Diazepam and Blood Pressure Regulation
Study Details
Study Description
Brief Summary
The aim of this study is to determine the acute effects of diazepam on beat-to-beat blood pressure variability and baroreflex control.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
Early Phase 1 |
Detailed Description
Benzodiazepines are widely prescribed for a variety of clinical conditions. However, its cardiovascular consequences remain controversial. In this study, the investigators sought to determine the acute effects of a single dose of oral diazepam (10mg) on resting beat-to-beat blood pressure variability and cardiac and sympathetic baroreflex sensitivity in a cohort of young, healthy individuals.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Diazepam Oral |
Drug: Diazepam
Oral administration of 10 mg of diazepam
|
Placebo Comparator: Placebo Oral |
Drug: Diazepam
Oral administration of 10 mg of diazepam
|
Outcome Measures
Primary Outcome Measures
- Resting beat-to-beat blood pressure variability [Change from baseline at 60 min]
Finger photoplethysmography
- Systolic and diastolic blood pressure [Change from baseline at 60 min]
Oscillometric device
Secondary Outcome Measures
- Muscle sympathetic nerve activity [Change from baseline at 60 min]
Microneurography
- Baroreflex sensitivity [Change from baseline at 60 min]
The relationship between changes in beat-to-beat blood pressure and heart rate (cardiac baroreflex) or MSNA (sympathetic baroreflex).
Eligibility Criteria
Criteria
Inclusion Criteria:
-
18 to 40 years of age
-
Healthy, free of known cardiovascular, metabolic, or musculoskeletal disease
Exclusion Criteria:
-
History of smoking (tobacco or cannabis), defined as any smoking within the past 3 months
-
Diagnosed cardiovascular or metabolic disease(s)
-
Prescription of chronic medications other than oral contraceptives
-
History of hypertension or presence of arrhythmia
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Brasilia | BrasÃlia | DF | Brazil | 70910-900 |
Sponsors and Collaborators
- University of Brasilia
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 70101717.1.0000.5103