Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance
Study Details
Study Description
Brief Summary
The primary objectives of the proposed experimental and modeling efforts are to quantify the influences of acute sleep deprivation (short-term homeostatic), chronic sleep restriction (long-term homeostatic), circadian rhythmicity, and their interactions on neurocognitive performance and to develop a new model of sleep homeostasis that can predict the effects of chronic sleep restriction. This model will be based on the underlying neuroanatomy and neurophysiology. This new model will facilitate optimization of human performance in operational settings, such as are seen in military operation and other work environments.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
This protocol involves a baseline period consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours. This is followed by a forced desynchrony regimen spanning 21 calendar days and consisting of 12 cycles ("days") of a 42.85-hour wake:bedrest schedule. In each 42.85 hour cycle, there are 32.85 hours of scheduled wakefulness and 10 hour sleep opportunities. This will allow assessment of the independent contributions of circadian phase and homeostatic sleep pressure on sleep and neurobehavioral performance. This forced desynchrony regimen is followed by 10 recovery days consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours.
Study Design
Outcome Measures
Primary Outcome Measures
- Sleep Stage [38 days]
- Circadian Phase (melatonin rhythm) [38 days]
- Psychomotor Vigilance Task [38 days]
- Digit Symbol Substitution Task [38 days]
- Addition Task [38 days]
- Karolinska Sleepiness Scale [38 days]
- Karolinska Drowsiness Test [38 days]
- Mood Scales [38 days]
- Flanker Task [38 days]
- Multiple Object Tracking [38 days]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 18-35 years old
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Medically healthy
Exclusion Criteria:
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Sleep disorder
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Psychiatric illness
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Chronic medical condition
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No prescription or Non-prescription medications
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Brigham and Woman's Hospital | Boston | Massachusetts | United States | 02115 |
Sponsors and Collaborators
- Brigham and Women's Hospital
Investigators
- Principal Investigator: Elizabeth B Klerman, M.D., Ph.D., Brigham and Woman's Hospital
- Principal Investigator: Charles A Czeisler, Ph.D., M.D., Brigham and Woman's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2200-100792