Dose-dependent Identification of Unique Biomarkers
Study Details
Study Description
Brief Summary
The purpose of the research is to assess the dose-dependent impacts of the consumption of fresh pork on blood-borne metabolites (markers) following the controlled feeding of pork
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
Eligible participants will follow 3 randomly ordered 4-week feeding periods varying only with the consumption of 0, 3 or 6 oz of pork or a 50:50 blend of chicken and beef (6, 3 and 0 oz for respective trials to ensure similar total poultry/meat intake among trials).
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: 0 oz Pork Participants receive 0 oz pork and 6 oz 50:50 blend of chicken and beef per day |
Dietary Supplement: Pork Consumption
Feeding of pork is controlled at 0, 3 or 6 oz per day for 4 weeks each in random order.
|
Experimental: 3 oz Pork Participants receive 3 oz pork and 3 oz 50:50 blend of chicken and beef per day |
Dietary Supplement: Pork Consumption
Feeding of pork is controlled at 0, 3 or 6 oz per day for 4 weeks each in random order.
|
Experimental: 6 oz Pork Participants receive 6 oz pork and 0 oz 50:50 blend of chicken and beef per day |
Dietary Supplement: Pork Consumption
Feeding of pork is controlled at 0, 3 or 6 oz per day for 4 weeks each in random order.
|
Outcome Measures
Primary Outcome Measures
- Metabolic biomarker discovery [4 weeks]
Biomolecules detected through metabolomic profiling that will result in discovery of a metabolic signature for pork intake
Secondary Outcome Measures
- Fasted Glucose [4 weeks]
- Insulin [4 weeks]
- HDL Cholesterol [4 weeks]
- Total Cholesterol [4 weeks]
- LDL-Cholesterol [4 weeks]
- Triglycerides [4 weeks]
- Interleukin-6 [4 weeks]
- C-Reactive Protein [4 weeks]
- Blood Pressure [4 weeks]
Systolic and Diastolic
- Body Composition [4 weeks]
Weight measured via scalre, body fat% muscle mass as measured via DEXA
Eligibility Criteria
Criteria
Inclusion Criteria:
-
generally healthy (i.e., an absence of diagnosed chronic illnesses and inborn metabolic disorders)
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Age 18-65
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all races
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both sexes
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willingness to comply with the research diet requirements
Exclusion Criteria:
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special dietary needs (e.g., vegetarianism, gluten-free, etc.)
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use of medication known to influence metabolism
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smoking
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substance use
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- San Diego State University
Investigators
- Principal Investigator: Shirin Hooshmand, PhD, San Diego State University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 5A949A