Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD
Study Details
Study Description
Brief Summary
INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding of the same situations, with which the clinical profile of patients who are associated with an association is. It is known that regular physical training promotes progressive improvements in exercise tolerance, in the pulmonary ventilation / perfusion ratio and in respiratory function by strengthening. OBJECTIVE: To compare the effects of high-intensity interval training and continuous aerobic exercise, with peripheral endothelial function, brain natriuretic peptide levels, maximum exercise tolerance, distribution of lung volumes and quality of life of patients with obstructive pulmonary disease associated with heart failure. METHODS: This is a clinical, controlled, randomized and blinded trial. Peripheral endothelial function, tolerance to maximum and submaximal exercise, distribution of lung volumes, quality of life, presence of symptoms of depression and perception of clinical change will be evaluated. EXPECTED RESULTS: Incorporate into the care of these patients, new effective therapeutic approaches, of low cost and with greater technical and scientific evidence.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Interval training Interval training will consist of 10 minutes of warm-up between 40-50% of the peak oxygen consumption (VO2peak), followed by four to six repetitions of three-minute intervals between 80-90% of VO2peak and three minutes between 40-50% VO2peak and finally, five minutes of cooling down between 30-40% of VO2peak. |
Other: High-intensity interval training
Exercise with high-intensity intervals followed by active rest
|
Active Comparator: Continuous training The continuous aerobic training will consist of 10 minutes of warm-up with intensity between 40 and 50% of VO2peak, 20 minutes of conditioning between 60 and 70% of VO2peak and 5 minutes of cooling down between 30 and 40% of VO2peak. |
Other: Continuous aerobic training
Interval Moderate-intensity aerobic training without intervals
|
Outcome Measures
Primary Outcome Measures
- Exercise tolerance [24 weeks]
Evaluated by the cardiopulmonary exercise test by measuring the maximum oxygen consumption.
- Peripheral endothelial function [24 weeks]
Evaluated by the peripheral arterial tonometry using the EndoPat 2000 device
Secondary Outcome Measures
- Quality of life assessment: Short Form-36 questionnaire [24 weeks]
Evaluated by the Short Form-36 questionnaire
- Perception of clinical change [24 weeks]
Evaluated by the Patient Global Impression of Change Scale which is a one-dimensional measure in which individuals can rate their associated improvement on a 7-item scale ranging from "1 = no changes" to "7 = much better".
- Distance covered in the six-minute walk test [24 weeks]
Evaluated by the six-minute walk test
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Sedentary individuals with Heart Failure of all etiologies;
-
Diagnosed moderate and severe chronic obstructive pulmonary disease;
-
Clinical stability;
-
No change in the medication class within three months before the beginning of the research.
Exclusion Criteria:
-
Unstable angina;
-
Myocardial infarction;
-
Previous cardiac surgery up to three months before the beginning of the study;
-
Hemodynamic instability;
-
Orthopedic and neurological diseases;
-
Psychological and/or mental impairment.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Federal University of Pernambuco | Recife | Pernambuco | Brazil | 50740-560 |
Sponsors and Collaborators
- Universidade Federal de Pernambuco
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 07640919.4.0000.5208