Platelet Rich Fibrin in Soft Tissue Healing After Implant Uncovering
Study Details
Study Description
Brief Summary
This study represents a prospective, controlled and randomized clinical trial assessing the effects of L-PRF on the healing time of the donor area and on the patient's postoperative morbidity in the 4 weeks following the Apically Positioned Flap (APF) procedure in the uncovering phase of two-stage implants.
A total of 40 patients were recruited and divided into two groups. The implant uncovering procedure in the test group was performed with APF and application of L-PRF on the donor area. Patients in the control group, on the other hand, were treated with APF alone, leaving the donor area to heal by secondary intention.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: APF + L-PRF Application of a layer of L-PRF to protect the donor area after uncovering implant procedure using Apically Positioned Flap (APF). |
Procedure: Application of L-PRF on the donor area
After implant uncovering procedure with apically positioned flap, the donor area is covered with a layer of L-PRF
|
Active Comparator: APF without L-PRF The donor area is left to heal by secondary intention after APF in the implant uncovering procedure. |
Procedure: Secondary intention healing of the donor area
After implant uncovering procedure with apically positioned flap, the donor area is left to heal by secondary intention
|
Outcome Measures
Primary Outcome Measures
- Complete re-epithelialization of the wound of donor area (CWE) [4 weeks]
Time needed to obtain a complete re-epithelialization of the wound of donor area
Secondary Outcome Measures
- Post-Operative Discomfort (D) [4 weeks]
Evaluation of post-operative discomfort using Visual Analogue Scale (VAS).The scale is represented by a straight horizontal line of fixed length, generally 10 cm. Extremities are defined as extreme limits of the parameter to be measured, oriented from left (worst) to right (best).
- Changes in Feedind Habits (CFH) [4 weeks]
Evaluation of changes in patients' feedind habits using Visual Analogue Scale (VAS).The scale is represented by a straight horizontal line of fixed length, generally 10 cm. Extremities are defined as extreme limits of the parameter to be measured, oriented from left (worst) to right (best).
- Consumption of Analgesics (AU) [4 weeks]
Assessment of postoperative pain by the number of analgesics taken
- Alteration of Sensivity (AS) [4 weeks]
Evaluation of alteration of sensivity on donor area
Eligibility Criteria
Criteria
Inclusion Criteria:
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to have at least one implant in the maxilla with a quantity of vestibular keratinized gingiva < 2 mm
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to be in good systemic health
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to have a good oral hygiene (FMPS and FMBS < 20%)
Exclusion Criteria:
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systemic diseases: coagulation disorders; medications affecting periodontal status in the previous 6 months; pregnancy or lactation;
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smoking habits;
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peri-implant surgery on the experimental sites.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | G. D'Annunzio University | Chieti | Italy | 66100 |
Sponsors and Collaborators
- G. d'Annunzio University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 19102021