The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery
Study Details
Study Description
Brief Summary
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography. Investigators hypothesize that induced mild hypercarbia (PaCO2 7.5 kPa) cause elevated mean pulmonary arterial pressure and pulmonary vascular resistance, and this reflect to the right ventricle, both volume and function. And this right ventricle effect could be noticed by echocardiography.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Hypercarbia Hypercarbia: PaCO2 is elevated from 5 to 7.5 kPa by controlled ventilation. |
Procedure: Hypercarbia
PaCO2 is elevated from 5 to 7.5 kPa by controlled ventilation.
|
Outcome Measures
Primary Outcome Measures
- Tricuspid annular plane systolic excursion (TAPSE) [Change from baseline TAPSE at hypercarbia (in approximately 30 min)]
TAPSE will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa)
- Mean pulmonary artery pressure (MPAP) [Change from baseline MPAP at hypercarbia (in approximately 30 min)]
MPAP will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa)
Eligibility Criteria
Criteria
Inclusion Criteria:
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scheduled mitral valve prolapse repair surgery
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able to give informed consent
Exclusion Criteria:
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preoperative right ventricular dysfunction or pulmonary hypertension
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significant tricuspid regurgitation
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congenital heart defect
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ventricular dyssynchrony or wide QRS-complex on ECG (> 130 ms)
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prior myocardial infarction (within tree months) or pericardial constriction
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preoperative left ventricular (LV) dysfunction, i.e. LV ejection fraction under 40 %
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if the scheduled repair by plastic procedure has been converted to mitral valve replacement
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Tampere University Hospital Heart Center | Tampere | Finland | 33521 |
Sponsors and Collaborators
- Tampere University Hospital
Investigators
- Principal Investigator: Kati Järvelä, MD, Tampere University Hospital
- Principal Investigator: Kati Rautaneva, MD, Tampere University Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- R16005