InoBAT: Inosine Energy Expenditure Study
Investigators want to test whether the intake of the nucleoside inosine increases the human energy expenditure. Inosine occurs as a metabolic intermediate in the human body and is sometimes taken as a dietary supplement by athletes.
For this purpose, investigators will measure the basal metabolic rate by indirect calorimetry. Study participants will then take inosine dissolved in water or placebo and energy expenditure will be assessed again.
|Condition or Disease||Intervention/Treatment||Phase|
Arms and Interventions
2 grams of inosine dissolved in 250 ml of tap water
Dietary Supplement: Inosine
2 grams of inosine dissolved in 250 ml water taken by mouth
|Placebo Comparator: Water|
250 ml of tap water only
250 ml water taken by mouth
Primary Outcome Measures
- resting energy expenditure after Inosine [one hour after oral intake of inosine]
resting energy expenditure (REE) assessed by indirect calorimetry after oral intake of two grams of inosine as compared to placebo
Secondary Outcome Measures
- Change in energy expenditure [one hour after oral intake of inosine]
- Difference in EE between baseline measurement and measurement one hour after administration of inosine or control, respectively, at each study visit.
- Change in Respiratory Quotient [one hour after oral intake of inosine]
- Respiratory quotient (RQ) as an indicator of substrate oxidation one hour after oral intake of two grams of inosine
- Serum inosine level [0 hours, 1 hour, 2 hours]
Serum inosine levels after ingestion of inosine
Healthy male volunteers
BMI between 18-27 kg/m2
Age between 18 and 40 years
Chronic concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),
Known or suspected non-compliance, drug or alcohol abuse,
Inability to follow the procedures of the study
Participation in another study with investigational drug within the 30 days preceding and during the present study,
Previous enrolment into the current study,
Enrolment of the investigator, his/her family members, employees and other dependent persons,
Contacts and Locations
LocationsNo locations specified.
Sponsors and Collaborators
- University Hospital, Basel, Switzerland
Study Documents (Full-Text)None provided.