renal function. Therefore NGAL may not be a reliable marker of AKI after AAS.
The second aim of this study is to describe the changes in NGAL after AAS in patients with and without postoperative dialysis-dependent AKI.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Aortic aneurysm patients 10 patients with a CT verified diagnosis of aortic aneurysm demanding open elective surgical correction with insertion of vascular prosthesis |
|
| Aortic occlusive disease patients 10 patients with CT verified aortic occlusive disease demanding open elective surgical correction with insertion of vascular prosthesis |
Outcome Measures
Primary Outcome Measures
- ICU length of stay [24 hours postoperatively]
Number of patients with an ICU LOS > 24 hours
- Post-operative need for dialysis [72 hours postoperatively]
Number of patients developing dialysis dependency during the first 72 hours postoperatively
Secondary Outcome Measures
- Hemodynamic peroperative changes in AAD vs AOD [After anaesthesia induction, 10 minutes after aortic cross-clamping, 10 minutes after reperfusion, end of surgery]
Stroke volume, cardiac index, systemic vasular resistance is recorded for AAD- and AOD patients at five time points during the operation using CardioQ, an oesophagus doppler monitor.
Eligibility Criteria
Criteria
Inclusion Criteria:
- CT verified aortic aneurysm or aortic occlusive disease
Exclusion Criteria:
-
age<18 y
-
contraindications to the use of oesophagus doppler monitor, eg mycosis, perforation, stenosis.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Lillebaelt Hospital, Kolding Hospital | Kolding | Denmark | DK-6000 |
Sponsors and Collaborators
- Sygehus Lillebaelt
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- S-20110154