Efficacy of EMDR Therapy, as Compared to Treatment as Usual, in Reducing Clinical Symptoms in People With HIV
Study Details
Study Description
Brief Summary
People living with HIV may suffer HIV-related psychological trauma. Studies also show that this group is vulnerable to non-HIV-related trauma. Trauma can increase vulnerability to stress and reducing the ability to cope. It can have a negative impact on treatment adherence, treatment outcomes, functioning and health-related quality of life. However, despite evidence showing psychological trauma can contribute to poor outcomes in HIV, little research has been carried out to assess whether psychological trauma-focused therapy can help people living with HIV.
A first-line treatment for psychological trauma is Eye Movement Desensitization and Reprocessing (EMDR) therapy. This therapy is recommended by the World Health Organization for treating Post-Traumatic Stress Disorder, with many studies showing this treatment is safe and effective for this disorder. However, it has not to our knowledge been specifically tested in the population of people living with HIV. This project will test whether EMDR therapy, in addition to the standard medical treatment received at the Infectious Diseases Unit, is more effective than standard medical treatment alone in reducing psychological trauma, improving health-related quality of life and improving HIV outcomes in people recently diagnosed with HIV. To test this, the investigators will recruit 40 people who have received a diagnosis of HIV within the last month. 20 will be offered the possibility to receive EMDR treatment for one hour weekly for up to 6 months, in addition to the standard medical treatment, while the other 20 will be offered only the standard medical treatment. The hypotheses of the present study are that the participants who receive EMDR therapy on top of their standard medical treatment will show a reduction in psychological trauma and related symptoms such as anxiety, depression and global distress, as compared to those who did not. The investigators also predict that the EMDR group will show improved functioning and health-related quality of life. The final hypotheses are that the EMDR group will show improved treatment adherence and HIV outcomes. If this study shows that a psychological trauma-focused therapy can help people adjust to a recent HIV diagnosis and have better outcomes, this will have important implications for improving care for people living with HIV.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Background
The seropositive population are vulnerable to high rates of psychological trauma with 30-40% of people living with HIV having HIV-related trauma, and rates of up to 90% of trauma unrelated to HIV. HIV-related trauma is linked to various events such as receiving the diagnosis, the number of medical symptoms, receiving treatment, the level of perceived stigma related to HIV, and witnessing HIV-related deaths. The risk of suffering trauma related to HIV is higher in those with prior trauma and negative life event.
Trauma is known to not only have a serious impact on mental health, but also to be a key predictor of poor prognosis in HIV, affecting treatment outcomes and health-related quality of life. Trauma exposure and the development of trauma symptoms impair psychosocial functioning, increase vulnerability to stress and burden the physiological systems involved in coping and adaptation. Patients with posttraumatic symptoms show poorer treatment adherence, yet even in therapy-adherent individuals, posttraumatic symptoms are associated with immune dysregulation, leading to decreased CD4 cell count and thus negative health outcomes. Trauma-affected patients are also more likely to engage in risky health-related behaviors and to suffer higher functional impairment not explained by CD4 count variance.
Due to the negative impact of trauma in terms of psychological distress and poorer HIV outcomes, psychological interventions which specifically address trauma are needed as an adjunct to antiretroviral treatment, in order to reduce unnecessary mortality related to poor treatment adherence and to improve health-related quality of life and functionality. There is even potential for psychological interventions to impact directly on HIV disease progression. Limited evidence suggests that psychological interventions targeting trauma can have a positive impact on HIV symptom experience, while a small but promising body of research into Mindfulness-based interventions targeted at reducing stress show they may have a positive impact on the biological HIV marker CD4. Therefore, a brief yet effective psychological intervention at the point of diagnosis could have a significant impact in reducing psychological trauma and distress and improving treatment adherence and thus prognosis, and may even improve HIV disease progression.
One of the first-line treatments for trauma in non-HIV populations is Eye Movement Desensitization and Reprocessing (EMDR) therapy. EMDR is a psychotherapeutic approach developed in the late 80s by Francine Shapiro that aims to treat traumatic memories and their associated stress symptoms. This therapy consists of a standard protocol which includes eight phases and bilateral stimulation (usually horizontal saccadic eye movements) to desensitize the discomfort caused by traumatic memories and the aim of the therapy is to achieve their reprocessing and integration within the patient's standard biographical memories. EMDR therapy is recommended by the World Health Organization as a psychotherapy of choice in the treatment of PTSD, showing efficacy in children, teenagers, and adults. Recent studies show potential for EMDR as an efficacious treatment in non-PTSD patients, including in promoting treatment adherence in bipolar patients and as an add-on treatment in chronic pain conditions, as per a recent review. Therefore, EMDR would seem to be indicated as an interesting therapeutic tool in helping people successfully assimilate the HIV diagnosis and reduce psychological distress and psychological trauma symptoms, and as an adjuvant treatment to health-related quality of life and potentially treatment adherence and biological markers of the disease.
This study aims to be the first to test the efficacy of the EMDR therapy in people recently diagnosed with HIV. If shown to be efficacious in this population, it could open the way for future studies to test the efficacy of EMDR in reducing risk behaviors associated with HIV transmission and as a treatment adjunct in treatment-refractory patients.
Evaluation & Diagnostic Protocol
In the baseline visit, sociodemographic data will be taken through a data collection notebook (CRD) and the validated Spanish versions of clinical scales, as well as scales related to health-related quality of life and functionality will be administered. At 6 months, the measures will be taken again, along with a measure regarding satisfaction of the treatment for participants in the EMDR group.
Side Effects and Follow Up
EMDR therapy is a safe and well tolerated psychological treatment. However, some may feel discomfort or suffer when the horizontal eye movements are carried out. If this occurs, bilateral stimulation will be achieved via tapping, which consists of small taps on the hands. Likewise, therapeutic work on difficult life experiences can accentuate psychological distress symptoms. The patient will be taught a variety of self-control techniques to be able to deal with the disturbing information which may arise during and between sessions. Any incident will be registered in the patient's clinical history as well as the CRD of the investigation project to later report the data.
Data Collection: Selection and Evaluation of Study Sample
Study participation is voluntary after being informed of the study objectives and having signed the informed consent document. The participants will be evaluated individually by specially trained health professionals (psychiatrists and psychologists qualified to make diagnoses). The project has been sent and approved to the Ethical Committee for Clinical Investigations in our Centre (number nº 2018/8199/I). Following the baseline evaluation, randomization will be carried out, stratified by age, sex and presence of prior trauma. Data will be collected post intervention. Motives for refusal to participate in the study will be collected to determine the presence of selection bias in the sample and the causes of non-participation.
Statistical Analysis
Calculation of Sample Size:
The study aims to evaluate the efficacy of the EMDR intervention protocol with TAU compared to TAU-only in terms of reduction of posttraumatic symptoms and psychological distress and an improvement in functionality, health-related quality of life, treatment adherence, and the biological markers of HIV of CD4 and the CD4/CD8 ratio. More specifically, the study will evaluate the efficacy of the EMDR therapy compared to treatment as usual in patients with HIV and psychological trauma in terms of clinical stabilization and improvement: reduction of associated trauma and affective symptoms, improvement of functioning, health-related quality of life and biological markers. This is a pilot study in order to get a signal whether or not this intervention is helpful with a planned sample size of 40. However, all patients meeting the inclusion criteria will be assigned to EMDR (n=20) or the TAU group (n=20) by two independent researchers using to the following algorithm: The first two patients will be randomly allocated to EMDR or TAU. For each subsequent patient, the treatment allocation will be identified, which a) balances the arm sizes if one arm has two patients more than the other arm, or otherwise b) decreases the largest effect-size of the between-arms differences in age, sex and trauma type. All steps of the randomization process will be automatically carried out in a central location using a computer program. Effect sizes will be estimated using Hedge's g, directly calculated in numeric variables and converted from odds ratios in binary variables.
Analysis of the main study variables
The distribution of the between-group socio-demographic and clinical characteristics at baseline will be analyzed using descriptive statistics. The continuous variables with a normal distribution will be analyzed with a Multivariate Analysis of Variance (MANOVA). The change in clinical and biological variables compared to baseline at strategic times during the intervention will be analyzed using an ANOVA with repeated measures including time factors, treatment conditions and their interaction. For cases which do not meet the normality premise, the Wilcoxon test will be used. The differences between groups, for the categorical and main clinical variables, will be analyzed using the Chi-squared test. Those variables which are statistically significant can be used as covariables in a logistical regression or lineal study of the factors associated with the significance of the effect, and to determine which variables are the best predictors of function. The effect size index will be estimated (Hedge's g or Pearson's r) for the correlation index of each analysis carried out. The statistical software used for all analyses will be the latest available version of SPSS (v. 24).
Analysis of Clinical Efficacy
For the main statistical analysis, the Intention to Treat (ITT) principal will be applied. The Last Observation Carried Forward (LOCF) will be used as the measure in cases of dropout.
Ethical Issues
The current Project will be carried out in accordance with the basic principles of protection of human rights and dignity as per the Helsinki Declaration and as per current legislation. The study will not begin until the Ethical Committee for Clinical Investigations (CEIC) gives approval and all information gathered will be treated confidentially, as per EU Regulation 2016/679. Patients will be informed verbally and need to sign the attached informed consent.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: EMDR plus TAU 20 individual weekly sessions of 60 minutes each of Eye Movement Desensitization and Reprocessing Therapy (EMDR), plus Treatment as Usual (TAU), applying first the standard EMDR protocol (Shapiro, 2005), and then a specific protocol for the sequelae of somatic illness and medical trauma (Hase, 2018). |
Behavioral: EMDR plus TAU
The standard EMDR protocol will first be applied, consisting of 8 phases: 1) Patient history; 2) Patient preparation; 3) Evaluation of the main aspects of the traumatic memory; 4) Desensitization of the memory; 5) Installation of the positive cognition; 6) Body scan; 7) Close and 8) Reevaluation. The specific protocol for the sequelae of somatic illness and medical trauma is next applied. It first focuses on processing past memories related to diagnosis, symptom development, medical procedures and unjust or stressful behaviour with the medical system. Once these are processed, the intervention addresses current symptoms, impairments and triggers. Finally, the patient is helped to face the future and reduce avoidance of medical procedures, avoidance of social life and fear of dying.
|
| No Intervention: TAU only The patients in this condition are newly diagnosed and will be introduced to the study in their first appointment with the Infectious Diseases Unit, in which analyses of HIV-related biological markers are taken. In a follow up appointment between 1 and 2 weeks later, antiretroviral treatment is initiated. There is a further check-up 1-2 months after initiating antiretroviral treatment, and then 6-monthly check-ups. In these checkups, measures of CD4 and the CD4/CD8 ratio are taken and treatment adherence is reviewed. The patients receiving EMDR therapy will also participate in these activities. |
Outcome Measures
Primary Outcome Measures
- Psychological trauma [From baseline to posttreatment at 6 months]
Psychological trauma will be evaluated using the Impact of Events Scale-Revised. This scale consists in 22-item to determine frequency and impact of posttraumatic symptoms experienced, with subscales of intrusion, avoidance and hyperarousal, each scored on a 5-point Likert scale, yielding a score for each subscale and a total score. This scale has a scoring range of 0 to 88. On this test, scores that exceed 24 can be quite meaningful. High scores have the following associations: 24 or more PTSD is a clinical concern. Those with scores this high who do not have full PTSD will have partial PTSD or at least some of the symptoms; 33 and above represents the best cutoff for a probable diagnosis of PTSD; 37 or more this is high enough to suppress your immune system's functioning (even 10 years after an impact event).
Secondary Outcome Measures
- Post-traumatic stress disorder [From baseline to posttreatment at 6 months]
Post-traumatic stress disorder will be assessed using the Global Post-traumatic Stress Evaluation-DSM V (EGEP-5). This scale consists a 58-item self-report checklist of posttraumatic symptoms to enable diagnosis as per DSM-V criteria. The items are separated in three sections: events (27 items), symptoms (28 items) and functioning (7 items). The scale has been designed to obtain information about: posttraumatic stress disorder (PTSD), intensity or severity of the posttraumatic symptoms (using scales), number of current posttraumatic symptoms, intensity or gravity of the subjective clinical symptoms, disorder specification (chronic or intense PTSD and its beginning), and the level of functional damage.
- Dissociative symptoms [From baseline to posttreatment at 6 months]
Dissociation will be evaluated using the Dissociative Experiences Scale (DES). This scale consists a 28-item self-report scale to identify the presence of 3 main symptom clusters of dissociation: amnesia, depersonalization and absorption. Scores are obtained for each subscale from 0 (occurring 0% of times) to 100 (occurring 100% of the time). There is also a global score and can be obtained by summing all the values of the items and dividing them by 28. The higher DES score means the more likely is that the patient has a dissociative disorder.
- Anxiety [From baseline to posttreatment at 6 months]
Anxiety will be assessed using the Generalized Anxiety Disorder-7 scale (GAD-7). This scales consists a 7-item self-administered scale to measure the severity of anxiety symptoms over the last 2 weeks and to screen between the anxiety disorders (Generalized Anxiety Disorder, Panic Disorder, Social Phobia and Post Traumatic Stress Disorder). Each item is scored on a 3-point Likert scale, with a cut-off score of 10 indicating clinical symptoms. The global score can be obtained by summing all the answers of the items. Higher scores correlate with disability and functional impairment.
- Depression [From baseline to posttreatment at 6 months]
Depression will be evaluated using the Patient Health Questionnaire-9 (PHQ-9). This scale consists a self-administered depression rating scale based on 9 items. Each of the items checked as positive have to be answered in a 3-point Likert scale. The global score can be obtained by summing all the answers of the items. The cut-off score of 10 indicates clinical symptoms (1-4 scores show minimal depression, 5-9 mild depression, 10-14 moderate depression, 15-19 moderately severe depression and 20-27 severe depression).
- General psychopathology [From baseline to posttreatment at 6 months]
General psychopathology will be assessed using the Brief Psychiatric Rating Scale (BPRS). This scale is used to assess the gravity and sub-classification (negative or positive) of the schizophrenic disorder. Each item is scored on a 7-point Likert scale, between 1 (symptom absence) and 7 (extremely severe). The total score is obtained summing the scores of each of the 18 items, ranging between 18 and 126. The score of the negative symptoms cluster is obtained by adding the scores of the following items: 3, 13, 16 and 18. This punctuation ranges between 4 and 28. The score of the positive symptoms cluster is obtained by adding the scores of the following items: 4, 11, 12 and 15. This punctuation also ranges between 4 and 28.
- Perception of quality of life [From baseline to posttreatment at 6 months]
Quality of life will be evaluated using the Medical Outcomes Study-Short Form 30 items (MOS-HIV 30). This scale consists a 35-item self-report in 11 domains to assess eleven dimensions of health including General Health Perceptions, Pain, Physical Functioning, Role Functioning, Social Functioning, Mental Health, Energy/Fatigue, Health Distress, Cognitive Function, Quality of Life and Health Transition. The raw scores for each scale are transformed to a 0-100 scale, with higher scores indicating a better quality of life and functioning.
- Treatment adherence [From baseline to posttreatment at 6 months]
Adherence to pharmacological treatment will be evaluated using the Morisky scale. The Morisky scale is designed to estimate the risk of medication non-adherence. Scores are based on patient responses to four, Yes or No questions. The total scores are ranked from 0 to 4, where the highest scores reflect greater medication adherence.
- CD4T and CD8T cells [From baseline to posttreatment at 6 months]
The average levels of CD4T and in the CD4T/CD8T index will be measured using blood samples.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Diagnosed with HIV within last 1 month
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Aged 18 - 65
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Impact of Events Scale-Revised score of higher than 0 related to HIV diagnosis
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Fluency in Spanish
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Initiating antiretroviral medication
Exclusion Criteria:
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Diagnosis of severe mental disorder or neurological disorder
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Current suicidal ideation
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Current substance use disorder
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Have received a structured therapy for trauma in the past 2 years (for part 2 of the study only)
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Clinical diagnosis of AIDS.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Parc de Salut Mar | Barcelona | Spain | 08019 |
Sponsors and Collaborators
- Parc de Salut Mar
- EMDR Europe
- Fundacion IMIM
Investigators
- Principal Investigator: Benedikt L Amann, PhD, Parc de Salut Mar; Fundación IMIM; Universitat Autónoma de Barcelona; CIBERSAM
Study Documents (Full-Text)
None provided.More Information
Publications
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- 2018/8199/I