PROSCEA: Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults
Study Details
Study Description
Brief Summary
It is now widely accepted that autism is linked to a developmental disorder and cerebral function.
Our research team (UMR U930 INSERM, François-Rabelais University of Tours, whom Pr F Bonnet-Brilhault is responsible for team "Autism") hypothesizes that atypical sensory information processing, especially auditory and / or visual information, could underly the symptoms observed in autism. A better knowledge of the typical development of the sensory and cognitive processes must therefore make it possible in the long term to identify the abnormalities linked to the autism spectrum disorders (ASD).
Studies in healthy subjects are therefore necessary in order to identify neurophysiological indices of cerebral functioning and to study their evolution during normal development, making it possible in the future to compare with populations of subjects with ASD.
The investigators intend to study the development of all the cognitive processes involved in the processing of sensory and, in particular, auditory and visual information in humans: from low-level perception processes to higher-level cognitive processes (attention, emotion, language, prediction, ...). For this the investigators will use non-invasive neurophysiological explorations (EEG, eye tracking) as well as neuropsychological explorations (Questionnaires or spontaneous language recording).
A better understanding of the pathophysiological mechanisms underlying the symptoms observed in autism could ultimately lead to the development of new specific therapeutic strategies, particularly in the field of exchange and development therapy or cognitive remediation .
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Healthy volunteer Neurophysiological assessment Neuropsychological assessment |
Behavioral: Neurophysiological assessment
Assessment of cerebral electrical activity Assessment of ocular exploration Neurovegetative assessments
Behavioral: Neuropsychological assessment
sub-tests, scales, surveys, reaction time measurement
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Outcome Measures
Primary Outcome Measures
- ERP amplitude (µV) [1 hour]
analysis of ERP amplitude evoked during EEG recording
Secondary Outcome Measures
- Reaction times (ms) [1 hour]
Reaction times collected during behavioral assessment
- pupil size (mm) [1 hour]
pupil size measurements acquired with the eye tracker
Eligibility Criteria
Criteria
Inclusion Criteria:
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Between 1 and 60 years-old
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Able to understand and apply instructions for a task
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Information of subject or legal representant
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Informed written consent of subject or legal representant
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Affiliation to the social security system
Exclusion Criteria:
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Abnormal corrected vision
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Abnormal audition
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Known personal neurological pathology
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Known personal psychiatric problems
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Identified difficulties for walking, language, or learning
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Exclusion period because of participation to another experimental protocol
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Adult with legal protection
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Chru Tours | Tours | France | 37044 |
Sponsors and Collaborators
- University Hospital, Tours
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PHAO17-FBB/PROSCEA