Effect of Preoperative High-dose Cholecalciferol in Prevention of Post-thyroidectomy Hypocalcaemia
Hypocalcaemia after thyroidectomy is observed with increasing frequency, often resulting in prolonged hospital stay with increased use of resources, delayed return to work and reduced quality of life. The administration of vitamin D is essential in the therapy of postoperative hypocalcaemia. What has not been examined so far is whether and how routine preoperative cholecalciferol prophylaxis can help to prevent postoperative hypocalcaemia
|Condition or Disease
Hypocalcemia following thyroid surgery is caused either due to parathyroid devascularization, stunning, or accidental removal of the parathyroid glandsMultiple risk factors have been identified which predispose patients to develop post-operative hypocalcemia. In light of the available evidence of prevalent vitamin D deficiency in the general population, and the observation of appearance of postthyroidectomy hypocalcemic symptoms at a much earlier stage than documented in previous literature, we postulate that a prophylactic vitamin D supplementation dose given in immediate preoperative period can significantly reduce acute symptomatic postoperative hypocalcemia in patients undergoing thyroid surgery
Arms and Interventions
|Experimental: Cholecalciferol group
patients will recieve one dose of Vitamin D 200000 IU PO at the time of admission
Dietary Supplement: Cholecalciferol
Cholecalciferol is vitamin D derivative and as our population already vit D deficient so post-operative hypocalcemia can be prevented.
|No Intervention: Control
Patients will not recieve any vitamin D before admission
Primary Outcome Measures
- Post-operative hypocalcemia [After 6 months]
The primary outcomes measure of this study was postoperative hypocalcemia based on either clinical symptoms or laboratory values.
Adult patients (> 18 years)
Scheduled for TT
Thyroid cancer treated with total thyroidectomy without lymph node dissection
Lack of written consent
Thyroid cancer treated with TT and lymph node dissection
Mediastinal goiter with need for sternotomy
Medication with thiazide diuretics, digitalis or lithium therapy
Previous neck operations or radiation
Chronic kidney failure.
Contacts and Locations
LocationsNo locations specified.
Sponsors and Collaborators
- Pak Emirates Military Hospital
- Principal Investigator: Mubashra Badar, Resident
Study Documents (Full-Text)None provided.
- Thy 1 cpsp