Thyroxine Titration Study

Sponsor
Sir Charles Gairdner Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT00111735
Collaborator
(none)
55
Enrollment
1
Location
23
Duration (Months)
2.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of the study is to examine the effects of fine titration of thyroxine dosage on symptoms of hypothyroidism, wellbeing and quality of life. The hypothesis is that symptoms of hypothyroidism, wellbeing and quality of life will be improved in thyroxine-treated subjects when serum thyrotropin (TSH) is suppressed and/or in the lower reference range, compared to when TSH is in the upper reference range.

Condition or DiseaseIntervention/TreatmentPhase
Phase 4

Detailed Description

Primary hypothyroidism is a common disorder, affecting 2% of the Australian population. The standard treatment is with thyroxine (T4), and conventionally, a serum thyrotropin (TSH) concentration within the laboratory range is taken as indicating adequacy of thyroxine dosage.

Some patients with hypothyroidism complain of persistently impaired well-being, despite taking thyroxine in a dose which normalises serum TSH concentrations. It is not clear whether this is because of comorbidity or because standard thyroxine replacement is in some way inadequate for some individuals.

The reference range for serum TSH is wide (currently 0.34-4.8 mU/L at PathCentre). The distribution of serum TSH concentrations in the population is skewed, with the mean and median in the lower reference range at approximately 1.0 mU/L. This has led some to argue that a serum TSH in the lower reference range should be the usual therapeutic target. Anecdotal evidence suggests that some thyroxine-treated patients do feel better if the thyroxine dose is adjusted so that serum TSH is in the lower reference range rather than the upper reference range. The National Academy for Clinical Biochemistry of the United States now recommends, that for thyroxine-treated patients, that serum TSH should be less than 2.0 mU/L. There is, however, no evidence from properly conducted studies that aiming for a serum TSH concentration in the lower reference range improves symptoms of hypothyroidism or general wellbeing, and this proposal has not been generally adopted.

Only one study examining the effects of fine titration of thyroxine dosage on wellbeing has been published. In this study, patients had significantly improved wellbeing if they took a dose of thyroxine which was 50 μg greater than their biochemically optimal dose as determined by a thyrotropin-releasing hormone test. In most cases, serum TSH was suppressed to below 0.2 mU/L (the limit of sensitivity of the assay) on the thyroxine doses which improved wellbeing. This study was open-label and non-randomised, and the results therefore may have been affected by bias.

A well-designed, double blind study of the effects of fine titration of thyroxine dosage on symptoms of hypothyroidism, wellbeing and quality of life is required to determine if a serum TSH in the lower reference range, rather than simply TSH within the reference range, should indeed be the usual therapeutic target for thyroxine therapy in primary hypothyroidism. It is also desirable to confirm the findings of Carr et al., that patients have improved wellbeing if TSH is suppressed to below normal levels.

Study Design

Study Type:
Interventional
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Double
Primary Purpose:
Treatment
Official Title:
What is the Optimal Serum TSH Concentration During Thyroxine Treatment for Primary Hypothyroidism? Effects of Fine Titration of Thyroxine Dosage on Wellbeing, Quality of Life and Cognitive Function
Study Start Date :
Apr 1, 2003
Study Completion Date :
Mar 1, 2005

Outcome Measures

Primary Outcome Measures

  1. Visual analog scales assessing wellbeing []

Secondary Outcome Measures

  1. treatment satisfaction score []

  2. treatment preference []

  3. quality of life scores []

  4. cognitive function tests []

  5. clinical and biochemical markers of thyroid hormone action []

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Male or female subjects >18 years of age

  • Primary hypothyroidism ≥6 months duration arising from autoimmune hypothyroidism, thyroidectomy or radioiodine treatment

  • Thyroxine dose ≥100 mcg/day

  • No change in thyroxine dose in past 2 months

  • Serum TSH of 0.1-4.8 mU/L

  • Adequate contraceptive measures for women of childbearing age

Exclusion Criteria:
  • Major systemic illness affecting quality of life or likely to affect participation in the study

  • Treatment with T3 currently or in past 2 months

  • History of thyroid cancer requiring suppression of TSH secretion by thyroxine

  • Ischaemic heart disease - previous myocardial infarction, angina or coronary artery revascularisation

  • Renal failure: serum creatinine >135 micromol/L

  • Known liver disease with alkaline phosphatase or ALT >2x upper limit of reference range

  • Bony fracture in past 3 months or Paget's disease of bone

  • Secondary (central) hypothyroidism or hypopituitarism

Contacts and Locations

Locations

SiteCityStateCountryPostal Code
1Sir Charles Gairdner HospitalNedlandsWestern AustraliaAustralia6009

Sponsors and Collaborators

  • Sir Charles Gairdner Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
, ,
ClinicalTrials.gov Identifier:
NCT00111735
Other Study ID Numbers:
  • 2003-015
First Posted:
May 25, 2005
Last Update Posted:
Jun 24, 2005
Last Verified:
May 1, 2005
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jun 24, 2005