A Study in Healthy Men to Test Whether BI 425809 Influences the Amount of Midazolam in the Blood
Study Details
Study Description
Brief Summary
In order to assess the potential impact of steady state BI 425809 on CYP3A clinically, the effect of BI 425809 on the midazolam pharmacokinetics will be evaluated. Midazolam is a recommended substrate of CYP3A4.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 1 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Reference (R): midazolam alone First treatment period |
Drug: midazolam
midazolam
Other Names:
|
Experimental: Test (T): midazolam + BI 425809 Second treatment period |
Drug: midazolam
midazolam
Other Names:
Drug: BI 425809
BI 425809
|
Outcome Measures
Primary Outcome Measures
- Area under the concentration-time curve of midazolam in plasma over the time interval from 0 to the last quantifiable data point (AUC0-tz) [up to 12 hours per each period]
- Maximum measured concentration of midazolam in plasma (Cmax) [up to 12 hours per each period]
Secondary Outcome Measures
- Area under the concentration-time curve of midazolam in plasma over the time interval from 0 extrapolated to infinity (AUC0-∞) [up to 12 hours per each period]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Healthy male subjects according to the assessment of the investigator, as based on a complete medical history including a physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead electrocardiogram (ECG), and clinical laboratory tests
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Age of 18 to 55 years (inclusive)
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Body mass index (BMI) of 18.5 to 29.9 kg/m2 (inclusive)
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Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial
Exclusion Criteria:
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Any finding in the medical examination (including BP, PR or ECG) deviating from normal and assessed as clinically relevant by the investigator
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Repeated measurement of systolic blood pressure outside the range of 90 to 140 mmHg, diastolic blood pressure outside the range of 50 to 90 millimetre of mercury (mmHg), or pulse rate outside the range of 45 to 90 beats per minute (bpm)
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Any laboratory value outside the reference range that the investigator considers to be of clinical relevance
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Any evidence of a concomitant disease assessed as clinically relevant by the investigator
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Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders
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Cholecystectomy or other surgery of the gastrointestinal tract that could interfere with the pharmacokinetics of the trial medication (except appendectomy or simple hernia repair)
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Diseases of the central nervous system (including but not limited to any kind of seizures or stroke), and other relevant neurological or psychiatric disorders
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History of relevant orthostatic hypotension, fainting spells, or blackouts Further exclusion criteria apply
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Humanpharmakologisches Zentrum Biberach | Biberach | Germany | 88397 |
Sponsors and Collaborators
- Boehringer Ingelheim
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- 1346-0035
- 2021-005585-17