Heart Rate Variability and Postoperative Nausea Vomiting
Study Details
Study Description
Brief Summary
Propofol and sevoflurane have different effects on heart rate variability. It has not yet been reported whether this difference in effect remains at recovery time after anesthesia and the difference is related to postoperative nausea and vomiting has not been studied. The aim of this study is observe whether propofol and sevoflurane have different effects on heart rate variability during recovery and the differences can predict the occurrence of postoperative nausea and vomiting.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Different types of anesthetics have different effects on heart rate variability. However It has not yet been reported whether this difference in effect remains at recovery time after anesthesia.
Several studies have been reported that preoperative heart rate variability predicted the occurence of postoperative nausea and vomiting. However, whether the difference in heart rate variability after anesthesia is related to the difference in postoperative nausea and vomiting has not been studied. Therefore, this study aims to observe whether propofol and sevoflurane have differences during recovery period after anesthesia in heart rate variabiliy. In addition, we want to examine that these differences during recovery period in heart rate variability can predict the occurrence of nausea and vomiting within 24 hours after surgery.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Propofol General anesthesia using propofol infusion |
Drug: Propofol
General anesthesia using propofol infusion
Other Names:
|
Sevoflurane General anesthesia using sevoflurane |
Drug: Sevoflurane
General anesthesia using sevoflurane
Other Names:
|
Outcome Measures
Primary Outcome Measures
- heart rate variability in recovery room [within 1 hour]
Postoperative heart rate variability measuring at recovery room Frequency domain result: total power, low frequency power, high frequency power, Low frequency/high frequency power ratio
Secondary Outcome Measures
- Postoperative nausea vomiting impact scale [48 hours after anesthesia]
Q1. Have you vomited or had dry-retching? 0. No Once twice 3 or more times Q2. Have you experienced a feeling of nausea? If yes, has your feeling of nausea interfered with activities of daily living? 0. not at all Sometimes often or most of the time All of the time Add the numerical responses to questions 1 and 2. (total score 0~6)
- The incidence of postoperative nausea and vomiting [48 hours after anesthesia]
the time of occurence
- Patient's satisfaction about postoperative nausea and vomiting [48 hours after anesthesia]
verbal rating scale (0~10), 0=very unsatisfied, 10=very satisfied
Eligibility Criteria
Criteria
Inclusion Criteria:
- Scheduled breast surgery under general anesthesia
Exclusion Criteria:
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Arrhythmia
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Uncooperative with the measuring heart rate variability
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Diabetes
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Hypertension on medication
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Patients taking psychiatric drugs
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Thyroid disease
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Ajou university school of medicine | Suwon | Gyeonggi-do | Korea, Republic of | 16499 |
Sponsors and Collaborators
- Ajou University School of Medicine
Investigators
- Principal Investigator: In Kyong Yi, MD, Ajou University School of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AJIRB-MED-OBS-20-293