Pegylated Liposomal Doxorubicin Hydrochloride With Atezolizumab and/or Bevacizumab in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Active, not recruiting
CT.gov ID
NCT02839707
Collaborator
NRG Oncology (Other)
444
929
3
73.6
0.5
0

Study Details

Study Description

Brief Summary

This phase II/III trial studies how well pegylated liposomal doxorubicin hydrochloride with atezolizumab and/or bevacizumab work in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has come back (recurrent). Chemotherapy drugs, such as pegylated liposomal doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. It is not yet known which combination will work better in treating patients with ovarian, fallopian tube, or primary peritoneal cancer.

Detailed Description

PRIMARY OBJECTIVES:
  1. Estimate the probability of a dose limiting toxicity (DLT) following cycle 1 of experimental regimens (pegylated liposomal doxorubicin hydrochloride [pegylated liposomal doxorubicin] [PLD] and atezolizumab and PLD/bevacizumab and atezolizumab). (Safety lead-in)
  2. Estimate and compare the hazard of first progression or death (progression free survival [PFS]) of each experimental regimen relative to the reference regimen, PLD and bevacizumab. (Phase II study) III. Estimate and compare the hazard of death and the hazard of first progression or death (PFS) of the experimental regimen relative to the reference regimen. (Phase III) (24-FEB-2021)
SECONDARY OBJECTIVES:
  1. Estimate and compare the probabilities of response (objective response rate [ORR], either partial or complete response) defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 criteria on each study regimen. (Phase II study) (24-FEB-2021) II. Estimate the frequency and severity of adverse events as classified and graded with Common Terminology Criteria for Adverse Events (CTCAE) in those patients who initiate their randomly assigned study treatment. (Phase II study) (03/19/2018) III. Estimate and compare ORR in each treatment group. (Phase III study) IV. Estimate the frequency and severity of adverse events in those patients who initiate their randomly assigned study treatment. (Phase III study) V. Estimate and compare mean patient reported outcome scores (PROs) as measured by National Comprehensive Cancer Network (NCCN)-Functional Assessment of Cancer Therapy (FACT) ovarian symptom index (NFOSI)-18 disease-related symptoms (DRS). (Phase III study) VI. Estimate and compare the treatment groups on the basis of the PROs: treatment side effects (TSE), function/well-being (FWB), fatigue (Functional Assessment of Chronic Illness Therapy [FACIT]-fatigue subscale) and abdominal discomfort (FACT/Gynecologic Oncology Group [GOG]-abdominal discomfort [AD] subscale). (Phase III study) (10/16/2017)
TRANSLATIONAL SCIENCE OBJECTIVES:
  1. To determine whether biomarker levels in pre-treatment tissue, and pre- or on-treatment peripheral blood, and stool specimens are associated with ORR, PFS and/or overall survival (OS).

  2. Estimate pre-treatment PD-L1 expression on tumor cells measured by quantitative immunohistochemistry (IHC), and determine whether it is associated with the duration of PFS or overall survival. (Integrated Biomarker) III. Analysis of T cell receptor (TCR) repertoires by deep sequencing of peripheral blood samples. (Exploratory Biomarkers [10/16/2017]) IV. Tumor "immunogenicity" as determined by the neo-antigen landscape and characterization of the tumor microenvironment using next-generation sequencing, including but not limited to whole exome sequencing and/or RNA sequencing. (Exploratory Biomarkers [10/16/2017]) V. Microbiome analysis via stool sampling. (Exploratory Biomarkers [10/16/2017]) VI. To determine whether changes in quantitative biomarker parameters after the first 6 and 12 weeks of therapy predict ORR, PFS and/or OS.

OUTLINE: Patients will be randomized to 1 of 3 arms.

ARM I: Patients receive pegylated liposomal doxorubicin hydrochloride intravenously (IV) over 60 minutes on day 1 and atezolizumab IV over 30-60 minutes on days 1 and 15. (Closed to accrual as of February 09, 2021)

ARM II: Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1, bevacizumab IV over 30-90 minutes on days 1 and 15, and atezolizumab IV over 30-60 minutes on days 1 and 15.

ARM III: Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1 and bevacizumab IV over 30-90 minutes on days 1 and 15.

In all arms, cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for up to 2 years, and then every 6 months for up to 3 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
444 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Randomized, Phase II/III Study of Pegylated Liposomal Doxorubicin and CTEP-Supplied Atezolizumab Versus Pegylated Liposomal Doxorubicin, CTEP-Supplied Bevacizumab and CTEP-Supplied Atezolizumab Versus Pegylated Liposomal Doxorubicin and CTEP-Supplied Bevacizumab in Platinum Resistant Ovarian Cancer
Actual Study Start Date :
May 12, 2017
Anticipated Primary Completion Date :
Jun 30, 2023
Anticipated Study Completion Date :
Jun 30, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm I (PLD, atezolizumab)

Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1 and atezolizumab IV over 30-60 minutes on days 1 and 15. (Closed to accrual as of February 09, 2021)

Drug: Atezolizumab
Given IV
Other Names:
  • MPDL 3280A
  • MPDL 328OA
  • MPDL-3280A
  • MPDL3280A
  • MPDL328OA
  • RG7446
  • RO5541267
  • Tecentriq
  • Drug: Pegylated Liposomal Doxorubicin Hydrochloride
    Given IV
    Other Names:
  • ATI-0918
  • Caelyx
  • Dox-SL
  • Doxil
  • Doxilen
  • Doxorubicin HCl Liposomal
  • Doxorubicin HCl Liposome
  • Doxorubicin Hydrochloride Liposome
  • Duomeisu
  • Evacet
  • LipoDox
  • Lipodox 50
  • Liposomal Adriamycin
  • Liposomal Doxorubicin Hydrochloride
  • Liposomal-Encapsulated Doxorubicin
  • Pegylated Doxorubicin HCl Liposome
  • S-Liposomal Doxorubicin
  • Stealth Liposomal Doxorubicin
  • TLC D-99
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment
  • Experimental: Arm II (PLD, bevacizumab, atezolizumab)

    Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1, bevacizumab IV over 30-90 minutes on days 1 and 15, and atezolizumab IV over 30-60 minutes on days 1 and 15.

    Drug: Atezolizumab
    Given IV
    Other Names:
  • MPDL 3280A
  • MPDL 328OA
  • MPDL-3280A
  • MPDL3280A
  • MPDL328OA
  • RG7446
  • RO5541267
  • Tecentriq
  • Biological: Bevacizumab
    Given IV
    Other Names:
  • ABP 215
  • Anti-VEGF
  • Anti-VEGF Humanized Monoclonal Antibody
  • Anti-VEGF Monoclonal Antibody SIBP04
  • Anti-VEGF rhuMAb
  • Avastin
  • Bevacizumab awwb
  • Bevacizumab Biosimilar ABP 215
  • Bevacizumab Biosimilar BEVZ92
  • Bevacizumab Biosimilar BI 695502
  • Bevacizumab Biosimilar CBT 124
  • Bevacizumab Biosimilar CT-P16
  • Bevacizumab Biosimilar FKB238
  • Bevacizumab Biosimilar GB-222
  • Bevacizumab Biosimilar HD204
  • Bevacizumab Biosimilar HLX04
  • Bevacizumab Biosimilar IBI305
  • Bevacizumab Biosimilar LY01008
  • Bevacizumab Biosimilar MIL60
  • Bevacizumab Biosimilar Mvasi
  • Bevacizumab Biosimilar MYL-1402O
  • Bevacizumab Biosimilar QL 1101
  • Bevacizumab Biosimilar RPH-001
  • Bevacizumab Biosimilar SCT501
  • Bevacizumab Biosimilar Zirabev
  • Bevacizumab-awwb
  • Bevacizumab-bvzr
  • BP102
  • BP102 Biosimilar
  • HD204
  • Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer
  • Mvasi
  • MYL-1402O
  • Recombinant Humanized Anti-VEGF Monoclonal Antibody
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • Zirabev
  • Drug: Pegylated Liposomal Doxorubicin Hydrochloride
    Given IV
    Other Names:
  • ATI-0918
  • Caelyx
  • Dox-SL
  • Doxil
  • Doxilen
  • Doxorubicin HCl Liposomal
  • Doxorubicin HCl Liposome
  • Doxorubicin Hydrochloride Liposome
  • Duomeisu
  • Evacet
  • LipoDox
  • Lipodox 50
  • Liposomal Adriamycin
  • Liposomal Doxorubicin Hydrochloride
  • Liposomal-Encapsulated Doxorubicin
  • Pegylated Doxorubicin HCl Liposome
  • S-Liposomal Doxorubicin
  • Stealth Liposomal Doxorubicin
  • TLC D-99
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment
  • Active Comparator: Arm III (PLD, bevacizumab)

    Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1 and bevacizumab IV over 30-90 minutes on days 1 and 15.

    Biological: Bevacizumab
    Given IV
    Other Names:
  • ABP 215
  • Anti-VEGF
  • Anti-VEGF Humanized Monoclonal Antibody
  • Anti-VEGF Monoclonal Antibody SIBP04
  • Anti-VEGF rhuMAb
  • Avastin
  • Bevacizumab awwb
  • Bevacizumab Biosimilar ABP 215
  • Bevacizumab Biosimilar BEVZ92
  • Bevacizumab Biosimilar BI 695502
  • Bevacizumab Biosimilar CBT 124
  • Bevacizumab Biosimilar CT-P16
  • Bevacizumab Biosimilar FKB238
  • Bevacizumab Biosimilar GB-222
  • Bevacizumab Biosimilar HD204
  • Bevacizumab Biosimilar HLX04
  • Bevacizumab Biosimilar IBI305
  • Bevacizumab Biosimilar LY01008
  • Bevacizumab Biosimilar MIL60
  • Bevacizumab Biosimilar Mvasi
  • Bevacizumab Biosimilar MYL-1402O
  • Bevacizumab Biosimilar QL 1101
  • Bevacizumab Biosimilar RPH-001
  • Bevacizumab Biosimilar SCT501
  • Bevacizumab Biosimilar Zirabev
  • Bevacizumab-awwb
  • Bevacizumab-bvzr
  • BP102
  • BP102 Biosimilar
  • HD204
  • Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer
  • Mvasi
  • MYL-1402O
  • Recombinant Humanized Anti-VEGF Monoclonal Antibody
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • Zirabev
  • Drug: Pegylated Liposomal Doxorubicin Hydrochloride
    Given IV
    Other Names:
  • ATI-0918
  • Caelyx
  • Dox-SL
  • Doxil
  • Doxilen
  • Doxorubicin HCl Liposomal
  • Doxorubicin HCl Liposome
  • Doxorubicin Hydrochloride Liposome
  • Duomeisu
  • Evacet
  • LipoDox
  • Lipodox 50
  • Liposomal Adriamycin
  • Liposomal Doxorubicin Hydrochloride
  • Liposomal-Encapsulated Doxorubicin
  • Pegylated Doxorubicin HCl Liposome
  • S-Liposomal Doxorubicin
  • Stealth Liposomal Doxorubicin
  • TLC D-99
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment
  • Outcome Measures

    Primary Outcome Measures

    1. Incidence of dose limiting toxicities (DLT) of experimental regimens [Up to 28 days]

      Will be graded using Common Terminology Criteria for Adverse Events (CTCAE) version (v) 4.0 (CTCAE version 5.0 will be used beginning April 1, 2018). DLT will be assessed.

    2. Progression free survival (PFS) (Phase II) [From study enrollment to the investigator determined date of progression or death due to any cause, whichever occurs first, assessed up to 5 years]

      Will be assessed by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 criteria and will include estimates of the hazard ratios and the corresponding confidence intervals for the experimental regimen relative to the reference regimen, as well as Kaplan-Meier estimates of the survivorship function for each treatment group.

    3. PFS (Phase III) [From study enrollment to the investigator determined date of progression or death due to any cause, whichever occurs first, assessed up to 5 years]

      Will be assessed by RECIST v1.1 criteria and will include estimates of the hazard ratios and the corresponding confidence intervals for the experimental regimen relative to the reference regimen, as well as Kaplan-Meier estimates of the survivorship function for each treatment group.

    4. Overall survival (OS) (Phase III) [From study enrollment to the date of death regardless of the cause, assessed up to 5 years]

      OS will be evaluated.

    Secondary Outcome Measures

    1. Objective response rate (ORR) (partial or complete response) (Phase II) [Up to 5 years]

      Will be assessed by RECIST v1.1 criteria. Will be tabulated by treatment group, and 95% confidence intervals will be presented using Wilson's Score Method. Treatment arms will be compared using a likelihood ratio chi-square test.

    2. ORR (partial or complete response) (Phase III) [Up to 5 years]

      Will be assessed by RECIST v1.1. Will be tabulated by treatment group, and 95% confidence intervals will be presented using Wilson's Score Method. Treatment arms will be compared using a likelihood ratio chi-square test.

    3. Frequency and severity of adverse events (Phase II) [Up to 5 years]

      The maximum grade of each adverse event (AE) by system organ class and Common Toxicity Criteria (CTC) 4.0 (CTCAE version 5.0 will be used beginning April 1, 2018) specific term will be tabulated for those individuals who at least initiate study treatment. The number and percent of individuals will be tabulated by the maximum grade of their AE.

    4. Frequency and severity of adverse events (Phase III) [Up to 5 years]

      The maximum grade of each AE by system organ class and CTC 4.0 (CTCAE version 5.0 will be used beginning April 1, 2018) specific term will be tabulated for those individuals who at least initiate study treatment. The number and percent of individuals will be tabulated by the maximum grade of their AE.

    5. Disease-related symptoms (Phase II) [Up to 2 years]

      Will be assessed by the National Comprehensive Cancer Network (NCCN)- Functional Assessment of Cancer Therapy (FACT) ovarian symptom index (NFOSI)-18 disease-related symptoms (DRS). A repeated measures model will be used to estimate and compare the mean DRS-physical (P) scores for the treatment groups. Model covariates will include the patients' randomly assigned study treatment, age at enrollment onto the study, initial performance status, pre-treatment DRS-P score, assessment time and treatment-by-time interaction. The primary analyses will include only those treatments selected at the end of the phase II study and all of the patients assigned to one of these treatments during either stage 2 of the safety lead-in, phase II or phase III component of the study regardless of their compliance with the study treatment or eligibility status, provided at least one baseline (pre-treatment) and one follow-up assessment is available.

    6. Disease-related symptoms (Phase III) [Up to 2 years]

      Will be assessed by the NFOSI-18 DRS. A repeated measures model will be used to estimate and compare the mean DRS-P scores for the treatment groups. Model covariates will include the patients' randomly assigned study treatment, age at enrollment onto the study, initial performance status, pre-treatment DRS-P score, assessment time and treatment-by-time interaction. The primary analyses will include only those treatments selected at the end of the phase II study and all of the patients assigned to one of these treatments during either stage 2 of the safety lead-in, phase II or phase III component of the study regardless of their compliance with the study treatment or eligibility status, provided at least one baseline (pre-treatment) and one follow-up assessment is available.

    7. Patient reported outcomes (PRO) (Phase II) [Up to 2 years]

      Will be as measured by treatment side effects (TSE), function/well-being (FWB), fatigue and health status. Each of the other general PRO scales will be analyzed with repeated measures models. Exploratory analyses will include an assessment of the model residuals in order to evaluate the adequacy of modeling assumptions. Additional descriptive analyses will assess whether the differences in mean scores between groups vary systematically with time in a linear or quadratic fashion.

    8. Patient reported outcomes (Phase III) [Up to 2 years]

      Will be measured by TSE, FWB, fatigue and health status. Each of the other general PRO scales will be analyzed with repeated measures models. Exploratory analyses will include an assessment of the model residuals in order to evaluate the adequacy of modeling assumptions. Additional descriptive analyses will assess whether the differences in mean scores between groups vary systematically with time in a linear or quadratic fashion.

    9. PD-L1 expression [Up to 5 years]

      Will be assessed in enrolled patients using immunohistochemistry on tumors embedded in paraffin. The proportion of patients expressing PD-L1 in this patient population will be estimated. A proportional hazards model will be used to estimate the hazard of death for patients who express PD-L1 relative to those who do not express PL-D1 for each treatment group. The homogeneity of these estimated hazard ratios will then be assessed. Its association with the duration of PFS or OS will be determined.

    Other Outcome Measures

    1. Changes in quantitative biomarker parameters in tissue, blood, and stool [Baseline up to 12 weeks]

      Changes in quantitative biomarker parameters in tissue, blood, and stool will be assessed.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Patients must have the psychological ability and general health that permits completion of the study requirements and required follow up

    • Administration of study drugs (pegylated liposomal doxorubicin, bevacizumab, atezolizumab) may have an adverse effect on pregnancy and poses a risk to the human fetus, including embryo-lethality; women of child-bearing potential (WOCBP) must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 5 months (150 days) after the last dose of study agent; should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should inform her treating physician immediately. (06/29/2017)

    • Submission of tumor tissue is required for all patients; investigators should check with their site pathology department regarding release of biospecimens before approaching patients about participation in the trial

    • High grade ovarian cancer, including high grade serous; clear cell; endometrioid, grade 3; and others (adenocarcinoma, not otherwise specified [NOS]; mixed epithelial carcinoma; undifferentiated carcinoma); NOTE: low grade serous, mucinous and carcinosarcoma histologies are excluded due to their different underlying genomic features and/or clinical behavior; ovarian cancer = ovarian, fallopian tube or primary peritoneal cancer; required data element: submission of pathology report

    • Recurrent, platinum resistant ovarian cancer (defined as progression within < 6 months from completion of platinum based therapy; the date should be calculated from the last administered dose of platinum therapy)

    • 1-2 prior regimens (including primary therapy); hormonal therapies (e.g., tamoxifen, aromatase inhibitors) will not count toward the prior regimen limit; PARP inhibitors given in the maintenance setting post response to platinum-based therapy will not count as a separate regimen from the preceding platinum-based therapy. (30-OCT-2020)

    • Measurable disease (defined by RECIST v1.1) or evaluable disease (defined as solid and/or cystic abnormalities on radiographic imaging that do not meet RECIST 1.1 definitions for target lesions OR ascites and/or pleural effusion that has been pathologically demonstrated to be disease related in the setting of cancer antigen [CA] 125 >= 2 x upper limit of normal [ULN])

    • Performance status 0, 1 or 2

    • Absolute neutrophil count (ANC) >= 1,500/mcl (within 14 days prior to registration)

    • Platelets >= 100,000/mcl (within 14 days prior to registration)

    • Hemoglobin (Hgb) >= 8 g/dl (within 14 days prior to registration)

    • Creatinine =< 1.5 x institutional upper limit of normal (ULN) (within 14 days prior to registration)

    • Urine protein creatinine (UPC) ratio must be < 1.0 (within 14 days prior to registration); if UPC ratio >= 1, collection of 24-hour urine measurement of urine protein is recommended (24-hour urine protein level must be < 1000 mg for patient enrollment); If UPC ratio cannot be calculated because the urine protein is below the lower limit of detection of the assay this will not exclude the patient (10/22/2018) (30-OCT-2020); UPC ratio of spot urine is an estimation of the 24-hour urine protein excretion - a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm

    • Total bilirubin =< 1.5 x ULN (patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled) (within 14 days prior to registration)

    • Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN (AST and/or ALT =< 5 x ULN for patients with liver involvement) (within 14 days prior to registration)

    • International normalized ratio (INR) and activated partial thromboplastin time (aPTT) =< 1.5 x ULN (or on stable dose of therapeutic anticoagulation, such as low-molecular-weight heparin, warfarin or rivaroxaban) (10/16/2017)

    • Thyroid-stimulating hormone (TSH) within normal limits (Euthyroid patients on thyroid replacement therapy allowed provided TSH < ULN) (02/20/2019)

    • The patient or legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

    Exclusion Criteria:
    • Patients with prior allogeneic bone marrow transplantation or prior solid organ transplantation

    • Patients who have had systemic anticancer therapy (e.g., chemotherapy, targeted therapy including PARP inhibitors or bevacizumab) within 3 weeks prior to entering the study (30-OCT-2020)

    • Patients who have had hormonal therapy (e.g., tamoxifen, aromatase inhibitor) within 1 week prior to entering the study

    • Patients with prior treatment with anti-programmed cell death (PD)-1, anti- programmed cell death ligand (PD-L)1 or anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 therapeutic antibody or other similar agents (10/16/2017)

    • Patients with prior treatment with bevacizumab (or any other anti vascular therapy, e.g., cediranib) for platinum resistant recurrence; (Note: prior bevacizumab in initial therapy and/or platinum sensitive recurrent setting is allowed) (10/16/2017)

    • Patients with prior treatment with PLD

    • Prior radiotherapy to the abdomen or pelvis

    • Patients who have not recovered from adverse events to =< grade 1 (other than alopecia) due to agents administered more than 3 weeks earlier (10/16/2017); however, the following therapies are allowed:

    • Hormone replacement therapy or oral contraceptives

    • Herbal therapy > 1 week prior to cycle 1, day 1 (herbal therapy intended as anticancer therapy must be discontinued at least 1 week prior to cycle 1, day 1)

    • Palliative radiotherapy for bone metastases > 2 weeks prior to cycle 1, day 1

    • Treatment with any other investigational agent within 4 weeks prior to cycle 1, day 1

    • Treatment with systemic immunostimulatory agents (including, but not limited to, interferon [IFN]-alpha or interleukin [IL]-2) within 6 weeks prior to cycle 1, day 1

    • Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 2 weeks prior to cycle 1, day 1

    • Patients who have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea or steroids as computed tomography [CT] scan contrast premedication) may be enrolled

    • The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension or adrenocortical insufficiency is allowed

    • Patients taking bisphosphonate therapy for symptomatic hypercalcemia within the past 28 days; use of bisphosphonate therapy for other reasons (e.g., bone metastasis or osteoporosis) is allowed

    • Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:

    • Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:

    • Evaluable or measurable disease outside the CNS

    • No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within 10 mm of the optic apparatus (optic nerves and chiasm)

    • No history of intracranial hemorrhage or spinal cord hemorrhage

    • No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted

    • No neurosurgical resection or brain biopsy within 28 days prior to cycle 1, day 1

    • Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:

    • Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study

    • No stereotactic radiation or whole-brain radiation within 28 days prior to cycle 1, day 1

    • Screening CNS radiographic study >= 4 weeks from completion of radiotherapy and >= 2 weeks from discontinuation of corticosteroids

    • Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies

    • History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins

    • Patients requiring treatment with a receptor activator of nuclear factor kappa-B ligand (RANKL) inhibitor (e.g. denosumab) who cannot discontinue it before treatment with atezolizumab

    • Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis; cirrhosis; fatty liver; and inherited liver disease

    • Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HBsAg] test and a positive anti-HBc [antibody to hepatitis B core antigen] antibody test) are eligible

    • Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV ribonucleic acid (RNA)

    • History or risk of autoimmune disease, including but not limited to systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis (02/20/2019)

    • Patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone are eligible

    • Patients with controlled type 1 diabetes mellitus on a stable insulin regimen, or type 2 diabetes mellitus are eligible

    • Patients with eczema, psoriasis, lichen simplex chronicus or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions:

    • Patients with psoriasis must have a baseline ophthalmologic exam to rule out ocular manifestations

    • Rash must cover less than 10% of body surface area (BSA)

    • Disease is well controlled at baseline and only requiring low potency topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%, fluocinolone 0.01%, desonide 0.05%, alclometasone dipropionate 0.05%)

    • No acute exacerbations of underlying condition within the last 12 months (not requiring psoralen plus ultraviolet A radiation [PUVA], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors; high potency or oral steroids)

    • History of idiopathic pulmonary fibrosis, pneumonitis (including drug induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis on screening chest computed tomography (CT) scan; history of radiation pneumonitis in the radiation field (fibrosis) is permitted

    • Patients with active tuberculosis (TB) are excluded

    • Severe infections within 4 weeks prior to cycle 1, day 1, including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia

    • Signs or symptoms of infection within 2 weeks prior to cycle 1, day 1

    • Received oral or intravenous (IV) antibiotics within 2 weeks prior to cycle 1, day 1; patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible

    • Major surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the study

    • Administration of a live, attenuated vaccine within 4 weeks before cycle 1, day 1 or anticipation that such a live, attenuated vaccine will be required during the study and up to 5 months after the last dose of atezolizumab (06/29/2017)

    • Influenza vaccination should be given during influenza season only (approximately October to March); patients must not receive live, attenuated influenza vaccine within 4 weeks prior to cycle 1, day 1 or at any time during the study

    • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

    • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial (08-JAN-2021)

    • Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years, with the exception of those with a negligible risk of metastases or death, such as carcinoma in situ of the breast or cervix

    • Severe, active co-morbidity defined as follows:

    • Current (within 28 days of cycle 1, day 1) signs and/or symptoms of bowel obstruction

    • Patients who require parental hydration and/or nutrition

    • Patients who require drainage gastrostomy tube

    • Evidence of bleeding diathesis or clinically significant coagulopathy

    • Serious, non-healing or dehiscing wound, active ulcer or untreated bone fracture

    • History of hemoptysis (>= 1/2 teaspoon of bright red blood per episode) within 1 month of study enrollment

    • Significant cardiovascular or cerebrovascular disease including:

    • Uncontrolled hypertension (systolic blood pressure [SBP] >= 150 and/or diastolic blood pressure [DBP] >= 90)

    • History of myocardial infarction within 6 months

    • Unstable angina

    • New York Heart Association functional classification II, III or IV

    • Baseline ejection fraction =< 50% as assessed by echocardiogram or multi-gated acquisition (MUGA)

    • Cerebral vascular accident (CVA) or transient ischemic attack (TIA) within 6 months

    • Significant vascular disease (e.g., aortic aneurysm, requiring surgical repair or peripheral arterial thrombosis) within 6 months

    • History of abdominal/pelvic or tracheoesophageal fistula or gastrointestinal perforation and/or abdominal/pelvic abscess within 6 months prior to initiation of treatment (02/20/2019)

    • Pregnant or lactating patients

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
    10 CTCA at Western Regional Medical Center Goodyear Arizona United States 85338
    11 Kingman Regional Medical Center Kingman Arizona United States 86401
    12 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    13 Banner University Medical Center - Tucson Tucson Arizona United States 85719
    14 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    15 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    16 University of Arkansas for Medical Sciences Little Rock Arkansas United States 72205
    17 Kaiser Permanente-Anaheim Anaheim California United States 92806
    18 Kaiser Permanente-Deer Valley Medical Center Antioch California United States 94531
    19 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    20 PCR Oncology Arroyo Grande California United States 93420
    21 Sutter Auburn Faith Hospital Auburn California United States 95602
    22 Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California United States 95603
    23 Kaiser Permanente-Baldwin Park Baldwin Park California United States 91706
    24 Kaiser Permanente-Bellflower Bellflower California United States 90706
    25 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    26 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    27 Mills-Peninsula Medical Center Burlingame California United States 94010
    28 Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California United States 95682
    29 Mercy San Juan Medical Center Carmichael California United States 95608
    30 Eden Hospital Medical Center Castro Valley California United States 94546
    31 Community Cancer Institute Clovis California United States 93611
    32 University Oncology Associates Clovis California United States 93611
    33 John Muir Medical Center-Concord Campus Concord California United States 94520
    34 Sutter Davis Hospital Davis California United States 95616
    35 Epic Care-Dublin Dublin California United States 94568
    36 Kaiser Permanente Dublin Dublin California United States 94568
    37 Mercy Cancer Center - Elk Grove Elk Grove California United States 95758
    38 Bay Area Breast Surgeons Inc Emeryville California United States 94608
    39 Epic Care Partners in Cancer Care Emeryville California United States 94608
    40 Kaiser Permanente-Fontana Fontana California United States 92335
    41 Kaiser Permanente-Fremont Fremont California United States 94538
    42 Palo Alto Medical Foundation-Fremont Fremont California United States 94538
    43 Fresno Cancer Center Fresno California United States 93720
    44 Kaiser Permanente-Fresno Fresno California United States 93720
    45 Marin Cancer Care Inc Greenbrae California United States 94904
    46 Marin General Hospital Greenbrae California United States 94904
    47 Kaiser Permanente - Harbor City Harbor City California United States 90710
    48 Kaiser Permanente-Irvine Irvine California United States 92618
    49 Loma Linda University Medical Center Loma Linda California United States 92354
    50 Kaiser Permanente Los Angeles Medical Center Los Angeles California United States 90027
    51 Kaiser Permanente West Los Angeles Los Angeles California United States 90034
    52 Contra Costa Regional Medical Center Martinez California United States 94553-3156
    53 Memorial Medical Center Modesto California United States 95355
    54 Kaiser Permanente-Modesto Modesto California United States 95356
    55 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    56 Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California United States 94040
    57 Sutter Cancer Research Consortium Novato California United States 94945
    58 Alta Bates Summit Medical Center - Summit Campus Oakland California United States 94609
    59 Bay Area Tumor Institute Oakland California United States 94609
    60 Kaiser Permanente Oakland-Broadway Oakland California United States 94611
    61 Kaiser Permanente-Oakland Oakland California United States 94611
    62 Kaiser Permanente-Ontario Ontario California United States 91761
    63 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    64 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    65 Kaiser Permanente - Panorama City Panorama City California United States 91402
    66 Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California United States 95670
    67 Eisenhower Medical Center Rancho Mirage California United States 92270
    68 Kaiser Permanente- Marshall Medical Offices Redwood City California United States 94063
    69 Kaiser Permanente-Redwood City Redwood City California United States 94063
    70 Kaiser Permanente-Richmond Richmond California United States 94801
    71 Kaiser Permanente-Riverside Riverside California United States 92505
    72 Mercy Cancer Center - Rocklin Rocklin California United States 95765
    73 Rohnert Park Cancer Center Rohnert Park California United States 94928
    74 Kaiser Permanente-Roseville Roseville California United States 95661
    75 Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California United States 95661
    76 Sutter Roseville Medical Center Roseville California United States 95661
    77 The Permanente Medical Group-Roseville Radiation Oncology Roseville California United States 95678
    78 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    79 Mercy Cancer Center - Sacramento Sacramento California United States 95816
    80 Sutter Medical Center Sacramento Sacramento California United States 95816
    81 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    82 South Sacramento Cancer Center Sacramento California United States 95823
    83 Kaiser Permanente - Sacramento Sacramento California United States 95825
    84 Kaiser Permanente-San Diego Mission San Diego California United States 92108
    85 Kaiser Permanente-San Diego Zion San Diego California United States 92120
    86 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    87 Kaiser Permanente-San Francisco San Francisco California United States 94115
    88 UCSF Medical Center-Mission Bay San Francisco California United States 94158
    89 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    90 Kaiser Permanente San Leandro San Leandro California United States 94577
    91 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    92 Kaiser Permanente-San Marcos San Marcos California United States 92078
    93 Kaiser Permanente-San Rafael San Rafael California United States 94903
    94 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    95 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    96 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    97 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    98 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
    99 Sutter Pacific Medical Foundation Santa Rosa California United States 95403
    100 Kaiser Permanente Cancer Treatment Center South San Francisco California United States 94080
    101 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    102 Kaiser Permanente-Stockton Stockton California United States 95210
    103 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    104 Northbay Cancer Center Vacaville California United States 95687
    105 Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville California United States 95687
    106 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    107 Kaiser Permanente-Vallejo Vallejo California United States 94589
    108 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
    109 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    110 Epic Care Cyberknife Center Walnut Creek California United States 94597
    111 John Muir Medical Center-Walnut Creek Walnut Creek California United States 94598
    112 Kaiser Permanente-Woodland Hills Woodland Hills California United States 91367
    113 Woodland Memorial Hospital Woodland California United States 95695
    114 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
    115 The Medical Center of Aurora Aurora Colorado United States 80012
    116 University of Colorado Hospital Aurora Colorado United States 80045
    117 Boulder Community Hospital Boulder Colorado United States 80301
    118 Boulder Community Foothills Hospital Boulder Colorado United States 80303
    119 Rocky Mountain Cancer Centers-Boulder Boulder Colorado United States 80304
    120 Rocky Mountain Cancer Centers - Centennial Centennial Colorado United States 80112
    121 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    122 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    123 Saint Francis Cancer Center Colorado Springs Colorado United States 80923
    124 Cancer Center of Colorado at Sloan's Lake Denver Colorado United States 80204
    125 Denver Health Medical Center Denver Colorado United States 80204
    126 Kaiser Permanente-Franklin Denver Colorado United States 80205
    127 National Jewish Health-Main Campus Denver Colorado United States 80206
    128 The Women's Imaging Center Denver Colorado United States 80209
    129 Porter Adventist Hospital Denver Colorado United States 80210
    130 Colorado Blood Cancer Institute Denver Colorado United States 80218
    131 Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado United States 80218
    132 Rocky Mountain Cancer Centers-Midtown Denver Colorado United States 80218
    133 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    134 Rocky Mountain Cancer Centers-Rose Denver Colorado United States 80220
    135 Rose Medical Center Denver Colorado United States 80220
    136 Western Surgical Care Denver Colorado United States 80220
    137 Mercy Medical Center Durango Colorado United States 81301
    138 Southwest Oncology PC Durango Colorado United States 81301
    139 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    140 Rocky Mountain Cancer Centers - Swedish Englewood Colorado United States 80113
    141 Swedish Medical Center Englewood Colorado United States 80113
    142 The Melanoma and Skin Cancer Institute Englewood Colorado United States 80113
    143 Poudre Valley Hospital Fort Collins Colorado United States 80524
    144 Mountain Blue Cancer Care Center Golden Colorado United States 80401
    145 National Jewish Health-Western Hematology Oncology Golden Colorado United States 80401
    146 Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado United States 81501
    147 North Colorado Medical Center Greeley Colorado United States 80631
    148 Good Samaritan Medical Center Lafayette Colorado United States 80026
    149 Kaiser Permanente-Rock Creek Lafayette Colorado United States 80026
    150 Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado United States 80228
    151 Saint Anthony Hospital Lakewood Colorado United States 80228
    152 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
    153 Littleton Adventist Hospital Littleton Colorado United States 80122
    154 Kaiser Permanente-Lone Tree Lone Tree Colorado United States 80124
    155 Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado United States 80124
    156 Sky Ridge Medical Center Lone Tree Colorado United States 80124
    157 Longmont United Hospital Longmont Colorado United States 80501
    158 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    159 McKee Medical Center Loveland Colorado United States 80539
    160 Parker Adventist Hospital Parker Colorado United States 80138
    161 Rocky Mountain Cancer Centers-Parker Parker Colorado United States 80138
    162 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    163 Rocky Mountain Cancer Centers - Pueblo Pueblo Colorado United States 81008
    164 National Jewish Health-Northern Hematology Oncology Thornton Colorado United States 80260
    165 Rocky Mountain Cancer Centers-Thornton Thornton Colorado United States 80260
    166 SCL Health Lutheran Medical Center Wheat Ridge Colorado United States 80033
    167 Danbury Hospital Danbury Connecticut United States 06810
    168 Hartford Hospital Hartford Connecticut United States 06102
    169 The Hospital of Central Connecticut New Britain Connecticut United States 06050
    170 Norwalk Hospital Norwalk Connecticut United States 06856
    171 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    172 Beebe Medical Center Lewes Delaware United States 19958
    173 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    174 Helen F Graham Cancer Center Newark Delaware United States 19713
    175 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    176 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    177 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    178 TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware United States 19973
    179 Christiana Care Health System-Wilmington Hospital Wilmington Delaware United States 19801
    180 Kaiser Permanente-Capitol Hill Medical Center Washington District of Columbia United States 20002
    181 Sibley Memorial Hospital Washington District of Columbia United States 20016
    182 Mount Sinai Comprehensive Cancer Center at Aventura Aventura Florida United States 33180
    183 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    184 Mount Sinai Medical Center Miami Beach Florida United States 33140
    185 Sacred Heart Hospital Pensacola Florida United States 32504
    186 Sarasota Memorial Hospital Sarasota Florida United States 34239
    187 Emory University Hospital Midtown Atlanta Georgia United States 30308
    188 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    189 Emory Saint Joseph's Hospital Atlanta Georgia United States 30342
    190 Northside Hospital Atlanta Georgia United States 30342
    191 Augusta University Medical Center Augusta Georgia United States 30912
    192 Northeast Georgia Medical Center Braselton Braselton Georgia United States 30517
    193 Northside Hospital-Forsyth Cumming Georgia United States 30041
    194 Dekalb Medical Center Decatur Georgia United States 30033
    195 Northeast Georgia Medical Center-Gainesville Gainesville Georgia United States 30501
    196 CTCA at Southeastern Regional Medical Center Newnan Georgia United States 30265
    197 Low Country Cancer Care Savannah Georgia United States 31404
    198 Memorial Health University Medical Center Savannah Georgia United States 31404
    199 Summit Cancer Care-Memorial Savannah Georgia United States 31404
    200 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
    201 Summit Cancer Care-Candler Savannah Georgia United States 31405
    202 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    203 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    204 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    205 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    206 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    207 Island Urology Honolulu Hawaii United States 96813
    208 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    209 Queen's Medical Center Honolulu Hawaii United States 96813
    210 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    211 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    212 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    213 Kuakini Medical Center Honolulu Hawaii United States 96817
    214 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    215 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    216 Kaiser Permanente Moanalua Medical Center Honolulu Hawaii United States 96819
    217 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    218 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    219 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    220 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    221 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    222 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    223 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    224 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    225 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    226 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    227 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    228 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    229 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    230 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    231 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    232 Saint Anthony's Health Alton Illinois United States 62002
    233 Rush - Copley Medical Center Aurora Illinois United States 60504
    234 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    235 Illinois CancerCare-Canton Canton Illinois United States 61520
    236 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    237 SIH Cancer Institute Carterville Illinois United States 62918
    238 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    239 Centralia Oncology Clinic Centralia Illinois United States 62801
    240 Northwestern University Chicago Illinois United States 60611
    241 John H Stroger Jr Hospital of Cook County Chicago Illinois United States 60612
    242 Rush University Medical Center Chicago Illinois United States 60612
    243 University of Illinois Chicago Illinois United States 60612
    244 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    245 Carle on Vermilion Danville Illinois United States 61832
    246 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    247 Decatur Memorial Hospital Decatur Illinois United States 62526
    248 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    249 Carle Physician Group-Effingham Effingham Illinois United States 62401
    250 Crossroads Cancer Center Effingham Illinois United States 62401
    251 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    252 NorthShore University HealthSystem-Evanston Hospital Evanston Illinois United States 60201
    253 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    254 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    255 Northwestern Medicine Cancer Center Delnor Geneva Illinois United States 60134
    256 NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois United States 60026
    257 NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois United States 60035
    258 Sudarshan K Sharma MD Limited-Gynecologic Oncology Hinsdale Illinois United States 60521
    259 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    260 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    261 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    262 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    263 Loyola University Medical Center Maywood Illinois United States 60153
    264 Marjorie Weinberg Cancer Center at Loyola-Gottlieb Melrose Park Illinois United States 60160
    265 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    266 UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois United States 60451
    267 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    268 University of Chicago Medicine-Orland Park Orland Park Illinois United States 60462
    269 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    270 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    271 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    272 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    273 Illinois CancerCare-Peru Peru Illinois United States 61354
    274 Valley Radiation Oncology Peru Illinois United States 61354
    275 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    276 North Shore Medical Center Skokie Illinois United States 60076
    277 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    278 Springfield Clinic Springfield Illinois United States 62702
    279 Memorial Medical Center Springfield Illinois United States 62781
    280 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    281 Carle Cancer Center Urbana Illinois United States 61801
    282 The Carle Foundation Hospital Urbana Illinois United States 61801
    283 Northwestern Medicine Cancer Center Warrenville Warrenville Illinois United States 60555
    284 Illinois CancerCare - Washington Washington Illinois United States 61571
    285 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    286 Midwestern Regional Medical Center Zion Illinois United States 60099
    287 Parkview Hospital Randallia Fort Wayne Indiana United States 46805
    288 Parkview Regional Medical Center Fort Wayne Indiana United States 46845
    289 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    290 Franciscan Health Indianapolis Indianapolis Indiana United States 46237
    291 Saint Vincent Hospital and Health Care Center Indianapolis Indiana United States 46260
    292 Franciscan Saint Elizabeth Health - Lafayette East Lafayette Indiana United States 47905
    293 Woodland Cancer Care Center Michigan City Indiana United States 46360
    294 Franciscan Health Mooresville Mooresville Indiana United States 46158
    295 Reid Health Richmond Indiana United States 47374
    296 Memorial Hospital of South Bend South Bend Indiana United States 46601
    297 Union Hospital Terre Haute Indiana United States 47804
    298 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    299 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    300 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    301 Greater Regional Medical Center Creston Iowa United States 50801
    302 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    303 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    304 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    305 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    306 Coffeyville Regional Medical Center Coffeyville Kansas United States 67337
    307 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    308 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    309 HaysMed University of Kansas Health System Hays Kansas United States 67601
    310 University of Kansas Cancer Center Kansas City Kansas United States 66160
    311 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    312 Olathe Health Cancer Center Olathe Kansas United States 66061
    313 University of Kansas Cancer Center-Overland Park Overland Park Kansas United States 66210
    314 University of Kansas Hospital-Indian Creek Campus Overland Park Kansas United States 66211
    315 Ascension Via Christi - Pittsburg Pittsburg Kansas United States 66762
    316 Salina Regional Health Center Salina Kansas United States 67401
    317 Cotton O'Neil Cancer Center / Stormont Vail Health Topeka Kansas United States 66606
    318 University of Kansas Health System Saint Francis Campus Topeka Kansas United States 66606
    319 University of Kansas Hospital-Westwood Cancer Center Westwood Kansas United States 66205
    320 Associates In Womens Health Wichita Kansas United States 67208
    321 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    322 Baptist Health Corbin Corbin Kentucky United States 40701
    323 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    324 Saint Elizabeth Healthcare Edgewood Edgewood Kentucky United States 41017
    325 Baptist Health Lexington Lexington Kentucky United States 40503
    326 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    327 Saint Joseph Hospital East Lexington Kentucky United States 40509
    328 Saint Joseph London London Kentucky United States 40741
    329 Jewish Hospital Louisville Kentucky United States 40202
    330 Norton Hospital Pavilion and Medical Campus Louisville Kentucky United States 40202
    331 Baptist Health Louisville Louisville Kentucky United States 40207
    332 Norton Suburban Hospital and Medical Campus Louisville Kentucky United States 40207
    333 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    334 Norton Brownsboro Hospital and Medical Campus Louisville Kentucky United States 40241
    335 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    336 Baptist Health Madisonville/Merle Mahr Cancer Center Madisonville Kentucky United States 42431
    337 Baptist Health Paducah Paducah Kentucky United States 42003
    338 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    339 Baton Rouge General Medical Center Baton Rouge Louisiana United States 70806
    340 Hematology/Oncology Clinic PLLC Baton Rouge Louisiana United States 70809
    341 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
    342 Medical Center of Baton Rouge Baton Rouge Louisiana United States 70816
    343 Ochsner High Grove Baton Rouge Louisiana United States 70836
    344 Women's Cancer Care-Covington Covington Louisiana United States 70433
    345 Tulane University Health Sciences Center New Orleans Louisiana United States 70112
    346 Ochsner Baptist Medical Center New Orleans Louisiana United States 70115
    347 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    348 Eastern Maine Medical Center Bangor Maine United States 04401
    349 Lafayette Family Cancer Center-EMMC Brewer Maine United States 04412
    350 Maine Medical Center- Scarborough Campus Scarborough Maine United States 04074
    351 Greater Baltimore Medical Center Baltimore Maryland United States 21204
    352 Kaiser Permanente-Woodlawn Medical Center Baltimore Maryland United States 21244
    353 Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland United States 21287
    354 University of Maryland Shore Medical Center at Easton Easton Maryland United States 21601
    355 Kaiser Permanente-Gaithersburg Medical Center Gaithersburg Maryland United States 20879
    356 Kaiser Permanente - Kensington Medical Center Kensington Maryland United States 20895
    357 Kaiser Permanente - Largo Medical Center Largo Maryland United States 20774
    358 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    359 Lahey Medical Center-Peabody Peabody Massachusetts United States 01960
    360 Baystate Medical Center Springfield Massachusetts United States 01199
    361 Winchester Hospital Winchester Massachusetts United States 01890
    362 UMass Memorial Medical Center - Memorial Division Worcester Massachusetts United States 01605
    363 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    364 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    365 Bronson Battle Creek Battle Creek Michigan United States 49017
    366 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    367 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    368 Henry Ford Cancer Institute-Downriver Brownstown Michigan United States 48183
    369 Saint Joseph Mercy Canton Canton Michigan United States 48188
    370 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    371 Caro Cancer Center Caro Michigan United States 48723
    372 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    373 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    374 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    375 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    376 Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan United States 48038
    377 Henry Ford Medical Center-Fairlane Dearborn Michigan United States 48126
    378 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    379 Henry Ford Hospital Detroit Michigan United States 48202
    380 Ascension Saint John Hospital Detroit Michigan United States 48236
    381 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    382 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    383 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    384 Genesee Hematology Oncology PC Flint Michigan United States 48503
    385 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    386 Hurley Medical Center Flint Michigan United States 48503
    387 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    388 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    389 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    390 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    391 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    392 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    393 Allegiance Health Jackson Michigan United States 49201
    394 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    395 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    396 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    397 Borgess Medical Center Kalamazoo Michigan United States 49048
    398 Sparrow Hospital Lansing Michigan United States 48912
    399 Hope Cancer Clinic Livonia Michigan United States 48154
    400 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    401 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    402 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    403 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    404 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    405 Lakeland Hospital Niles Niles Michigan United States 49120
    406 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    407 Henry Ford Medical Center-Columbus Novi Michigan United States 48377
    408 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    409 Hope Cancer Center Pontiac Michigan United States 48341
    410 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    411 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    412 Huron Medical Center PC Port Huron Michigan United States 48060
    413 Lake Huron Medical Center Port Huron Michigan United States 48060
    414 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    415 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    416 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    417 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    418 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    419 Henry Ford Macomb Health Center - Shelby Township Shelby Michigan United States 48315
    420 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    421 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    422 Munson Medical Center Traverse City Michigan United States 49684
    423 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    424 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    425 Macomb Hematology Oncology PC Warren Michigan United States 48093
    426 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    427 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    428 Henry Ford West Bloomfield Hospital West Bloomfield Michigan United States 48322
    429 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    430 Metro Health Hospital Wyoming Michigan United States 49519
    431 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    432 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    433 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    434 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    435 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    436 Cambridge Medical Center Cambridge Minnesota United States 55008
    437 Mercy Hospital Coon Rapids Minnesota United States 55433
    438 Fairview Southdale Hospital Edina Minnesota United States 55435
    439 Unity Hospital Fridley Minnesota United States 55432
    440 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    441 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    442 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    443 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    444 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    445 Health Partners Inc Minneapolis Minnesota United States 55454
    446 Monticello Cancer Center Monticello Minnesota United States 55362
    447 New Ulm Medical Center New Ulm Minnesota United States 56073
    448 Fairview Northland Medical Center Princeton Minnesota United States 55371
    449 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    450 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    451 Regions Hospital Saint Paul Minnesota United States 55101
    452 United Hospital Saint Paul Minnesota United States 55102
    453 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    454 Lakeview Hospital Stillwater Minnesota United States 55082
    455 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    456 Ridgeview Medical Center Waconia Minnesota United States 55387
    457 Rice Memorial Hospital Willmar Minnesota United States 56201
    458 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    459 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    460 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    461 University of Mississippi Medical Center Jackson Mississippi United States 39216
    462 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    463 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    464 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    465 Cox Cancer Center Branson Branson Missouri United States 65616
    466 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    467 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    468 Parkland Health Center - Farmington Farmington Missouri United States 63640
    469 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    470 Freeman Health System Joplin Missouri United States 64804
    471 Mercy Hospital Joplin Joplin Missouri United States 64804
    472 Truman Medical Centers Kansas City Missouri United States 64108
    473 University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri United States 64116
    474 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    475 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    476 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    477 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    478 Washington University School of Medicine Saint Louis Missouri United States 63110
    479 Mercy Hospital South Saint Louis Missouri United States 63128
    480 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    481 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    482 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    483 Mercy Hospital Springfield Springfield Missouri United States 65804
    484 CoxHealth South Hospital Springfield Missouri United States 65807
    485 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    486 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    487 Mercy Hospital Washington Washington Missouri United States 63090
    488 Community Hospital of Anaconda Anaconda Montana United States 59711
    489 Billings Clinic Cancer Center Billings Montana United States 59101
    490 Saint Vincent Healthcare Billings Montana United States 59101
    491 Saint Vincent Frontier Cancer Center Billings Montana United States 59102
    492 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    493 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    494 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    495 Great Falls Clinic Great Falls Montana United States 59405
    496 Saint Peter's Community Hospital Helena Montana United States 59601
    497 Kalispell Regional Medical Center Kalispell Montana United States 59901
    498 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    499 Community Medical Hospital Missoula Montana United States 59804
    500 CHI Health Saint Francis Grand Island Nebraska United States 68803
    501 Heartland Hematology and Oncology Kearney Nebraska United States 68845
    502 CHI Health Good Samaritan Kearney Nebraska United States 68847
    503 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    504 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    505 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    506 Hematology and Oncology Consultants PC Omaha Nebraska United States 68122
    507 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    508 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    509 Creighton University Medical Center Omaha Nebraska United States 68131
    510 University of Nebraska Medical Center Omaha Nebraska United States 68198
    511 Midlands Community Hospital Papillion Nebraska United States 68046
    512 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    513 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    514 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    515 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    516 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    517 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    518 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    519 GenesisCare USA - Henderson Henderson Nevada United States 89074
    520 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    521 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    522 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    523 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    524 Desert West Surgery Las Vegas Nevada United States 89102
    525 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    526 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    527 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    528 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    529 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    530 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    531 Women's Cancer Center of Nevada Las Vegas Nevada United States 89106
    532 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    533 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    534 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    535 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    536 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    537 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    538 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    539 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    540 Cancer Therapy and Integrative Medicine Las Vegas Nevada United States 89121
    541 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    542 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    543 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    544 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    545 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    546 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    547 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    548 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    549 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    550 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    551 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    552 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    553 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    554 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    555 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    556 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    557 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    558 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    559 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    560 University Cancer Center Las Vegas Nevada United States 89169
    561 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    562 Renown Regional Medical Center Reno Nevada United States 89502
    563 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    564 Radiation Oncology Associates Reno Nevada United States 89509
    565 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
    566 Norris Cotton Cancer Center-Nashua Nashua New Hampshire United States 03063
    567 Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey United States 07920
    568 AtlantiCare Health Park-Cape May Court House Cape May Court House New Jersey United States 08210
    569 AtlantiCare Surgery Center Egg Harbor Township New Jersey United States 08234
    570 Hackensack University Medical Center Hackensack New Jersey United States 07601
    571 The Cancer Institute of New Jersey Hamilton Hamilton New Jersey United States 08690
    572 Monmouth Medical Center Southern Campus Lakewood New Jersey United States 08701
    573 Monmouth Medical Center Long Branch New Jersey United States 07740
    574 Memorial Sloan Kettering Monmouth Middletown New Jersey United States 07748
    575 Memorial Sloan Kettering Bergen Montvale New Jersey United States 07645
    576 Rutgers Cancer Institute of New Jersey New Brunswick New Jersey United States 08903
    577 The Valley Hospital-Luckow Pavilion Paramus New Jersey United States 07652
    578 Neurosurgeons of New Jersey-Ridgewood Ridgewood New Jersey United States 07450
    579 Valley Hospital Ridgewood New Jersey United States 07450
    580 Robert Wood Johnson University Hospital Somerset Somerville New Jersey United States 08876
    581 Valley Medical Group - Wayne Multispecialty Practice Wayne New Jersey United States 07470
    582 Valley Health System-Hematology/Oncology Westwood New Jersey United States 07675
    583 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    584 Southwest Gynecologic Oncology Associates Inc Albuquerque New Mexico United States 87106
    585 Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho New Mexico United States 87124
    586 Women's Cancer Care Associates LLC Albany New York United States 12208
    587 Montefiore Medical Center-Einstein Campus Bronx New York United States 10461
    588 Montefiore Medical Center-Weiler Hospital Bronx New York United States 10461
    589 Montefiore Medical Center - Moses Campus Bronx New York United States 10467
    590 Roswell Park Cancer Institute Buffalo New York United States 14263
    591 Memorial Sloan Kettering Commack Commack New York United States 11725
    592 Memorial Sloan Kettering Westchester Harrison New York United States 10604
    593 Northwell Health/Center for Advanced Medicine Lake Success New York United States 11042
    594 Mount Sinai Chelsea New York New York United States 10011
    595 Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York United States 10016
    596 Lenox Hill Hospital New York New York United States 10021
    597 Mount Sinai Hospital New York New York United States 10029
    598 Manhattan Eye Ear and Throat Hospital New York New York United States 10065
    599 Memorial Sloan Kettering Cancer Center New York New York United States 10065
    600 University of Rochester Rochester New York United States 14642
    601 State University of New York Upstate Medical University Syracuse New York United States 13210
    602 SUNY Upstate Medical Center-Community Campus Syracuse New York United States 13215
    603 Memorial Sloan Kettering Nassau Uniondale New York United States 11553
    604 Dickstein Cancer Treatment Center White Plains New York United States 10601
    605 Randolph Hospital Asheboro North Carolina United States 27203
    606 Hope Women's Cancer Centers-Asheville Asheville North Carolina United States 28816
    607 Cone Health Cancer Center at Alamance Regional Burlington North Carolina United States 27215
    608 UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina United States 27599
    609 Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina United States 28203
    610 Novant Health Presbyterian Medical Center Charlotte North Carolina United States 28204
    611 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    612 Atrium Health Cabarrus/LCI-Concord Concord North Carolina United States 28025
    613 Duke University Medical Center Durham North Carolina United States 27710
    614 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    615 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    616 Cone Health Cancer Center Greensboro North Carolina United States 27403
    617 Margaret R Pardee Memorial Hospital Hendersonville North Carolina United States 28791
    618 Novant Health Presbyterian Medical Center Huntersville Huntersville North Carolina United States 28078
    619 Onslow Memorial Hospital Jacksonville North Carolina United States 28546
    620 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    621 Novant Health Cancer Institute - Kernersville Kernersville North Carolina United States 27284
    622 Cone Heath Cancer Center at Mebane Mebane North Carolina United States 27302
    623 Novant Health Cancer Institute - Mount Airy Mount Airy North Carolina United States 27030
    624 Duke Raleigh Hospital Raleigh North Carolina United States 27609
    625 Annie Penn Memorial Hospital Reidsville North Carolina United States 27320
    626 Novant Health Cancer Institute - Statesville Statesville North Carolina United States 28625
    627 Novant Health Cancer Institute - Thomasville Thomasville North Carolina United States 27360
    628 Novant Health Cancer Institute - Wilkesboro Wilkesboro North Carolina United States 28659
    629 New Hanover Regional Medical Center/Zimmer Cancer Center Wilmington North Carolina United States 28401
    630 Novant Health Forsyth Medical Center Winston-Salem North Carolina United States 27103
    631 Novant Health Oncology Specialists Winston-Salem North Carolina United States 27103
    632 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    633 Sanford South University Medical Center Fargo North Dakota United States 58103
    634 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    635 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    636 Aultman Alliance Community Hospital Alliance Ohio United States 44601
    637 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
    638 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    639 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    640 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    641 Aultman Health Foundation Canton Ohio United States 44710
    642 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    643 Miami Valley Hospital South Centerville Ohio United States 45459
    644 Geauga Hospital Chardon Ohio United States 44024
    645 Adena Regional Medical Center Chillicothe Ohio United States 45601
    646 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    647 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    648 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    649 Bethesda North Hospital Cincinnati Ohio United States 45242
    650 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    651 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    652 Case Western Reserve University Cleveland Ohio United States 44106
    653 MetroHealth Medical Center Cleveland Ohio United States 44109
    654 Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio United States 44111
    655 Cleveland Clinic Foundation Cleveland Ohio United States 44195
    656 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    657 Mount Carmel East Hospital Columbus Ohio United States 43213
    658 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    659 Riverside Methodist Hospital Columbus Ohio United States 43214
    660 Grant Medical Center Columbus Ohio United States 43215
    661 The Mark H Zangmeister Center Columbus Ohio United States 43219
    662 Mount Carmel Health Center West Columbus Ohio United States 43222
    663 Doctors Hospital Columbus Ohio United States 43228
    664 Grandview Hospital Dayton Ohio United States 45405
    665 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    666 Miami Valley Hospital Dayton Ohio United States 45409
    667 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    668 Miami Valley Hospital North Dayton Ohio United States 45415
    669 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    670 Delaware Radiation Oncology Delaware Ohio United States 43015
    671 Grady Memorial Hospital Delaware Ohio United States 43015
    672 Dublin Methodist Hospital Dublin Ohio United States 43016
    673 Mercy Cancer Center-Elyria Elyria Ohio United States 44035
    674 Armes Family Cancer Center Findlay Ohio United States 45840
    675 Blanchard Valley Hospital Findlay Ohio United States 45840
    676 Orion Cancer Care Findlay Ohio United States 45840
    677 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    678 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    679 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    680 Wayne Hospital Greenville Ohio United States 45331
    681 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    682 Greater Dayton Cancer Center Kettering Ohio United States 45409
    683 First Dayton Cancer Care Kettering Ohio United States 45420
    684 Kettering Medical Center Kettering Ohio United States 45429
    685 Fairfield Medical Center Lancaster Ohio United States 43130
    686 Saint Rita's Medical Center Lima Ohio United States 45801
    687 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    688 Marietta Memorial Hospital Marietta Ohio United States 45750
    689 OhioHealth Marion General Hospital Marion Ohio United States 43302
    690 Hillcrest Hospital Cancer Center Mayfield Heights Ohio United States 44124
    691 UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio United States 44060
    692 UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights Ohio United States 44130
    693 Knox Community Hospital Mount Vernon Ohio United States 43050
    694 Licking Memorial Hospital Newark Ohio United States 43055
    695 Newark Radiation Oncology Newark Ohio United States 43055
    696 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    697 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    698 UH Seidman Cancer Center at Firelands Regional Medical Center Sandusky Ohio United States 44870
    699 Springfield Regional Cancer Center Springfield Ohio United States 45504
    700 Springfield Regional Medical Center Springfield Ohio United States 45505
    701 ProMedica Flower Hospital Sylvania Ohio United States 43560
    702 ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo Ohio United States 43606
    703 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    704 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    705 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    706 Upper Valley Medical Center Troy Ohio United States 45373
    707 University Hospitals Sharon Health Center Wadsworth Ohio United States 44281
    708 Saint Joseph Warren Hospital Warren Ohio United States 44484
    709 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    710 Saint Ann's Hospital Westerville Ohio United States 43081
    711 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    712 UHHS-Westlake Medical Center Westlake Ohio United States 44145
    713 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    714 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    715 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    716 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    717 Cancer Treatment Centers of America Tulsa Oklahoma United States 74133
    718 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    719 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    720 Saint Charles Health System Bend Oregon United States 97701
    721 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    722 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    723 Bay Area Hospital Coos Bay Oregon United States 97420
    724 Legacy Mount Hood Medical Center Gresham Oregon United States 97030
    725 Providence Newberg Medical Center Newberg Oregon United States 97132
    726 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    727 Legacy Good Samaritan Hospital and Medical Center Portland Oregon United States 97210
    728 Providence Portland Medical Center Portland Oregon United States 97213
    729 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    730 Legacy Meridian Park Hospital Tualatin Oregon United States 97062
    731 Jefferson Abington Hospital Abington Pennsylvania United States 19001
    732 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    733 Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania United States 18015
    734 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    735 Bryn Mawr Hospital Bryn Mawr Pennsylvania United States 19010
    736 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    737 Chambersburg Hospital Chambersburg Pennsylvania United States 17201
    738 Main Line Health Center-Collegeville Collegeville Pennsylvania United States 19426
    739 Geisinger Medical Center Danville Pennsylvania United States 17822
    740 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    741 Ephrata Cancer Center Ephrata Pennsylvania United States 17522
    742 Main Line Health Center-Exton Exton Pennsylvania United States 19341
    743 Adams Cancer Center Gettysburg Pennsylvania United States 17325
    744 Cherry Tree Cancer Center Hanover Pennsylvania United States 17331
    745 UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania United States 17109
    746 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    747 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    748 Jefferson Hospital Jefferson Hills Pennsylvania United States 15025
    749 Lancaster General Ann B Barshinger Cancer Institute Lancaster Pennsylvania United States 17601
    750 Lancaster General Hospital Lancaster Pennsylvania United States 17602
    751 Sechler Family Cancer Center Lebanon Pennsylvania United States 17042
    752 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    753 Lewistown Hospital Lewistown Pennsylvania United States 17044
    754 Riddle Memorial Hospital Media Pennsylvania United States 19063
    755 Forbes Hospital Monroeville Pennsylvania United States 15146
    756 Medical Center Clinic-New Castle Office New Castle Pennsylvania United States 16105
    757 Paoli Memorial Hospital Paoli Pennsylvania United States 19301
    758 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    759 Thomas Jefferson University Hospital Philadelphia Pennsylvania United States 19107
    760 Allegheny General Hospital Pittsburgh Pennsylvania United States 15212
    761 West Penn Hospital Pittsburgh Pennsylvania United States 15224
    762 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania United States 15232
    763 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    764 Community Medical Center Scranton Pennsylvania United States 18510
    765 Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania United States 17870
    766 Geisinger Medical Group State College Pennsylvania United States 16801
    767 Chester County Hospital West Chester Pennsylvania United States 19380
    768 Reading Hospital West Reading Pennsylvania United States 19611
    769 Wexford Health and Wellness Pavilion Wexford Pennsylvania United States 15090
    770 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    771 Asplundh Cancer Pavilion Willow Grove Pennsylvania United States 19090
    772 Lankenau Medical Center Wynnewood Pennsylvania United States 19096
    773 WellSpan Health-York Cancer Center York Pennsylvania United States 17403
    774 WellSpan Health-York Hospital York Pennsylvania United States 17403
    775 Women and Infants Hospital Providence Rhode Island United States 02905
    776 AnMed Health Cancer Center Anderson South Carolina United States 29621
    777 Medical University of South Carolina Charleston South Carolina United States 29425
    778 Gibbs Cancer Center-Gaffney Gaffney South Carolina United States 29341
    779 Saint Francis Hospital Greenville South Carolina United States 29601
    780 Saint Francis Cancer Center Greenville South Carolina United States 29607
    781 Gibbs Cancer Center-Pelham Greer South Carolina United States 29651
    782 Spartanburg Medical Center Spartanburg South Carolina United States 29303
    783 MGC Hematology Oncology-Union Union South Carolina United States 29379
    784 Rapid City Regional Hospital Rapid City South Dakota United States 57701
    785 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    786 Avera Cancer Institute Sioux Falls South Dakota United States 57105
    787 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    788 Bristol Regional Medical Center Bristol Tennessee United States 37620
    789 Memorial Hospital Chattanooga Tennessee United States 37404
    790 Vanderbilt-Ingram Cancer Center Cool Springs Franklin Tennessee United States 37067
    791 Pulmonary Medicine Center of Chattanooga-Hixson Hixson Tennessee United States 37343
    792 Wellmont Medical Associates Oncology and Hematology-Johnson City Johnson City Tennessee United States 37604
    793 Ballad Health Cancer Care - Kingsport Kingsport Tennessee United States 37660
    794 Wellmont Holston Valley Hospital and Medical Center Kingsport Tennessee United States 37660
    795 Thompson Cancer Survival Center Knoxville Tennessee United States 37916
    796 Thompson Cancer Survival Center - West Knoxville Tennessee United States 37932
    797 Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee United States 37204
    798 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    799 Thompson Oncology Group-Oak Ridge Oak Ridge Tennessee United States 37830
    800 Memorial GYN Plus Ooltewah Tennessee United States 37363
    801 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    802 Parkland Memorial Hospital Dallas Texas United States 75235
    803 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    804 UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas United States 76104
    805 Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas United States 77030
    806 Ben Taub General Hospital Houston Texas United States 77030
    807 Houston Methodist Hospital Houston Texas United States 77030
    808 Methodist Willowbrook Hospital Houston Texas United States 77070
    809 Houston Methodist West Hospital Houston Texas United States 77094
    810 Houston Methodist Sugar Land Hospital Sugar Land Texas United States 77479
    811 Houston Methodist The Woodlands Hospital The Woodlands Texas United States 77385
    812 Wellmont Medical Associates-Bristol Bristol Virginia United States 24201
    813 Kaiser Permanente-Burke Medical Center Burke Virginia United States 22015
    814 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    815 Inova Schar Cancer Institute Fairfax Virginia United States 22031
    816 Inova Fairfax Hospital Falls Church Virginia United States 22042
    817 Kaiser Permanente Tysons Corner Medical Center McLean Virginia United States 22102
    818 Southwest VA Regional Cancer Center Norton Virginia United States 24273
    819 Virginia Gynecologic Oncology Richmond Virginia United States 23229
    820 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    821 Carilion Clinic Gynecological Oncology Roanoke Virginia United States 24016
    822 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    823 MultiCare Auburn Medical Center Auburn Washington United States 98001
    824 Virginia Mason Bainbridge Island Medical Center Bainbridge Island Washington United States 98110
    825 Overlake Medical Center Bellevue Washington United States 98004
    826 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    827 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    828 Harrison Medical Center Bremerton Washington United States 98310
    829 Highline Medical Center-Main Campus Burien Washington United States 98166
    830 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    831 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    832 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    833 Providence Regional Cancer Partnership Everett Washington United States 98201
    834 Virginia Mason Federal Way Medical Center Federal Way Washington United States 98002
    835 Saint Francis Hospital Federal Way Washington United States 98003
    836 Tacoma/Valley Radiation Oncology Centers-Gig Harbor Gig Harbor Washington United States 98332
    837 MultiCare Gig Harbor Medical Park Gig Harbor Washington United States 98335
    838 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    839 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    840 Northwest Cancer Clinic Kennewick Washington United States 99336
    841 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    842 Saint Clare Hospital Lakewood Washington United States 98499
    843 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    844 Virginia Mason Lynnwood Medical Center Lynnwood Washington United States 98036
    845 Jefferson Healthcare Port Townsend Washington United States 98368
    846 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    847 Peninsula Cancer Center Poulsbo Washington United States 98370
    848 MultiCare Good Samaritan Hospital Puyallup Washington United States 98372
    849 Tacoma/Valley Radiation Oncology Centers-Puyallup Puyallup Washington United States 98372
    850 Valley Medical Center Renton Washington United States 98055
    851 Virginia Mason Medical Center Seattle Washington United States 98101
    852 Pacific Gynecology Specialists Seattle Washington United States 98104
    853 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    854 Fred Hutchinson Cancer Research Center Seattle Washington United States 98109
    855 Seattle Cancer Care Alliance Seattle Washington United States 98109
    856 Kaiser Permanente Washington Seattle Washington United States 98112
    857 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    858 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    859 University of Washington Medical Center - Montlake Seattle Washington United States 98195
    860 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    861 MultiCare Deaconess Cancer and Blood Specialty Center - Valley Spokane Valley Washington United States 99216
    862 MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane Washington United States 99204
    863 MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane Washington United States 99218
    864 Tacoma/Valley Radiation Oncology Centers-Jackson Hall Tacoma Washington United States 97405
    865 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    866 MultiCare Tacoma General Hospital Tacoma Washington United States 98405
    867 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    868 Tacoma/Valley Radiation Oncology Centers-Saint Joe's Tacoma Washington United States 98405
    869 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    870 Legacy Salmon Creek Hospital Vancouver Washington United States 98686
    871 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    872 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    873 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    874 United Hospital Center Bridgeport West Virginia United States 26330
    875 West Virginia University Charleston Division Charleston West Virginia United States 25304
    876 WVUH-Berkely Medical Center Martinsburg West Virginia United States 25401
    877 Monongalia Hospital Morgantown West Virginia United States 26505
    878 West Virginia University Healthcare Morgantown West Virginia United States 26506
    879 Camden Clark Medical Center Parkersburg West Virginia United States 26101
    880 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    881 Marshfield Clinic-Chippewa Center Chippewa Falls Wisconsin United States 54729
    882 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    883 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    884 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    885 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    886 Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin United States 54301
    887 Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin United States 54303
    888 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    889 Mercyhealth Hospital and Cancer Center - Janesville Janesville Wisconsin United States 53548
    890 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    891 Marshfield Clinic - Ladysmith Center Ladysmith Wisconsin United States 54848
    892 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    893 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    894 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    895 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    896 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    897 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    898 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    899 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    900 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    901 Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin United States 54154
    902 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    903 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    904 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    905 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    906 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    907 Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin United States 54235-1495
    908 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    909 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    910 Marshfield Clinic-Wausau Center Wausau Wisconsin United States 54401
    911 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    912 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    913 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    914 Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin United States 54494
    915 Cheyenne Regional Medical Center-West Cheyenne Wyoming United States 82001
    916 Billings Clinic-Cody Cody Wyoming United States 82414
    917 Welch Cancer Center Sheridan Wyoming United States 82801
    918 Advance Oncology Center Aguadilla Puerto Rico 00603
    919 Doctor's Cancer Center-Arecibo Arecibo Puerto Rico 00614
    920 Cancer Center-Metro Medical Center Bayamon Bayamon Puerto Rico 00959-5060
    921 Hematologia Oncologia San Pablo Bayamon Puerto Rico 00961
    922 HIMA San Pablo Oncologic Hospital Caguas Puerto Rico 00726
    923 Doctors Cancer Center Manati Puerto Rico 00674
    924 Instituto Oncologia Moderna Ponce Ponce Puerto Rico 00716
    925 San Juan Community Oncology Group San Juan Puerto Rico 00917
    926 Primary Care Physician Group San Juan Puerto Rico 00920
    927 Centro Comprensivo de Cancer de UPR San Juan Puerto Rico 00927
    928 San Juan City Hospital San Juan Puerto Rico 00936
    929 Centro de Hematologia y Oncologia del Sur Santa Isabel Puerto Rico 00757

    Sponsors and Collaborators

    • National Cancer Institute (NCI)
    • NRG Oncology

    Investigators

    • Principal Investigator: Roisin E O'Cearbhaill, NRG Oncology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT02839707
    Other Study ID Numbers:
    • NCI-2016-01081
    • NCI-2016-01081
    • NRG-GY009
    • NRG-GY009
    • NRG-GY009
    • U10CA180868
    First Posted:
    Jul 21, 2016
    Last Update Posted:
    Jul 25, 2022
    Last Verified:
    Apr 1, 2022

    Study Results

    No Results Posted as of Jul 25, 2022