FINEARTS-HF: Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%
Sponsor
Bayer (Industry)
Overall Status
Recruiting
CT.gov ID
NCT04435626
Collaborator
(none)
6,000
739
2
48
8.1
0.2
Study Details
Study Description
Brief Summary
The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 5500 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
6000 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%)
Actual Study Start Date
:
Sep 14, 2020
Anticipated Primary Completion Date
:
Aug 9, 2024
Anticipated Study Completion Date
:
Sep 13, 2024
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm 1_BAY94-8862 Adult patients receive BAY94-8862 |
Drug: Finerenone (BAY94-8862)
For participants with an eGFR ≤60 mL/min/1.73 m^2: Starting dose is 10 mg OD and maximum dose 20 mg OD.
For participants with an eGFR >60 mL/min/1.73 m^2: Starting dose is 20 mg OD and maximum dose 40 mg OD. Finerenone is administered orally as immediate release tablets.
|
| Placebo Comparator: Arm 2_Placebo Adult patients receive placebo |
Other: Placebo
Placebo tablets matching BAY94-8862 are administered orally.
|
Outcome Measures
Primary Outcome Measures
- Number of cardiovascular deaths and heart failure events [Up to 42 months]
Composite endpoint. Heart Failure events comprise first and recurrent events
Secondary Outcome Measures
- Time to total (first and recurrent) HF events [Up to 42 months]
- Improvement in NYHA class from Baseline to Month 12 [Up to 12 month after start of treatment]
- Change in Total Symptom Score (TSS) from KCCQ. [At baseline, Months 6, 9 and 12]
Patient Reported Outcomes measured by Kansas City Cardiomyopathy Questionnaire (KCCQ)
- Time to first occurrence of composite renal endpoint [Up to 42 months]
Composite renal endpoint: sustained decrease in estimated glomerular filtration rate (eGFR) ≥50% relative to baseline over at least 4 weeks, or sustained eGFR decline to <15ml/min/1.73m2 or initiation of dialysis or renal transplantation.
- Time to death from any cause [Up to 42 months]
Eligibility Criteria
Criteria
Ages Eligible for Study:
40 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Participant (male or female) must be aged 40 years and older.
-
Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.
-
On diuretic treatment for at least 30 days prior to randomization.
-
Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.
-
Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) >30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm
-
n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:
-
Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
-
Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.
-
Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.
Exclusion Criteria:
-
Estimated glomerular filtration rate (eGFR) <25 mL/min/1.73 m² at either screening or randomization visit.
-
Serum/plasma potassium >5.0 mmol/L at either screening or randomization visit.
-
Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
-
Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
-
Coronary artery bypass graft surgery in the 90 days prior to randomization
-
Percutaneous coronary intervention in the 30 days prior to randomization
-
Stroke or transient ischemic cerebral attack within 90 days prior to randomization
-
Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin <10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) >50 kg/m2 at screening
-
Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
-
Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cardiology, PC | Birmingham | Alabama | United States | 35211 |
| 2 | Heart Group of the Eastern Shore | Fairhope | Alabama | United States | 36532 |
| 3 | Mobile Heart Specialists, PC | Mobile | Alabama | United States | 36608 |
| 4 | University of Arizona Health Science Center | Tucson | Arizona | United States | 85724 |
| 5 | Heart Clinic Arkansas | Little Rock | Arkansas | United States | 72205 |
| 6 | Cardiology Consultants of Orange County | Anaheim | California | United States | 92801 |
| 7 | WestSide Medical | Beverly Hills | California | United States | 90211 |
| 8 | California Heart Specialists | Huntington Beach | California | United States | 92648 |
| 9 | Univ. of California San Diego - La Jolla | La Jolla | California | United States | 92037 |
| 10 | UC Irvine Medical Center | Orange | California | United States | 92868 |
| 11 | Sutter Heart & Vascular Institute | Sacramento | California | United States | 95816 |
| 12 | San Diego VA Medical Center | San Diego | California | United States | 92161 |
| 13 | North Bay Cardiology, Inc. | Santa Rosa | California | United States | 95405 |
| 14 | Harbor - UCLA Medical Center | Torrance | California | United States | 90502 |
| 15 | Blue Coast Research Center, LLC | Vista | California | United States | 92083 |
| 16 | Interventional Cardio Medical- DCT Department | West Hills | California | United States | 91307 |
| 17 | Interventional Cardiology Medical Group | West Hills | California | United States | 91307 |
| 18 | VA Eastern Colorado Health Care System | Aurora | Colorado | United States | 80045 |
| 19 | Colorado Springs Cardiology | Colorado Springs | Colorado | United States | 80923 |
| 20 | South Denver Cardiology Associates, PC | Littleton | Colorado | United States | 80120 |
| 21 | Cardiovascular and Vein Center of Florida | Bradenton | Florida | United States | 34209 |
| 22 | Nova Clinical Research, LLC | Bradenton | Florida | United States | 34209 |
| 23 | Cardiology Associates Research Company | Daytona Beach | Florida | United States | 32117 |
| 24 | Malcom Randall VA Medical Ctr | Gainesville | Florida | United States | 32608 |
| 25 | LifeSpring Research Foundation, LLC | Miami | Florida | United States | 33130 |
| 26 | Southwest Florida Research | Naples | Florida | United States | 34102 |
| 27 | East Coast Institute for Research, LLC - St Augustine | Saint Augustine | Florida | United States | 32086 |
| 28 | Tallahassee Research Institute | Tallahassee | Florida | United States | 32308 |
| 29 | Cardiology Partners | Wellington | Florida | United States | 33449 |
| 30 | IACT Health | Columbus | Georgia | United States | 31904 |
| 31 | Atlanta Heart Specialists, LLC | Tucker | Georgia | United States | 30084 |
| 32 | Advocate Illinois Masonic Medical Center | Chicago | Illinois | United States | 60657 |
| 33 | Advocate Good Samaritan Hospital | Downers Grove | Illinois | United States | 60515 |
| 34 | Advocate Condell Medical Center | Libertyville | Illinois | United States | 60048 |
| 35 | Edward Hospital-Main Campus | Naperville | Illinois | United States | 60540 |
| 36 | Captain James A. Lovell Federal Health Care Center | North Chicago | Illinois | United States | 60064 |
| 37 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61606 |
| 38 | Midwest Cardiovascular Research and Education Foundation | Elkhart | Indiana | United States | 46514 |
| 39 | Reid Health | Richmond | Indiana | United States | 47374 |
| 40 | University of Iowa Hospitals & Clinics | Iowa City | Iowa | United States | 52242 |
| 41 | Kansas Nephrology Research Institute, LLC | Wichita | Kansas | United States | 67214 |
| 42 | Baptist Health Paducah | Paducah | Kentucky | United States | 42003 |
| 43 | Cardiovascular Associates Research, LLC | Covington | Louisiana | United States | 70433 |
| 44 | Heart Clinic of Hammond | Hammond | Louisiana | United States | 70403 |
| 45 | Louisiana Heart Center Research - Slidell | Slidell | Louisiana | United States | 70458 |
| 46 | Southern Clinical Research, LLC | Zachary | Louisiana | United States | 70791 |
| 47 | Maine Medical Partners-Maine Health Cardiology | Scarborough | Maine | United States | 04074 |
| 48 | Maryland Cardiovascular Specialists | Baltimore | Maryland | United States | 21229 |
| 49 | John Hopkins Outpatient Center | Baltimore | Maryland | United States | 21287 |
| 50 | Suburban Hospital | Bethesda | Maryland | United States | 20814 |
| 51 | Cardiovascular Specialists of Central Maryland, PA | Columbia | Maryland | United States | 21044 |
| 52 | Henry Ford Health System | Detroit | Michigan | United States | 48202 |
| 53 | Aa Mrc, Llc | Flint | Michigan | United States | 48504 |
| 54 | Western Michigan University School of Medicine | Kalamazoo | Michigan | United States | 49007 |
| 55 | M Health Fairview | Maplewood | Minnesota | United States | 55109 |
| 56 | Minneapolis VA Medical Center | Minneapolis | Minnesota | United States | 55417 |
| 57 | M Health Fairview Heart Clinic - Fulton | Minneapolis | Minnesota | United States | 55455 |
| 58 | St. Cloud Hospital | Saint Cloud | Minnesota | United States | 56303 |
| 59 | Baptist Heart -Cardiology - DCT Dept | Jackson | Mississippi | United States | 39202 |
| 60 | Baptist Heart -Cardiology - Main | Jackson | Mississippi | United States | 39202 |
| 61 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216-4505 |
| 62 | Harry S. Truman Memorial Veterans Hospital | Columbia | Missouri | United States | 65201 |
| 63 | Clinical Research Consultants | Kansas City | Missouri | United States | 64111 |
| 64 | St. Luke's Mid America Heart Institute | Kansas City | Missouri | United States | 64111 |
| 65 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 66 | Logan Health Research | Kalispell | Montana | United States | 59901 |
| 67 | Nebraska Heart Institute- Grand Island | Grand Island | Nebraska | United States | 68803 |
| 68 | CHI Health Nebraska Heart | Lincoln | Nebraska | United States | 68526 |
| 69 | Advanced Heartcare, LLC | Bridgewater | New Jersey | United States | 08807 |
| 70 | NJ Medcare/NJ Heart | Linden | New Jersey | United States | 07036 |
| 71 | Garden State Heart Care | Manalapan | New Jersey | United States | 07726 |
| 72 | Cardiac Care & Vascular Medicine | Bronx | New York | United States | 10469 |
| 73 | New York Methodist Hospital | Brooklyn | New York | United States | 11215 |
| 74 | Mount Sinai West Hospital | New York | New York | United States | 10019 |
| 75 | Hudson Valley Cardiovascular Practice, PC | Poughkeepsie | New York | United States | 12601 |
| 76 | Division of Cardiovascular Research at Peconic Bay Med Ctr | Riverhead | New York | United States | 11901 |
| 77 | Laurelton Heart Specialists | Rosedale | New York | United States | 11422 |
| 78 | Saratoga Clinical Research, LLC | Saratoga Springs | New York | United States | 12866 |
| 79 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 80 | Northwell Health Phys. Partners Cardiology at Valley Stream | Valley Stream | New York | United States | 11580 |
| 81 | Kernodle Clinic West, Private Diagnostic Clinic PLLC | Burlington | North Carolina | United States | 27215 |
| 82 | University of North Carolina | Chapel Hill | North Carolina | United States | 27599 |
| 83 | Wake Forest Baptist Health | Winston-Salem | North Carolina | United States | 27157-1082 |
| 84 | TriHealth Good Samaritan Hospital | Cincinnati | Ohio | United States | 45220 |
| 85 | Kettering Health Network | Kettering | Ohio | United States | 45429 |
| 86 | Rama Research, LLC | Marion | Ohio | United States | 43302 |
| 87 | Mercy Health - St. Elizabeth Youngstown Hospital | Youngstown | Ohio | United States | 44501 |
| 88 | South Oklahoma Heart Research, LLC | Oklahoma City | Oklahoma | United States | 73135 |
| 89 | Capital Area Research, LLC | Camp Hill | Pennsylvania | United States | 17011 |
| 90 | Doylestown Cardiology Associates-VIAA | Doylestown | Pennsylvania | United States | 18901 |
| 91 | Kent Hospital | Warwick | Rhode Island | United States | 02886 |
| 92 | Trident Cardiology Associates, PA | Ladson | South Carolina | United States | 29456 |
| 93 | Carolina Heart Specialists | Lancaster | South Carolina | United States | 29720 |
| 94 | PMG Research of Charleston | Mount Pleasant | South Carolina | United States | 29464 |
| 95 | Monument Health Clinical Research | Rapid City | South Dakota | United States | 57701 |
| 96 | Sanford USD Medical Center | Sioux Falls | South Dakota | United States | 57105 |
| 97 | The Stern Cardiovascular Foundation, Inc. | Germantown | Tennessee | United States | 38138 |
| 98 | Apex Cardiology, LLC | Jackson | Tennessee | United States | 38301 |
| 99 | Memphis VA Medical Center | Memphis | Tennessee | United States | 38104 |
| 100 | Cardiovascular Research of Knoxville | Powell | Tennessee | United States | 37849 |
| 101 | Seton Heart Institute | Austin | Texas | United States | 78705 |
| 102 | Texas Health Physicians Group - Dallas | Dallas | Texas | United States | 75231 |
| 103 | Southwest Family Medicine Associates | Dallas | Texas | United States | 75235 |
| 104 | Texas Health Physicians Group - Fort Worth | Fort Worth | Texas | United States | 76107 |
| 105 | University of Texas Medical Branch at Galveston | Galveston | Texas | United States | 77555-0553 |
| 106 | Houston Heart & Vascular Associates | Humble | Texas | United States | 77338 |
| 107 | South Texas Cardiovascular Consultants, PLLC / Kerrville, TX | Kerrville | Texas | United States | 78028 |
| 108 | North Dallas Research Associates | McKinney | Texas | United States | 75069 |
| 109 | ClinRx Research, LLC | Plano | Texas | United States | 75024 |
| 110 | South Texas Cardiovascular Consultants, PLLC /San Antonio,TX | San Antonio | Texas | United States | 78201 |
| 111 | Clinical Advancement Center, PLLC | San Antonio | Texas | United States | 78212-4740 |
| 112 | Northwest Houston Heart Center | Tomball | Texas | United States | 77375 |
| 113 | University of Utah Health Care | Salt Lake City | Utah | United States | 84132 |
| 114 | Inova Medical Group - Mt. Vernon | Alexandria | Virginia | United States | 22306 |
| 115 | IMG Cardiology- Fairfax | Fairfax | Virginia | United States | 22031 |
| 116 | Virginia Heart | Falls Church | Virginia | United States | 22042 |
| 117 | Virginia Heart | Leesburg | Virginia | United States | 20176 |
| 118 | Sentara Norfolk General Hospital | Norfolk | Virginia | United States | 23507 |
| 119 | Hunter Holmes McGuire Veterans Affairs Medical Center | Richmond | Virginia | United States | 23249 |
| 120 | Salem VA Medical Center | Salem | Virginia | United States | 24153 |
| 121 | Selma Medical Associates | Winchester | Virginia | United States | 22601 |
| 122 | WVU Heart & Vascular Institute | Morgantown | West Virginia | United States | 26506 |
| 123 | William S. Middleton Memorial Veterans Hospital | Madison | Wisconsin | United States | 53705 |
| 124 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 125 | Aspirus Research Institute | Wausau | Wisconsin | United States | 54401 |
| 126 | IMOBA Investigaciones Clinicas | Caba | Buenos Aires | Argentina | C1179AAB |
| 127 | Clínica Coronel Suarez | Coronel Suarez | Buenos Aires | Argentina | B7540GHD |
| 128 | Hospital Italiano de la Plata | La Plata | Buenos Aires | Argentina | 1900 |
| 129 | Centro de Investigación Médica Lanús | Lanús | Buenos Aires | Argentina | B1824KAJ |
| 130 | Sanatorio Modelo Quilmes | Quilmes | Buenos Aires | Argentina | |
| 131 | Corporación Médica de General San Martín | San Martín | Buenos Aires | Argentina | 1650 |
| 132 | Instituto de Investigaciones Clínicas Zárate | Zárate | Buenos Aires | Argentina | B2800DGH |
| 133 | Hospital Militar Central "CIR. MY. C. Argerich" | Buenos Aires | Ciudad Auton. De Buenos Aires | Argentina | 1426 |
| 134 | Centro de Investigaciones Metabólicas | Buenos Aires | Ciudad Auton. De Buenos Aires | Argentina | C1056ABJ |
| 135 | Instituto Cardiovascular de Buenos Aires | Buenos Aires | Ciudad Auton. De Buenos Aires | Argentina | C1428ART |
| 136 | Centro de Investigaciones Clínicas | Caba | Ciudad Auton. De Buenos Aires | Argentina | C1018DES |
| 137 | Centro de Especialidades Médicas | Villa Luro | Ciudad Auton. De Buenos Aires | Argentina | C1440CFD |
| 138 | Instituto Cardiovascular | Rosario | Santa Fe | Argentina | 2000 |
| 139 | Instituto Médico de la Fundación Estudios Clinicos | Rosario | Santa Fe | Argentina | S2000DEJ |
| 140 | Instituto de Cardiología | San Miguel de Tucuman | Tucuman | Argentina | 4000 |
| 141 | Inst. de Cardiología de Corrientes Juana Francisca Cabral | Corrientes | Argentina | 3400 | |
| 142 | Clínica Privada del Prado | Córdoba | Argentina | X5000AAX | |
| 143 | Instituto Médico DAMIC- Fundación Rusculleda | Córdoba | Argentina | X5003DCE | |
| 144 | Centro de Investigaciones Clinicas del Litoral | Santa Fe | Argentina | S3000FWO | |
| 145 | Royal Prince Alfred Hospital | Camperdown | New South Wales | Australia | 2050 |
| 146 | Gosford Hospital | Gosford | New South Wales | Australia | 2250 |
| 147 | John Hunter Hospital | New Lambton Heights | New South Wales | Australia | 2305 |
| 148 | The Wesley Hospital | Auchenflower | Queensland | Australia | 4066 |
| 149 | Royal Brisbane and Women's Hospital | Brisbane | Queensland | Australia | 4029 |
| 150 | Gold Coast University Hospital | Gold Coast | Queensland | Australia | 4215 |
| 151 | Flinders Medical Centre | Adelaide | South Australia | Australia | 5042 |
| 152 | GenesisCare Leabrook | Leabrook | South Australia | Australia | 5068 |
| 153 | GenesisCare Ringwood | Bundoora | Victoria | Australia | 3083 |
| 154 | The Prince Charles Hospital | Chermside | Australia | 4032 | |
| 155 | Klinikum Klagenfurt am Wörthersee | Klagenfurt | Kärnten | Austria | 9020 |
| 156 | Universitätsklinikum St. Pölten | St. Pölten | Niederösterreich | Austria | 3100 |
| 157 | Krankenhaus St. Josef Braunau | Braunau | Oberösterreich | Austria | 5280 |
| 158 | Medizinische Universität Graz | Graz | Steiermark | Austria | 8036 |
| 159 | Landeskrankenhaus Feldkirch | Feldkirch | Vorarlberg | Austria | 6807 |
| 160 | Uniklinikum Salzburg - Landeskrankenhaus | Salzburg | Austria | 5020 | |
| 161 | Universitätsklinikum AKH Wien | Wien | Austria | 1090 | |
| 162 | Imed19-privat | Wien | Austria | 1190 | |
| 163 | Klinik Floridsdorf - Krankenhaus Nord | Wien | Austria | 1210 | |
| 164 | Santa Casa de Misericórdia da Bahia | Salvador | Bahia | Brazil | 40050-410 |
| 165 | Hospital do Coração do Brasil | Brasília | Distrito Federal | Brazil | 70390-700 |
| 166 | Hospital das Clínicas de Goiânia | Goiânia | Goiás | Brazil | 74605-020 |
| 167 | Eurolatino Pesquisas Médicas Ltda. | Uberlândia | Minas Gerais | Brazil | 38411-186 |
| 168 | Núcleo de Pesquisa Clínica do Hospital Angelina Caron | Campina Grande do Sul | Parana | Brazil | 83430 000 |
| 169 | QUANTA Diagnósticos e Terapia | Curitiba | Parana | Brazil | 80045-170 |
| 170 | Fundação Universidade de Caxias do Sul | Caxias do Sul | Rio Grande Do Sul | Brazil | 95070-560 |
| 171 | Hospital de Clínicas de Porto Alegre | Porto Alegre | Rio Grande Do Sul | Brazil | 90035-007 |
| 172 | Hospital Mae de Deus | Porto Alegre | Rio Grande Do Sul | Brazil | 90110-000 |
| 173 | Hospital Nossa Senhora da Conceição | Porto Alegre | Rio Grande Do Sul | Brazil | 91350-200 |
| 174 | MK Consultoria Médico Científica Ltda/Angiocor Blumenau | Blumenau | Santa Catarina | Brazil | 89020-430 |
| 175 | Hospital Felício Rocho | Belo Horizonte | Sao Paulo | Brazil | 30110-130 |
| 176 | Inst. Pesq. Clínica de Campinas - Saraiva & Berlinger | Campinas | Sao Paulo | Brazil | 13060-080 |
| 177 | ICM - Instituto do Coração de Marília | Marília | Sao Paulo | Brazil | 17515-000 |
| 178 | Centro Avançado de Pesquisa para Diagnóstico - CAPED | Ribeirão Preto | Sao Paulo | Brazil | 14026-020 |
| 179 | IMC - Instituto de Moléstias Cardiovasculares Tatui | Tatui | Sao Paulo | Brazil | 18270-170 |
| 180 | Santa Casa de Misericórdia de Votuporanga | Votuporanga | Sao Paulo | Brazil | |
| 181 | Clínica do Coração | Aracajú | Sergipe | Brazil | 49055-530 |
| 182 | PUC Campinas | Campinas | Brazil | 13060-803 | |
| 183 | Instituto Brasil de Pesquisa Clínica S/A - IBPClin | Rio de Janeiro | Brazil | 20241-180 | |
| 184 | Ambulatory facility for specialized outpatient medical care | Burgas | Bulgaria | 8000 | |
| 185 | MHAT Haskovo | Haskovo | Bulgaria | 6300 | |
| 186 | MHAT Zdrave | Pazardjik | Bulgaria | 4400 | |
| 187 | Spec Hosp for Active Treatm in Cardiology Sv Georgi Pernik | Pernik | Bulgaria | 2300 | |
| 188 | Medical Center Medconsult Pleven | Pleven | Bulgaria | 5800 | |
| 189 | Medical centre Hipokrat - N EOOD | Plovdiv | Bulgaria | 4000 | |
| 190 | Multiprofile Hospital for Active Treatment Medline Clinic | Plovdiv | Bulgaria | 4000 | |
| 191 | MHAT Sveta Karidad | Plovdiv | Bulgaria | 4004 | |
| 192 | MHAT Shumen AD | Shumen | Bulgaria | 9700 | |
| 193 | MHAT Hadzhi Dimitar | Sliven | Bulgaria | 8800 | |
| 194 | Second Medical Center Sofia EOOD | Sofia | Bulgaria | 1202 | |
| 195 | MHAT "Knyaginya Klementina - Sofia"EAD | Sofia | Bulgaria | 1233 | |
| 196 | NMTH Tzar Boris III | Sofia | Bulgaria | 1233 | |
| 197 | MHAT National Cardiology Hospital EAD | Sofia | Bulgaria | 1309 | |
| 198 | Medical Center Hera | Sofia | Bulgaria | 1510 | |
| 199 | UMHAT Tsaritsa Joanna-ISUL EAD Sofia | Sofia | Bulgaria | 1527 | |
| 200 | Multiprofile Hospital for Active Treatment Sveta Sofia | Sofia | Bulgaria | 1618 | |
| 201 | MHAT Trakia | Stara Zagora | Bulgaria | 6000 | |
| 202 | MHAT Sveta Marina EAD | Varna | Bulgaria | 9010 | |
| 203 | MHAT Dr Stefan Cherkezov | Veliko Tarnovo | Bulgaria | 5000 | |
| 204 | MHAT Sveti Pantaleymon - Yambol | Yambol | Bulgaria | 8600 | |
| 205 | Fraser Clinical Trials, Inc. | New Westminster | British Columbia | Canada | V3L 3W4 |
| 206 | St. Boniface Hospital | Winnipeg | Manitoba | Canada | R2H 2A6 |
| 207 | G.A. Research Associates, Ltd. | Moncton | New Brunswick | Canada | E1G 1A7 |
| 208 | Queen Elizabeth II Health Sciences Centre | Halifax | Nova Scotia | Canada | B3H 3A7 |
| 209 | Brampton Clinical Trials | Brampton | Ontario | Canada | L6Z 4N5 |
| 210 | Cambridge Cardiac Care Center | Cambridge | Ontario | Canada | N1R 6V6 |
| 211 | Vizel Cardiac Research | Cambridge | Ontario | Canada | N1R 7R1 |
| 212 | Hamilton Health Sciences - General Site | Hamilton | Ontario | Canada | L8L 2X2 |
| 213 | London Health Sciences Centre | London | Ontario | Canada | N6A 5A5 |
| 214 | KMH Cardiology Clinics Inc. | Mississauga | Ontario | Canada | L5K 2L3 |
| 215 | North York Diagnostic and Cardiac Centre | North york | Ontario | Canada | M6B 3H7 |
| 216 | Oakville Cardiovascular Research | Oakville | Ontario | Canada | L6K 3W7 |
| 217 | Office of Dr. James Cha, MD | Oshawa | Ontario | Canada | L1J 2K1 |
| 218 | Kawartha Cardiology Clinical Trials | Peterborough | Ontario | Canada | K9J 0B2 |
| 219 | Corcare | Scarborough | Ontario | Canada | M1B 5N1 |
| 220 | Medicus MFC Inc. | Toronto | Ontario | Canada | M4P 1E4 |
| 221 | Women's College Hospital | Toronto | Ontario | Canada | M5F 1B2 |
| 222 | Mount Sinai Hospital | Toronto | Ontario | Canada | M5G 1X5 |
| 223 | Centre intégré de santé et de services sociaux de Laval, Hôp | Laval | Quebec | Canada | H7M 3L9 |
| 224 | Clinique Sante Cardio MC | Montreal | Quebec | Canada | H1T 3Y7 |
| 225 | Centre Hospitalier de l'Université de Montréal-CHUM | Montreal | Quebec | Canada | H2X 0C1 |
| 226 | Montreal General Hospital | Montreal | Quebec | Canada | H3G 1A4 |
| 227 | Centre Integre de sante et de services sociaux de Lanaudiere | Terrebonne | Quebec | Canada | J6V 2H2 |
| 228 | CHUS - Ctr Hosp Univer de Sherbrooke - Hopital Hotel-Dieu | Sherbrooke | Canada | J1G 2E8 | |
| 229 | Fujian Provincial Hospital | Fuzhou | Fujian | China | 350001 |
| 230 | Lanzhou University Second Hospital | Lanzhou | Gansu | China | 730030 |
| 231 | The First Affiliated Hospital of Sun Yat-Sen University | Guangzhou | Guangdong | China | 510080 |
| 232 | Guangdong Provincial People's Hospital | Guangzhou | Guangdong | China | 510100 |
| 233 | Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ. | Guangzhou | Guangdong | China | 510120 |
| 234 | The First Affiliated Hospital of GZ Medical University | Guangzhou | Guangdong | China | 510120 |
| 235 | The First Affiliated Hospital of Guangzhou University of TCM | Guangzhou | Guangdong | China | 510405 |
| 236 | Nanfang Hospital, Southern Medical University | Guangzhou | Guangdong | China | 510515 |
| 237 | The First Affiliated Hospital of Jinan University | Guangzhou | Guangdong | China | 510630 |
| 238 | Guizhou Provincial People's Hospital | Guiyang | Guizhou | China | 550002 |
| 239 | Hainan Provincial People's Hospital | Haikou | Hainan | China | 570311 |
| 240 | Hainan Third People's Hospital (Province Nongken Sanya Hopt) | Sanya | Hainan | China | 572000 |
| 241 | The First Hospital of Hebei Medical Univesity | Shijiazhuang | Hebei | China | 050000 |
| 242 | Daqing Oilfield General Hospital | Daqing | Heilongjiang | China | 163000 |
| 243 | Xinxiang Central Hospital | Xinxiang | Henan | China | 453000 |
| 244 | Changsha Central Hospital | Changsha | Hunan | China | 410004 |
| 245 | Hunan Provincial People's Hospital | Changsha | Hunan | China | 410005 |
| 246 | The Third Xiangya Hospital of Central South University | Changsha | Hunan | China | 410013 |
| 247 | Affiliated Hospital of Inner Mongolia Medical University | Hohehot | Inner Mongolia | China | 010050 |
| 248 | Huai'an First People's Hospital, Nanjing Medical University | Huai'An | Jiangsu | China | 223300 |
| 249 | The First People's Hospital of Lianyungang | Lianyungang | Jiangsu | China | 222002 |
| 250 | Nanjing Jiangning Hospital | Nanjing | Jiangsu | China | 210000 |
| 251 | NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School | Nanjing | Jiangsu | China | 210008 |
| 252 | Zhongda Hospital Southeast University | Nanjing | Jiangsu | China | 210009 |
| 253 | The Second Affiliated Hospital of Nanjing Medical university | Nanjing | Jiangsu | China | 210011 |
| 254 | Jiangsu Province Hospital | Nanjing | Jiangsu | China | 210029 |
| 255 | 1st Affiliated hospital of Soochow University | Suzhou | Jiangsu | China | 215006 |
| 256 | The First Hospital of Jilin University | Changchun | Jilin | China | 130000 |
| 257 | Jilin Province People's Hospital | Changchun | Jilin | China | 130021 |
| 258 | Dalian Central Hospital | Dalian | Liaoning | China | 116033 |
| 259 | Panjin Liaohe Oilfield Gem Flower Hospital | Panjin | Liaoning | China | 124010 |
| 260 | The First People's Hospital of Yinchuan | Yinchuan | Ningxia | China | 750001 |
| 261 | General Hospital of Ningxia Medical University | Yinchuan | Ningxia | China | 750004 |
| 262 | Jinan Central Hospital | Jinan | Shandong | China | 250013 |
| 263 | Shanxi Provincial People's Hospital | Taiyuan | Shanxi | China | 030012 |
| 264 | The First Affiliated Hospital of Xi'an Jiaotong University | Xi'an | Shanxi | China | 710061 |
| 265 | Shaanxi Provincial People's Hospital | Xi'an | Shanxi | China | 710068 |
| 266 | West China Hospital Sichuan University | Chengdu | Sichuan | China | 610041 |
| 267 | SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos | Chengdu | Sichuan | China | 610072 |
| 268 | People's Hospital of Xinjiang Uygur Autonomous Region | Urumqi | Xinjiang | China | 830001 |
| 269 | The First Affiliated Hospital of Xinjiang Medical University | Urumqi | Xinjiang | China | 830054 |
| 270 | 1st Affiliated Hospital of College Medicine, Zhejiang Univ. | Hanghzou | Zhejiang | China | 310009 |
| 271 | ZheJiang Provincial People's Hospital | Hangzhou | Zhejiang | China | 310014 |
| 272 | Beijing Anzhen Hospital, Capital Medical University | Beijing | China | 100029 | |
| 273 | Beijing Friendship Hospital, Capital Medical University | Beijing | China | 100050 | |
| 274 | Beijing Tsinghua Changgung Hospital | Beijing | China | 102218 | |
| 275 | Shanghai East Hospital Affiated to Tongji University | Shanghai | China | 200123 | |
| 276 | Shanghai Tongji Hospital of Tongji University | Shanghai | China | ||
| 277 | Tianjin People's Hospital | Tianjin | China | 300000 | |
| 278 | Tianjin Chest Hospital | Tianjin | China | ||
| 279 | Hospital General de Medellin | Medellin | Antioquia | Colombia | |
| 280 | Rodrigo Botero S.A.S | Medellín | Antioquia | Colombia | |
| 281 | Servicios de Salud Universidad de Antioquia | Medellín | Antioquia | Colombia | |
| 282 | Sociedad Médica Rionegro SOMER S.A. | Rionegro | Antioquia | Colombia | |
| 283 | Clínica de la Costa LTDA | Barranquilla | Atlántico | Colombia | |
| 284 | Corazón IPS S.A.S. | Barranquilla | Atlántico | Colombia | |
| 285 | IPS Centro Cientifico Asistencial S.A.S | Barranquilla | Atlántico | Colombia | |
| 286 | Caja de Compensación Familiar CAFAM | Bogotá | Distrito Capital De Bogotá | Colombia | 0 |
| 287 | Hospital Universitario Mayor-MÉDERI | Bogotá | Distrito Capital De Bogotá | Colombia | 0 |
| 288 | Fundación Cardiomet CEQUIN Eje Cafetero | Armenia | Quindío | Colombia | 0 |
| 289 | Instituto del Corazón de Bucaramanga | Bucaramanga | Santander | Colombia | |
| 290 | Mediservis del Tolima IPS S.A.S | Ibague | Tolima | Colombia | |
| 291 | IPS Centro Médico Imbanaco de Cali S.A. | Cali | Valle Del Cauca | Colombia | |
| 292 | Fundacio del Caribe para la Investigacio Bio-Medica (BIOS) | Barranquilla | Colombia | ||
| 293 | Clinica Colsanitas S.A, Sede Clinica Universitaria Colombia | Bogotá | Colombia | ||
| 294 | Fundación Cardioinfantil | Bogotá | Colombia | ||
| 295 | Hospital Universitario Clínica San Rafael | Bogotá | Colombia | ||
| 296 | Fundacion Cardiovascular Santa Maria | Medellín | Colombia | ||
| 297 | Hospital San Vicente Fundación | Medellín | Colombia | ||
| 298 | Hospital Universitario de San Ignacio | Santa Fe De Bogotá | Colombia | ||
| 299 | Kardiologie MUDr. Libor Nechvatal s.r.o. | Brno | Czechia | 602 00 | |
| 300 | Kardiologicka ambulance Brno s.r.o. | Brno | Czechia | 612 00 | |
| 301 | Fakultni nemocnice Brno | Brno | Czechia | 625 00 | |
| 302 | Kardiologicka ambulance | Cesky Krumlov | Czechia | 381 01 | |
| 303 | Kardio Chlumec s.r.o.- Kardiologická ambulance | Chlumec nad Cidlinou | Czechia | 503 51 | |
| 304 | Poliklinika Dolni Brezany | Dolni Brezany | Czechia | 252 41 | |
| 305 | Fakultni Nemocnice Hradec Kralove | Hradec kralove | Czechia | 500 05 | |
| 306 | Oblastni Nemocnice Kladno | Kladno | Czechia | 27259 | |
| 307 | LUNACOR, Centrum pro choroby srdce a cev | Kromeriz | Czechia | 767 01 | |
| 308 | Kromerizska nemocnice a.s. | Kromeriz | Czechia | 767 55 | |
| 309 | Krajska Nemocnice Liberec a.s. | Liberec | Czechia | 460 63 | |
| 310 | KardioBusak s.r.o. | Louny | Czechia | 440 01 | |
| 311 | Mestska nemocnice Ostrava-City Hospital Ostrava | Ostrava | Czechia | 728 80 | |
| 312 | Kardiologicka a interni ambulance - Pisek | Pisek | Czechia | 397 01 | |
| 313 | Fakultni nemocnice Plzen | Plzen - Bory | Czechia | 305 99 | |
| 314 | Polabska zdravotni, s.r.o. | Podebrady | Czechia | 290 01 | |
| 315 | Affidea Praha s.r.o | Praha 11 | Czechia | 148 00 | |
| 316 | Vseobecna fakultni nemocnice v Praze | Praha 2 | Czechia | 12808 | |
| 317 | Institut Klinicke a Experimentalni Mediciny | Praha 4 | Czechia | 140 21 | |
| 318 | Fakultni nemocnice v Motole | Praha 5 | Czechia | 150 06 | |
| 319 | Ustredni vojenska nemocnice Praha | Praha 6 | Czechia | 169 02 | |
| 320 | Kardio s.r.o. | Trebic | Czechia | 674 01 | |
| 321 | Nemocnice Podlesi | Trinec | Czechia | 739 61 | |
| 322 | Angiocor s.r.o. | Zlin | Czechia | 760 01 | |
| 323 | Nemocnice Znojmo | Znojmo | Czechia | 669 02 | |
| 324 | Aarhus Universitetshospital, Skejby | Aarhus N | Denmark | 8200 | |
| 325 | Sydvestjysk Hospital Esbjerg - Cardiology Research Group | Esbjerg | Denmark | 6700 | |
| 326 | Gentofte Hospital | Hellerup | Denmark | 2900 | |
| 327 | Herlev Hospital - Cardiology Research Department | Herlev | Denmark | 2730 | |
| 328 | Regionshospitalet Gødstrup - Cardiology Clinic | Herning | Denmark | 7400 | |
| 329 | Holbæk Sygehus | Holbæk | Denmark | 4300 | |
| 330 | Hvidovre Hospital | Hvidovre | Denmark | 2650 | |
| 331 | Regionshospitalet Randers | Randers | Denmark | 8930 | |
| 332 | OUH Svendborg Sygehus | Svendborg | Denmark | 5700 | |
| 333 | Jorvin sairaala | Espoo | Finland | 02740 | |
| 334 | StudyCor Oy | Jyväskylä | Finland | 40620 | |
| 335 | Seinäjoen keskussairaala | Seinäjoki | Finland | FIN 60220 | |
| 336 | Tampereen yliopistollinen sairaala, keskussairaala | Tampere | Finland | 33520 | |
| 337 | Turun yliopistollinen keskussairaala, kantasairaala | Turku | Finland | 20520 | |
| 338 | Universitätsherzzentrum Freiburg - Bad Krozingen | Bad Krozingen | Baden-Württemberg | Germany | 79189 |
| 339 | Herzklinik Ulm GbR | Ulm | Baden-Württemberg | Germany | 89077 |
| 340 | Klinikum der Universität Würzburg | Würzburg | Bayern | Germany | 97078 |
| 341 | Bethanien Krankenhaus | Frankfurt | Hessen | Germany | 60389 |
| 342 | Universitätsklinikum Greifswald | Greifswald | Mecklenburg-Vorpommern | Germany | 17475 |
| 343 | Medizinische Hochschule Hannover (MHH) | Hannover | Niedersachsen | Germany | 30625 |
| 344 | Herz- und Diabeteszentrum Nordrhein-Westfalen (HDZ NRW) | Bad Oeynhausen | Nordrhein-Westfalen | Germany | 32545 |
| 345 | Städt. Kliniken Bielefeld gGmbH | Bielefeld | Nordrhein-Westfalen | Germany | 33604 |
| 346 | Universitätsklinikum Essen | Essen | Nordrhein-Westfalen | Germany | 45147 |
| 347 | Klinikum Lüdenscheid - Märkische Kliniken GmbH | Lüdenscheid | Nordrhein-Westfalen | Germany | 58515 |
| 348 | Sana-Klinikum Remscheid GmbH | Remscheid | Nordrhein-Westfalen | Germany | 42859 |
| 349 | Forschungszentrum Ruhr - KliFoCenter GmbH | Witten | Nordrhein-Westfalen | Germany | 58455 |
| 350 | Marienhaus Klinikum Mainz | Mainz | Rheinland-Pfalz | Germany | 55131 |
| 351 | Universitätsklinikum des Saarlandes | Homburg | Saarland | Germany | 66421 |
| 352 | Kardiologische Praxis Eilenburg | Eilenburg | Sachsen | Germany | 04838 |
| 353 | Praxis Hr. Dr. med. Jens Taggeselle | Markkleeberg | Sachsen | Germany | 04416 |
| 354 | Friedrich-Schiller-Uni. Jena | Jena | Thüringen | Germany | 07740 |
| 355 | Universitätsklinikum Hamburg Eppendorf (UKE) | Hamburg | Germany | 20246 | |
| 356 | Cardiologicum Hamburg | Hamburg | Germany | 22041 | |
| 357 | KAT General Hospital of Athens | Kifisia / Athens | Attica | Greece | 14561 |
| 358 | University General Hospital of Alexandroupolis | Alexandroupoli | Greece | 68100 | |
| 359 | General Hosp of Athens "Korgialenio-Benakeio" RCH | Ampelokipi - Athens | Greece | 11526 | |
| 360 | HIPPOKRATION General Hospital of Athens | Athens | Greece | 115 27 | |
| 361 | G. GENNIMATAS General State Hospital of Athens | Athens | Greece | 11527 | |
| 362 | General Hospital of Athens "ALEXANDRA" | Athens | Greece | 11528 | |
| 363 | University General Hospital ATTIKON | Chaidari | Greece | 12462 | |
| 364 | University General Hospital of Heraklion | Heraklion | Greece | 71110 | |
| 365 | Ioannina University General Hospital | Ioannina | Greece | 45500 | |
| 366 | University General Hospital of Larissa | Larissa | Greece | 41110 | |
| 367 | Hospital SISMANOGLIO | Marousi | Greece | 15126 | |
| 368 | Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA | Nea Ionia / Athens | Greece | 142 33 | |
| 369 | University General Hospital of Patra | Patra | Greece | 26504 | |
| 370 | AHEPA University General Hospital of Thessaloniki | Thessaloniki | Greece | 546 36 | |
| 371 | Hippokration General Hospital of Thessaloniki | Thessaloniki | Greece | 54642 | |
| 372 | Prince of Wales Hospital Hong Kong | Shatin | N.T | Hong Kong | |
| 373 | Queen Mary Hospital | Hong Kong | Hong Kong | ||
| 374 | Queen Elizabeth Hospital Hong Kong | Kowloon | Hong Kong | ||
| 375 | Princess Margaret Hospital | Lai Chi Kok | Hong Kong | ||
| 376 | Cardiomobile Egeszsegugyi Szolgaltato Kft. | Balatonfured | Hungary | 8230 | |
| 377 | Budai Irgalmasrendi Korhaz | Budapest | Hungary | 1023 | |
| 378 | University of Semmelweis/ Semmelweis Egyetem | Budapest | Hungary | 1085 | |
| 379 | Gottsegen Gyorgy Orszagos Kardiologiai Intezet | Budapest | Hungary | 1096 | |
| 380 | University of Semmelweis/ Semmelweis Egyetem | Budapest | Hungary | 1122 | |
| 381 | Uzsoki Utcai Korhaz | Budapest | Hungary | 1145 | |
| 382 | Jahn Ferenc Del-Pesti Korhaz es Rendelointezet | Budapest | Hungary | 1204 | |
| 383 | Magyar Honvedseg Egeszsegugyi Kozpont | Budapest | Hungary | ||
| 384 | Dombovari Szent Lukacs Korhaz | Dombovar | Hungary | 7200 | |
| 385 | Bugat Pal Korhaz | Gyongyos | Hungary | 3200 | |
| 386 | Pharma4Trial Kft. | Gyongyos | Hungary | 3200 | |
| 387 | Csongrad Megyei Egeszsegugyi Ellato Kozpont,Hodmezovasarhely | Hodmezovasarhely | Hungary | 6800 | |
| 388 | Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz | Miskolc | Hungary | 3526 | |
| 389 | Kanizsai Dorottya Hospital | Nagykanizsa | Hungary | 8800 | |
| 390 | Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft. | Nyiregyhaza | Hungary | 4400 | |
| 391 | Coromed Smo Kft | Pecs | Hungary | 7623 | |
| 392 | Da Vinci Maganklinika | Pecs | Hungary | 7635 | |
| 393 | SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont | Szeged | Hungary | 6725 | |
| 394 | Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Szekesfehervar | Hungary | 8000 | |
| 395 | Tolna Megyei Balassa Janos Korhaz | Szekszard | Hungary | 7100 | |
| 396 | Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz | Szentes | Hungary | 6600 | |
| 397 | Max Super Speciality Hospital, Saket | New Delhi | Delhi | India | 110017 |
| 398 | Safdarjung Hospital | New Delhi | Delhi | India | 110029 |
| 399 | Lokmanya Tilak Municipal Hospital | Mumbai | Maharashtra | India | 400022 |
| 400 | Deenanath Mangeshkar Hospital | Pune | Maharashtra | India | 411004 |
| 401 | KEM hospital | Pune | Maharashtra | India | 411011 |
| 402 | Madras Medical Mission Institute | Chennai | Tamil Nadu | India | 600037 |
| 403 | Assuta Ashdod | Ashdod | Israel | 7747629 | |
| 404 | Barzilai Medical Center | Cardiology Department | Ashkelon | Israel | 7830604 | |
| 405 | Rambam Health Corporation | Haifa | Israel | 3109601 | |
| 406 | Bnai Zion Medical Center | Haifa | Israel | 3339419 | |
| 407 | Lady Davis Carmel Medical Center | Haifa | Israel | 3436212 | |
| 408 | Hadassah Hebrew University Hospital Ein Kerem | Jerusalem | Israel | 9112001 | |
| 409 | Meir Medical Center | Kfar Saba | Israel | 4428164 | |
| 410 | Health Corporation of Galilee Medical Center | Nahariya | Israel | 22100 | |
| 411 | Chaim Sheba Medical Center | Ramat Gan | Israel | 52621 | |
| 412 | Kaplan Medical Center | Rehovot | Israel | 7610001 | |
| 413 | Tel-Aviv Sourasky Medical Center | Tel Aviv | Israel | 6423906 | |
| 414 | Poriya Medical Center | Cardiology Department | Tiberius | Israel | 1528001 | |
| 415 | Health Corporation of the Ziv Medical Center (R.A.) | Zefat | Israel | 1311001 | |
| 416 | Shamir Medical Center (Assaf Harofeh) | Zrifin | Israel | 7030000 | |
| 417 | A.O.U. Mater Domini | Catanzaro | Calabria | Italy | 88100 |
| 418 | A.O.U. Policlinico Federico II Napoli | Napoli | Campania | Italy | 80131 |
| 419 | AUSL di Bologna | Bologna | Emilia-Romagna | Italy | 40133 |
| 420 | A.O.U. di Bologna Policlinico S.Orsola Malpighi | Bologna | Emilia-Romagna | Italy | 40138 |
| 421 | A.O.U. di Ferrara | Ferrara | Emilia-Romagna | Italy | 44124 |
| 422 | AUSL di Piacenza | Piacenza | Emilia-Romagna | Italy | 29121 |
| 423 | ASST Papa Giovanni XXIII | Bergamo | Lombardia | Italy | 24127 |
| 424 | ASST del Garda | Brescia | Lombardia | Italy | 25085 |
| 425 | ASST Spedali Civili di Brescia | Brescia | Lombardia | Italy | 25123 |
| 426 | ASST di Cremona | Cremona | Lombardia | Italy | 26100 |
| 427 | Istituto Clinico Humanitas - Humanitas Mirasole S.p.A. | Milano | Lombardia | Italy | 20089 |
| 428 | Ospedale San Raffaele s.r.l. | Milano | Lombardia | Italy | 20132 |
| 429 | IRCCS Centro Cardiologico Monzino S.p.A | Milano | Lombardia | Italy | 20138 |
| 430 | IRCCS Istituti Clinici Scientifici Maugeri SpA SB | Milano | Lombardia | Italy | 20138 |
| 431 | ASST di Monza | Monza Brianza | Lombardia | Italy | 20090 |
| 432 | ASST della Brianza | Monza Brianza | Lombardia | Italy | 20871 |
| 433 | Fondazione IRCCS Policlinico San Matteo | Pavia | Lombardia | Italy | 27100 |
| 434 | ASST Valle Olona | Varese | Lombardia | Italy | 21047 |
| 435 | ASST Sette Laghi | Varese | Lombardia | Italy | 21049 |
| 436 | A.O.U. Maggiore della Carità | Novara | Piemonte | Italy | 28100 |
| 437 | AUSL Toscana Sud-Est | Arezzo | Toscana | Italy | 52044 |
| 438 | A.O.U. Senese | Siena | Toscana | Italy | 53100 |
| 439 | A.O. di Perugia | Perugia | Umbria | Italy | 06129 |
| 440 | A.O.U.I. Verona | Verona | Veneto | Italy | 37126 |
| 441 | Kasugai Municipal Hospital | Kasugai | Aichi | Japan | 486-8510 |
| 442 | TOYOTA Memorial Hospital | Toyota | Aichi | Japan | 471-8513 |
| 443 | Funabashi Municipal Medical Center | Funabashi | Chiba | Japan | 273-8588 |
| 444 | Matsuyama Red Cross Hospital | Matsuyama | Ehime | Japan | 790-8524 |
| 445 | Steel Memorial Yawata Hospital | Kitakyushu | Fukuoka | Japan | 805-8508 |
| 446 | Onga Nakama Medical Association Onga Hospital | Onga-gun | Fukuoka | Japan | 811-4342 |
| 447 | Ogaki Municipal Hospital | Ogaki | Gifu | Japan | 503-8502 |
| 448 | Shobara Red Cross Hospital | Shobara | Hiroshima | Japan | 727-0013 |
| 449 | Hokkaido University Hospital | Sapporo | Hokkaido | Japan | 060-8648 |
| 450 | Hyogo Prefectural HarimaHimeji General Medical Center | Himeji | Hyogo | Japan | 670-8560 |
| 451 | National Hospital Organization Kobe Medical Center | Kobe | Hyogo | Japan | 654-0155 |
| 452 | Higashi Takarazuka Satoh Hospital | Takarazuka | Hyogo | Japan | 665-0873 |
| 453 | JA Toride Medical Center | Toride | Ibaraki | Japan | 302-0022 |
| 454 | Public Central Hospital of Matto Ishikawa | Hakusan | Ishikawa | Japan | 924-8588 |
| 455 | National Hospital Organization Kanazawa Medical Center | Kanazawa | Ishikawa | Japan | 920-8650 |
| 456 | Iwate Prefectural Central Hospital | Morioka | Iwate | Japan | 020-0066 |
| 457 | Mitoyo General Hospital | Kanonji | Kagawa | Japan | 769-1695 |
| 458 | Kagawa Prefectural Central Hospital | Takamatsu | Kagawa | Japan | 760-8557 |
| 459 | Kitasato University Hospital | Sagamihara | Kanagawa | Japan | 252-0375 |
| 460 | Sagamihara Kyodo Hospital | Sagamihara | Kanagawa | Japan | 252-5188 |
| 461 | Japan Red Cross Society Azumino Hospital | Azumino | Nagano | Japan | 399-8292 |
| 462 | National Hospital Organization Shinshu Ueda Medical Center | Ueda | Nagano | Japan | 386-8610 |
| 463 | R.I.A.C Naha City Hospital | Naha | Okinawa | Japan | 902-8511 |
| 464 | Kishiwada Tokushukai Hospital | Kishiwada | Osaka | Japan | 596-0042 |
| 465 | Takatsuki Red Cross Hospital | Takatsuki | Osaka | Japan | 569-1096 |
| 466 | Ageo Central General Hospital | Ageo | Saitama | Japan | 362-8588 |
| 467 | Kawaguchi Cardiovascular and Respiratory Hospital | Kawaguchi | Saitama | Japan | 333-0842 |
| 468 | Saitama Sekishinkai Hospital | Sayama | Saitama | Japan | 350-1305 |
| 469 | National Hospital Organization Hamada Medical Center | Hamada | Shimane | Japan | 697-8511 |
| 470 | Nishiarai Heart Central Clinic | Adachi-ku | Tokyo | Japan | 123-0845 |
| 471 | Minamino Cardiovascular Hospital | Hachioji | Tokyo | Japan | 192-0918 |
| 472 | National Hospital Organization Tokyo Medical Center | Meguro-ku | Tokyo | Japan | 152-8902 |
| 473 | Toho University Omori Medical Center | Ota-ku | Tokyo | Japan | 143-8541 |
| 474 | Sanin Rosai Hospital | Yonago | Tottori | Japan | 683-8605 |
| 475 | National Hospital Organization Iwakuni Clinical Center | Iwakuni | Yamaguchi | Japan | 740-8510 |
| 476 | JCHO Shimonoseki Medical Center | Shimonoseki | Yamaguchi | Japan | 750-0061 |
| 477 | Fukuoka University Hospital | Fukuoka | Japan | 814-0180 | |
| 478 | Fukuoka University Nishijin Hospital | Fukuoka | Japan | 814-8522 | |
| 479 | Gifu Prefectural General Medical Center | Gifu | Japan | 500-8717 | |
| 480 | National Hospital Organization Kumamoto Medical Center | Kumamoto | Japan | 860-0008 | |
| 481 | Kumamoto University Hospital | Kumamoto | Japan | 860-8556 | |
| 482 | Miyazaki Medical Association Hospital | Miyazaki | Japan | 880-2102 | |
| 483 | Shinrakuen Hospital | Niigata | Japan | 950-2087 | |
| 484 | Oita Prefectural Hospital | Oita | Japan | 870-8511 | |
| 485 | The Sakakibara Heart Institute of Okayama | Okayama | Japan | 700-0804 | |
| 486 | Osaka Police Hospital | Osaka | Japan | 543-0035 | |
| 487 | Osaka General Medical Center | Osaka | Japan | 558-8558 | |
| 488 | Social Corporation Keigakukai Minamiosaka Hospital | Osaka | Japan | 559-0012 | |
| 489 | Saga-Ken Medical Centre Koseikan | Saga | Japan | 840-8571 | |
| 490 | Toyama University Hospital | Toyama | Japan | 930-0194 | |
| 491 | Seiyu Memorial Hospital | Wakayama | Japan | 649-6335 | |
| 492 | Chungbuk National University Hospital | Cheongju | Chungcheongbugdo | Korea, Republic of | 28644 |
| 493 | Yonsei University Wonju Christian Hospital | Wonju | Gang''weondo | Korea, Republic of | 26426 |
| 494 | Hallym University Sacred Heart Hospital | Anyang | Gyeonggido | Korea, Republic of | 431-070 |
| 495 | Bundang Cha Hospital | Seongnam-si | Gyeonggido | Korea, Republic of | 13496 |
| 496 | Busan National University Hospital | Busan | Korea, Republic of | 49241 | |
| 497 | Dong-A University Hospital | Busan | Korea, Republic of | 602-715 | |
| 498 | Chung Nam National University Hospital | Daejeon | Korea, Republic of | 35015 | |
| 499 | Chonnam National University Hospital | Gwangju | Korea, Republic of | 501-757 | |
| 500 | Severance Hospital, Yonsei University Health System | Seoul | Korea, Republic of | 03722 | |
| 501 | Seoul National University Hospital | Seoul | Korea, Republic of | 110-744 | |
| 502 | Daugavpils Regional Hospital | Daugavpils | Latvia | LV-5417 | |
| 503 | Jelgava Outpatient Clinic | Jelgava | Latvia | LV-3001 | |
| 504 | Liepaja Regional Hospital | Liepaja | Latvia | LV-3414 | |
| 505 | 1st Riga Clinical Hospital | Riga | Latvia | LV-1001 | |
| 506 | P. Stradins Clinical University Hospital | Riga | Latvia | LV-1002 | |
| 507 | GK Neiroklinika | Riga | Latvia | LV-1024 | |
| 508 | Gita Rancane - cardiology private practice | Ventspils | Latvia | LV-3601 | |
| 509 | UAB "Klinikiniai sprendimai" Alytus | Alytus | Lithuania | LT-63200 | |
| 510 | LUHS Kauno Hospital (Laisves ave.) | Kaunas | Lithuania | LT-44320 | |
| 511 | LUHS Kauno Hospital (Josvainiu str.) | Kaunas | Lithuania | LT-47144 | |
| 512 | Saules family medicine center | Kaunas | Lithuania | LT-49449 | |
| 513 | PI Kedainiai Hospital | Kedainiai | Lithuania | LT-57164 | |
| 514 | Klaipeda Seamen's Hospital | Klaipeda | Lithuania | LT-92288 | |
| 515 | Siauliai Republican hospital | Siauliai | Lithuania | 76231 | |
| 516 | Vilnius University Hospital Santaros Klinikos | Vilnius | Lithuania | LT-08661 | |
| 517 | Vilnius University Hospital Santaros Klinikos | Vilnius | Lithuania | LT-08661 | |
| 518 | Institute Jantung Negara | Kuala Lumpur | Malaysia | 50400 | |
| 519 | University Malaya Medical Centre | Kuala Lumpur | Malaysia | 59100 | |
| 520 | Hospital Raja Permaisuri Bainun | Perak | Malaysia | 30450 | |
| 521 | Gleneagles Penang Medical Center | Pulau Pinang | Malaysia | 10050 | |
| 522 | Hospital Pulau Pinang | Pulau Pinang | Malaysia | 10450 | |
| 523 | Sarawak Heart Centre | Sarawak | Malaysia | 94300 | |
| 524 | Hospital Serdang | Selangor | Malaysia | 43000 | |
| 525 | Centro de Investigación Médica Dr. Alberto Bazzoni SA de CV | Torreón | Coahuila | Mexico | 27000 |
| 526 | Fundación de Atencion e Investigacion Medica Lindavista SC | Alcaldia Gustavo A. Madero | Distrito Federal | Mexico | 7300 |
| 527 | Hospital de Jesús | Alcaldía Cuauhtemoc | Distrito Federal | Mexico | 06090 |
| 528 | Hospital General de Acapulco | Acapulco | Guerrero | Mexico | 39910 |
| 529 | Consultorio de Medicina Especializada del Sector Privado | Guadalajara | Jalisco | Mexico | 44657 |
| 530 | Centro de Estudios Clinicos de Queretaro S. C. (CECLIQ) | Queretaro | Querétaro | Mexico | 76000 |
| 531 | Hospital Ángeles de Xalapa | Xalapa | Veracruz | Mexico | 91193 |
| 532 | Hospital Cardiologica Aguascalientes | Aguascalientes | Mexico | 20230 | |
| 533 | Centro de Investigacion y Atencion Integral Durango S.C. | Durango | Mexico | 34080 | |
| 534 | Hospital Central "Dr. Ignacio Morones Prieto" | San Luis Potosí | Mexico | 78240 | |
| 535 | Ziekenhuis Groep Twente | Almelo | Netherlands | 7609 PP | |
| 536 | Tergooiziekenhuizen-Blaricum | Blaricum | Netherlands | 1261 AN | |
| 537 | Deventer Ziekenhuis | Deventer | Netherlands | 7416 SE | |
| 538 | Slingeland Ziekenhuis | Doetinchem | Netherlands | 7009 BL | |
| 539 | Ziekenhuis Gelderse Vallei | EDE | Netherlands | 6716 RP | |
| 540 | Catharina Ziekenhuis | Eindhoven | Netherlands | 5623 EJ | |
| 541 | Universitair Medisch Centrum Groningen | Groningen | Netherlands | 9700 RB | |
| 542 | Ziekenhuis St. Jansdal | Harderwijk | Netherlands | 3844 DG | |
| 543 | Maastricht UMC | Maastricht | Netherlands | 6229 HX | |
| 544 | Diaconessenhuis Meppel | Meppel | Netherlands | 7943 KA | |
| 545 | Antonius Ziekenhuis Sneek | Sneek | Netherlands | 8601 ZR | |
| 546 | ETZ TweeSteden Ziekenhuis (vh Maria Ziekenhuis) | Tilburg | Netherlands | 5042 AD | |
| 547 | Maxima Medisch Centrum, locatie Veldhoven | Veldhoven | Netherlands | 5504 DB | |
| 548 | University of Auckland | Auckland | New Zealand | 1023 | |
| 549 | Christchurch Heart Institute | Christchurch | New Zealand | 8140 | |
| 550 | Dunedin Hospital | Dunedin | New Zealand | 9016 | |
| 551 | P3 Research Ltd Hawkes Bay | Hawkes Bay | New Zealand | 4130 | |
| 552 | Hutt Hospital | Lower Hutt | New Zealand | 5010 | |
| 553 | Nelson Hospital | Nelson | New Zealand | 7042 | |
| 554 | P3 Research | Tauranga | New Zealand | 3110 | |
| 555 | MICS Centrum Medyczne Bydgoszcz | Bydgoszcz | Poland | 85-065 | |
| 556 | Szpital Uniwersytecki Nr 2 im. J. Bizela | Bydgoszcz | Poland | 85-168 | |
| 557 | KLIMED Marek Klimkiewicz | Dzialki | Poland | 96-315 | |
| 558 | Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej | Gdynia | Poland | ||
| 559 | Samodzielny Publiczny Specjalistyczny Szpital Zachodni | Grodzisk Mazowiecki | Poland | 05-825 | |
| 560 | CLINICAL MEDICAL RESEARCH Sp. z o. o. | Katowice | Poland | 40-156 | |
| 561 | NZOZ Terapia Optima | Katowice | Poland | 40-752 | |
| 562 | Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn | Krakow | Poland | 31-271 | |
| 563 | Wojewodzki Specjalistyczny Szpital im. dr Wl. Bieganskiego | Lodz | Poland | 91-347 | |
| 564 | IMEDICA Centrum Medyczne | Lublin | Poland | 20-068 | |
| 565 | NZOZ "Twoja Przychodnia" Sp. z o.o. | Lublin | Poland | 20-857 | |
| 566 | Zechowicz Medeusz-Plus Lekarska Spolka Partnerska | Olsztyn | Poland | 10-010 | |
| 567 | Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o. | Oswiecim | Poland | 32-600 | |
| 568 | Szpital Kliniczny Przemienienia Panskiego | Poznan | Poland | 61-848 | |
| 569 | Szpital Specjalistyczny SPZOZ | Pulawy | Poland | 24-100 | |
| 570 | NZOZ Pro-Cordis Sopockie Centrum Badan Kardiologicznych | Sopot | Poland | 81-717 | |
| 571 | Twoja Przychodnia - Szczecinskie Centrum Medyczne | Szczecin | Poland | 71-434 | |
| 572 | Gessek Jacek Prywatny Gabinet Lekarski | Torun | Poland | 87-100 | |
| 573 | Medicor PLUS Kardiolodzy sp. z o. o. | Wloclawek | Poland | 87-800 | |
| 574 | Hospital Senhora da Oliveira - Guimaraes | Guimaraes | Braga | Portugal | 4835-044 |
| 575 | CHCB - Hospital Pero da Covilha | Covilha | Castelo Branco | Portugal | 6200-251 |
| 576 | ULSM - Hospital Pedro Hispano | Matosinhos | Porto | Portugal | 4464-513 |
| 577 | Hospital da Luz - Setubal | Setubal | Setúbal | Portugal | 2900-722 |
| 578 | Hospital Prof. Dr. Fernando Fonseca | Amadora | Portugal | 2720-276 | |
| 579 | CHBV - Hospital Infante D. Pedro | Aveiro | Portugal | 3810-501 | |
| 580 | CHUC - Hospitais da U. Coimbra - Servico de Cardiologia | Coimbra | Portugal | 3004-561 | |
| 581 | ULSG - Unidade Local de Saude da Guarda | Guarda | Portugal | 6300-659 | |
| 582 | CHL - Hospital Santo Andre | Leiria | Portugal | 2410-197 | |
| 583 | Centro Hospitalar de Lisboa Ocidental | Lisboa | Portugal | 1449-005 | |
| 584 | Hospital da Luz - Lisboa | Lisboa | Portugal | 1500-650 | |
| 585 | Centro Hospitalar Universitario do Porto | Porto | Portugal | 4099-001 | |
| 586 | CMI. Dr. Podoleanu Cristian | Targu Mures | Mures | Romania | |
| 587 | Spitalul Clinic Municipal de Urgenta "Timisoara" | Timisoara | Timis | Romania | 300040 |
| 588 | Sf Pantelimon Emergency County Hospital Focsani | Focsani | Vrancea | Romania | 620034 |
| 589 | Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare | Baia Mare | Romania | 430031 | |
| 590 | Emergency County Hospital, Braila | Braila | Romania | 810318 | |
| 591 | S.C Thera Card S.R.L | Brasov | Romania | ||
| 592 | Emergency Institute for Cardiovascular Diseases | Bucharest | Romania | 022322 | |
| 593 | Spitalul Clinic de Urgenta Sf. Ioan | Bucharest | Romania | 042122 | |
| 594 | Spitatul Universitar de Urgenta Bucaresti | Bucharest | Romania | 050098 | |
| 595 | Emergency Institute for Cardiovascular Diseases | Bucuresti | Romania | 022322 | |
| 596 | Prof.Dr.Th. Burghele Clinical Hospital | Bucuresti | Romania | 50659 | |
| 597 | Spitalul Clinic de Urgenta "Sf. Pantelimon" | Bucuresti | Romania | ||
| 598 | Clinical Emergency County Hospital | Cluj-Napoca | Romania | 400006 | |
| 599 | Emergency Clinical County Hospital Craiova | Craiova Dolj | Romania | 200642 | |
| 600 | Sf. Ap. Andrei Emergency Clinical County Hospital Galati | Galati | Romania | 800578 | |
| 601 | S.C. CARDIOMED S.R.L. Iasi | Iasi | Romania | 700732 | |
| 602 | S.C. Sal Med SRL | Pitesti | Romania | ||
| 603 | S.C. Cardio Med S.R.L. | Targu Mures | Romania | 540124 | |
| 604 | Municipal Clinical Emergency Hospital of Timisoara | Timisoara | Romania | 300079 | |
| 605 | Timisoara Institute of Cardiovascular Diseases | Timisoara | Romania | 300310 | |
| 606 | SBHI of Sverdlovsk Region Aramil City Hospital | Aramil | Russian Federation | 624003 | |
| 607 | First City Clinical Hospital n.a. E.E. Volosevich | Arkhangelsk | Russian Federation | 163001 | |
| 608 | Altai Regional Cardiological Dispensary | Barnaul | Russian Federation | 656055 | |
| 609 | SBEI "Chita State Medical Academy" | Chita | Russian Federation | 672000 | |
| 610 | RBHI "Cardiological Dispensary" | Ivanovo | Russian Federation | 153012 | |
| 611 | Izhevsk City Clinical Hospital #9 | Izhevsk | Russian Federation | 426063 | |
| 612 | Kazan Federal University | Kazan | Russian Federation | 420008 | |
| 613 | Clinical Diagnostic Center | Kazan | Russian Federation | 420101 | |
| 614 | Sci-Res. Institute of Complex Cardiovascular Disorders | Kemerovo | Russian Federation | 650002 | |
| 615 | Center of cardiology and neurology | Kirov | Russian Federation | 610014 | |
| 616 | Research center of therapy and prophylactic medicine | Moscow | Russian Federation | 101990 | |
| 617 | City clinical hospital n.a. V.V. Vinogradov | Moscow | Russian Federation | 117292 | |
| 618 | Moscow State University n.a. M.V. Lomonosov | Moscow | Russian Federation | 119192 | |
| 619 | City Clinical Hospital #51 | Moscow | Russian Federation | 121309 | |
| 620 | Russian Clinical and Research Center of Gerontology | Moscow | Russian Federation | 129226 | |
| 621 | State Novosibirsk Regional Clinical Hospital | Novosibirsk | Russian Federation | 630087 | |
| 622 | Omsk Region "Clinical Health Unit No. 9" | Omsk | Russian Federation | 644018 | |
| 623 | Penza Regional Clinical Hospital n.a. N.N. Burdenko | Penza | Russian Federation | 440026 | |
| 624 | Perm Regional Hospital for War Veterans | Perm | Russian Federation | 614097 | |
| 625 | Rostov-on-Don Emergency Clinical Hospital | Rostov-on-Don | Russian Federation | 344068 | |
| 626 | SBI of the Ryazan region "Regional clinical hospital" | Ryazan | Russian Federation | 390039 | |
| 627 | Samara Regional Clinical Cardiology Dispensary n.a. Polyakov | Samara | Russian Federation | 443070 | |
| 628 | Clinical Hospital #3 n.a. S.R. Mirotvortsev | Saratov | Russian Federation | 410054 | |
| 629 | Scien. Res. Inst. of Emergency Care n.a. I.I. Dzhanelidze | St. Petersburg | Russian Federation | 192242 | |
| 630 | St. Petersburg Clinical Hospital of RAS | St. Petersburg | Russian Federation | 194017 | |
| 631 | City hospital #15 | St. Petersburg | Russian Federation | 198205 | |
| 632 | City Pokrovskaya Hospital | St. Petersburg | Russian Federation | 199106 | |
| 633 | LLC Astarta | St. Petersburg | Russian Federation | 199226 | |
| 634 | Scientific Research Institute of Cardiology | Tomsk | Russian Federation | 634012 | |
| 635 | Tomsk Regional Clinical Hospital | Tomsk | Russian Federation | 634063 | |
| 636 | Clinical Hospital for Emergency Care n.a. N.V.Solovyov | Yaroslavl | Russian Federation | 150003 | |
| 637 | Sverdlovsk Regional Clinical Hospital #1 | Yekaterinburg | Russian Federation | 620102 | |
| 638 | Stredoslovensky ustav srdcovych a cievnych chorob, a.s. | Banska Bystrica | Slovakia | 974 01 | |
| 639 | ALIAN s.r.o. | Bardejov | Slovakia | 085 01 | |
| 640 | Narodny ustav srdcovych a cievnych chorob, a.s | Bratislava 37 | Slovakia | 833 48 | |
| 641 | Nemocnica svateho Michala, a.s. | Bratislava | Slovakia | 811 08 | |
| 642 | Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto | Bratislava | Slovakia | 813 69 | |
| 643 | Univerzitna nemocnica Bratislava, Nemocnica Ruzinov | Bratislava | Slovakia | 826 06 | |
| 644 | KARDIO-SANUS, spol. s r.o. | Bratislava | Slovakia | 84107 | |
| 645 | Centrum interv. neuroradiologie a endovaskularnej liecby | Bratislava | Slovakia | 851 05 | |
| 646 | Nemocnica s poliklinikou Brezno, n.o. | Brezno | Slovakia | 977 01 | |
| 647 | Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho | Dolny Kubin | Slovakia | 026 14 | |
| 648 | JG-COR s.r.o. | Kosice | Slovakia | 040 01 | |
| 649 | Medical group Kosice, s.r.o. | Kosice | Slovakia | 040 01 | |
| 650 | KARDIO-ANGIO s.r.o. | Levice | Slovakia | 934 01 | |
| 651 | KardioMed s.r.o. | Lucenec | Slovakia | 984 01 | |
| 652 | MEDI M&M, s.r.o. | Moldava nad Bodvou | Slovakia | 045 01 | |
| 653 | Kardiocentrum Nitra s.r.o. | Nitra | Slovakia | 94901 | |
| 654 | KARDIOMED NZ s.r.o. | Nove Zamky | Slovakia | 940 01 | |
| 655 | MEDISPOL s.r.o. | Presov | Slovakia | 080 01 | |
| 656 | COR, s.r.o | Sahy | Slovakia | 936 01 | |
| 657 | Medivasa s.r.o. | Zilina | Slovakia | 01001 | |
| 658 | Complexo Hospitalario Universitario de Ferrol | Ferrol | A Coruña | Spain | 15405 |
| 659 | Hospital del Servei Valencià de Salud de la Vega Baja | San Bartolomé | Alicante | Spain | 03314 |
| 660 | Hospital Central de Asturias | Oviedo | Asturias | Spain | 33011 |
| 661 | Ciutat Sanitària i Universitària de Bellvitge | L'Hospitalet de Llobregat | Barcelona | Spain | 08907 |
| 662 | Hospital Santa María del Puerto | El Puerto de Santa María | Cádiz | Spain | 11500 |
| 663 | Hospital Virgen del Camino | Sanlúcar de Barrameda | Cádiz | Spain | 11540 |
| 664 | Hospital Virgen de las Montañas | Villamartín | Cádiz | Spain | 11650 |
| 665 | Hospital Dr. Negrín | Las Palmas de Gran Canaria | Las Palmas | Spain | 35020 |
| 666 | Hospital de Alta Resolución de Utrera | Utrera | Sevilla | Spain | 41710 |
| 667 | Hospital de Manises | Manises | Valencia | Spain | 46940 |
| 668 | Hospital San Rafael | A Coruña | Spain | 15006 | |
| 669 | Hospital del Mar | Barcelona | Spain | 08003 | |
| 670 | Ciutat Sanitària i Universitaria de la Vall d'Hebron | Barcelona | Spain | 08035 | |
| 671 | Hospital Reina Sofía | Córdoba | Spain | 14004 | |
| 672 | Hospital Universitario Virgen de las Nieves|Cardiologia | Granada | Spain | 18014 | |
| 673 | Hospital Universitario Arnau de Vilanova de Lleida | Lleida | Spain | 25198 | |
| 674 | Hospital Sanitas La Zarzuela | Cardiologia | Madrid | Spain | 28023 | |
| 675 | Hospital Ramón y Cajal | Medicina Interna | Madrid | Spain | 28034 | |
| 676 | Hospital Clínico Universitario San Carlos | Madrid | Spain | 28040 | |
| 677 | Hospital Universitario 12 de Octubre | Madrid | Spain | 28041 | |
| 678 | Hospital Virgen de la Victoria | Málaga | Spain | 29010 | |
| 679 | Complejo Hospitalario Ntra. Sra. de Valme | Sevilla | Spain | 41014 | |
| 680 | Hospital Clínico Universitario de Valencia | Valencia | Spain | 46010 | |
| 681 | Hospital General Universitario de Valencia | Valencia | Spain | 46014 | |
| 682 | Hospital Universitari i Politècnic La Fe | Cardiología | Valencia | Spain | 46026 | |
| 683 | Changhua Christian Hospital | Changhua | Taiwan | 50006 | |
| 684 | Mackay Memorial Hospital - Hsinchu Branch | Hsinchu City | Taiwan | 300 | |
| 685 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | Taiwan | 807 | |
| 686 | Taichung Veterans General Hospital | Taichung | Taiwan | 1650 | |
| 687 | National Taiwan University Hospital | Taipei | Taiwan | 100 | |
| 688 | Taipei Medical University Hospital | Taipei | Taiwan | 110 | |
| 689 | Taipei Veterans General Hospital | Taipei | Taiwan | 11217 | |
| 690 | Chang Gung Memorial Hospital at Linkou | Tao-Yuan | Taiwan | 333 | |
| 691 | Afyonkarahisar Saglik Bilimleri Universitesi | Afyonkarahisar | Turkey | 03218 | |
| 692 | 29 Mayis Devlet Hastanesi | Ankara | Turkey | 06105 | |
| 693 | Saglik Bilimleri Universitesi Antalya EA Hastanesi | Antalya | Turkey | 7100 | |
| 694 | Trakya Univ. Tip Fak. | Edirne | Turkey | 22030 | |
| 695 | Eskisehir Osmangazi Universitesi Tip Fakultesi | Eskisehir | Turkey | 26480 | |
| 696 | Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi | Istanbul | Turkey | 34098 | |
| 697 | Istanbul Universitesi Kardiyoloji Enstitusu | Istanbul | Turkey | 34304 | |
| 698 | Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H. | Istanbul | Turkey | ||
| 699 | Dokuz Eylul Universitesi Tip Fakultesi | Izmir | Turkey | 35100 | |
| 700 | Erciyes Universitesi Tip Fakultesi | Kayseri | Turkey | 38039 | |
| 701 | Kocaeli Universitesi Tip Fakultesi | Kocaeli | Turkey | 41380 | |
| 702 | Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi | Konya | Turkey | 42080 | |
| 703 | Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti | Kutahya | Turkey | 43040 | |
| 704 | Mersin Universitesi Tip Fakultesi | Mersin | Turkey | 33079 | |
| 705 | Cherkasy Regional Cardiological Center | Cherkasy | Ukraine | 18009 | |
| 706 | "Clinical Emergency Hospital" of Dnipro City Council | Dnipro | Ukraine | 49006 | |
| 707 | National Institute of Therapy named after L.T.Maloyi | Kharkiv | Ukraine | 61039 | |
| 708 | Regional Dispensary of Radiation Protection of Population | Kharkiv | Ukraine | 61166 | |
| 709 | Miska Klinichna likarnya No 8 | Kharkiv | Ukraine | 61176 | |
| 710 | City Clinical Hospital # 1 | Kiev | Ukraine | 02 091 | |
| 711 | Institute of Cardiology AMS | Kiev | Ukraine | 03680 | |
| 712 | Medbud-Clinic LLC | Kyiv | Ukraine | 03037 | |
| 713 | Railway Clinical Hospital #2 | Kyiv | Ukraine | 03049 | |
| 714 | LLC Medical Centre CONSILIUM MEDICAL | Kyiv | Ukraine | 04050 | |
| 715 | Lviv regional clinical medical & diagnostic cardiology cente | Lviv | Ukraine | 79015 | |
| 716 | Clinic of Odesa State Medical University | Odessa | Ukraine | 65009 | |
| 717 | Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi | Poltava | Ukraine | 36011 | |
| 718 | Zakarpatsky Oblasnyi Kardiologichnyi Dyspanser | Uzhgorod | Ukraine | 880000 | |
| 719 | Vinnytsia City Clinical Hospital #1 | Vinnytsia | Ukraine | 21029 | |
| 720 | Regional Clinical Hospital - Vinnytsya | Vinnytsya | Ukraine | 21018 | |
| 721 | Regional medical center of cardio-vascular disease | Zaporizhzhja | Ukraine | 69005 | |
| 722 | Zaporizhia Municipal Clinical Hospital No.10 | Zaporizhzhya | Ukraine | 69001 | |
| 723 | Zaporizhzhya City Emergency Care Hospital | Zaporizhzhya | Ukraine | 69005 | |
| 724 | Communal Institution Central City Hospital 1 of Zhytomyr | Zhytomyr | Ukraine | 10002 | |
| 725 | Torbay Hospital | Torbay | Devon | United Kingdom | TQ2 7AA |
| 726 | Royal Bournemouth General Hospital | Bournemouth | Dorset | United Kingdom | BH7 7DW |
| 727 | Poole Hospital NHS Trust | Poole | Dorset | United Kingdom | BH15 2JB |
| 728 | Queen Elizabeth University Hospital | Glasgow | Glasgow City | United Kingdom | G51 4TF |
| 729 | North Hampshire Hospital | Basingstoke | Hampshire | United Kingdom | RG24 9NA |
| 730 | Lister Hospital | Stevenage | Hertfordshire | United Kingdom | SG1 4AB |
| 731 | Blackpool Victoria Hospital | Blackpool | Lancashire | United Kingdom | FY3 8NR |
| 732 | University Hospitals Leicester | Leicester | Leicestershire | United Kingdom | LE3 9QP |
| 733 | Wansbeck General Hospital | Ashington | Northumberland | United Kingdom | NE63 9JJ |
| 734 | Russells Hall Hospital | Dudley | West Midlands | United Kingdom | DY1 2HQ |
| 735 | St Richard's Hospital | Chichester | West Sussex | United Kingdom | PO19 6SE |
| 736 | Castle Hill Hospital | Cottingham | United Kingdom | HU16 5JQ | |
| 737 | Glasgow Royal Infirmary | Glasgow Clinical Research Facility | Glasgow | United Kingdom | G31 2ER | |
| 738 | Manchester Royal Infirmary | Manchester | United Kingdom | M13 9WL | |
| 739 | Great Western Hospital | Swindon | United Kingdom | SN3 6BB |
Sponsors and Collaborators
- Bayer
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Bayer
ClinicalTrials.gov Identifier:
NCT04435626
Other Study ID Numbers:
- 20103
- 2020-000306-29
First Posted:
Jun 17, 2020
Last Update Posted:
Aug 19, 2022
Last Verified:
Aug 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Bayer
Additional relevant MeSH terms: