Effect of Preoperative High-dose Cholecalciferol in Prevention of Post-thyroidectomy Hypocalcaemia
Study Details
Study Description
Brief Summary
Hypocalcaemia after thyroidectomy is observed with increasing frequency, often resulting in prolonged hospital stay with increased use of resources, delayed return to work and reduced quality of life. The administration of vitamin D is essential in the therapy of postoperative hypocalcaemia. What has not been examined so far is whether and how routine preoperative cholecalciferol prophylaxis can help to prevent postoperative hypocalcaemia
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
Hypocalcemia following thyroid surgery is caused either due to parathyroid devascularization, stunning, or accidental removal of the parathyroid glandsMultiple risk factors have been identified which predispose patients to develop post-operative hypocalcemia. In light of the available evidence of prevalent vitamin D deficiency in the general population, and the observation of appearance of postthyroidectomy hypocalcemic symptoms at a much earlier stage than documented in previous literature, we postulate that a prophylactic vitamin D supplementation dose given in immediate preoperative period can significantly reduce acute symptomatic postoperative hypocalcemia in patients undergoing thyroid surgery
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Cholecalciferol group patients will recieve one dose of Vitamin D 200000 IU PO at the time of admission |
Dietary Supplement: Cholecalciferol
Cholecalciferol is vitamin D derivative and as our population already vit D deficient so post-operative hypocalcemia can be prevented.
Other Names:
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No Intervention: Control Patients will not recieve any vitamin D before admission |
Outcome Measures
Primary Outcome Measures
- Post-operative hypocalcemia [After 6 months]
The primary outcomes measure of this study was postoperative hypocalcemia based on either clinical symptoms or laboratory values.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Adult patients (> 18 years)
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Scheduled for TT
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Thyroid cancer treated with total thyroidectomy without lymph node dissection
Exclusion Criteria:
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Lack of written consent
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Thyroid cancer treated with TT and lymph node dissection
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Mediastinal goiter with need for sternotomy
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Medication with thiazide diuretics, digitalis or lithium therapy
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Previous neck operations or radiation
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Preexisting hyperparathyroidism
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Chronic kidney failure.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Pak Emirates Military Hospital
Investigators
- Principal Investigator: Mubashra Badar, Resident
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Thy 1 cpsp