Retinal Vascular Manifestations in Patients With Common Internal Diseases on OCTA Tomography Angiography
Study Details
Study Description
Brief Summary
Hypertension, diabetes mellitus, and dyslipidemia are common internal diseases, and all diseases are atherosclerosis risk factors. Previous studies applied color fundus photography to analyze retinal vascular changes (including exudation, hemorrhage, neovascularization, etc.) in patients with hypertension or diabetes, but the examination results could not be quantified.
This study intends to apply optical coherence tomography angiography (OCTA) to examine retinal vessels. This method has the following advantages: 1) It can quantify vascular changes, and 2) It is noninvasive and reproducible for patients' follow-up.
This study was designed to investigate retinal vascular changes in patients with hypertension, diabetes, and dyslipidemia on OCTA. We will collect the patients' general information (gender, age), comorbidities, medications, blood lipids, blood glucose, carotid ultrasound, ankle-brachial index, ambulatory blood pressure monitoring, color fundus photography, and OCTA results. We will follow up with the patients for five years and conduct the mentioned examinations once a year. We will also investigate the correlation between systemic atherosclerosis (such as coronary artery stenosis, and carotid artery stenosis) and retinal vasculopathy in patients with these diseases.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Patients with hypertension, diabetes mellitus, or dyslipidemia, who go to the department of geriatric medicine, Beijing Tongren Hospital from March 2022 to December 2023 will be included. We will collect general information, comorbidities, medication, laboratory tests, and examination results. These patients will be followed up for 5 years with a yearly collection of comorbidities, medication, laboratory tests, and examination results.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Hypertension No intervention |
Other: No intervention
No intervention
|
| Diabetes mellitus No intervention |
Other: No intervention
No intervention
|
| Dyslipidemia No intervention |
Other: No intervention
No intervention
|
Outcome Measures
Primary Outcome Measures
- Vascular density of the retina [up to 5 years of follow-up.]
percent
Secondary Outcome Measures
- the foveal avascular zone (FAZ) size of the retina [When participating in the study, and once a year during 5 years of follow-up.]
mm2
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients with hypertension
-
Or patients with diabetes
-
Or patients with dyslipidemia
-
Agree to participate in this study
Exclusion Criteria:
-
Patients with malignant tumors
-
Patients with autoimmune diseases
-
Patients with immunodeficiency disease
-
Disagree to participate in this study
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Beijing Tongren Hospital | Beijing | Beijing | China |
Sponsors and Collaborators
- Beijing Tongren Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- YuHe2022