Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

Sponsor
French Society for Intensive Care (Other)
Overall Status
Recruiting
CT.gov ID
NCT04304339
Collaborator
(none)
500
3
13
166.7
12.8

Study Details

Study Description

Brief Summary

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases.

Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results.

Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

Condition or Disease Intervention/Treatment Phase
  • Other: Hypercapnic respiratory failure

Study Design

Study Type:
Observational
Anticipated Enrollment :
500 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study
Actual Study Start Date :
Dec 14, 2021
Anticipated Primary Completion Date :
Dec 14, 2022
Anticipated Study Completion Date :
Jan 14, 2023

Outcome Measures

Primary Outcome Measures

  1. Prevalence of hypercapnic acute respiratory failure in ICU [Intensive Care Unit length stay (Usually 7 days)]

    Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • patients ≥18 years old presenting with at least of the following items :
  1. respiratory rate ≥ 25/min,

  2. paradoxical motion of the abdomen,

  3. intercostal retraction AND

  • a PaCO2 > 45 cm H20 before ICU admission or within the 12 hours following ICU admission.
Exclusion Criteria:
  • Refusal to give informed consent,

  • pregnancy,

  • < 18 years patient,

  • dying patient

Contacts and Locations

Locations

Site City State Country Postal Code
1 CH Andre Migniot Versailles A France
2 CHU Nantes Nantes France
3 CHU Toulouse Toulouse France

Sponsors and Collaborators

  • French Society for Intensive Care

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
French Society for Intensive Care
ClinicalTrials.gov Identifier:
NCT04304339
Other Study ID Numbers:
  • YETI
First Posted:
Mar 11, 2020
Last Update Posted:
Jan 6, 2022
Last Verified:
Dec 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jan 6, 2022