DiagMICI: Interest of GLP1 Analogues in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease

Sponsor
Groupe Hospitalier Paris Saint Joseph (Other)
Overall Status
Recruiting
CT.gov ID
NCT05196958
Collaborator
(none)
20
1
1
35.2
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Study Details

Study Description

Brief Summary

The risk of type 2 diabetes appears to be higher in patients with chronic inflammatory diseases, including chronic inflammatory bowel disease (IBD). IBD is a group of inflammatory diseases that includes mainly Crohn's disease and ulcerative colitis.

Although the majority of IBD patients are not overweight, the prevalence of obesity in this population remains significant, estimated at 15 to 40%. It has been shown that obesity can impact the response to therapies used in IBD as well as the clinical course of the disease:

  1. plasma concentrations of immunomodulatory therapies are often lower in the obese compared to those with a normal Body Mass Index (BMI) with a lower dose per kg of the administered drug as well as an acceleration of drug clearance.

2nd) Surgical management of IBD is associated with a higher risk of peri- and post-operative complications in obese patients, including an increase in operating time, bleeding risk, length of hospital stay and percentage of post-operative infections.

3e) Finally, obesity seems to have a negative impact on the clinical course of IBD, with a correlation between an increase in BMI and an increase in the number of hospitalizations, the number of follow-up consultations and the need for therapeutic escalation.

One of the common pathophysiological explanations between IBD and metabolic syndrome (including type 2 diabetes and obesity), would involve metabolites in the gut that are modulated by the gut microbiota.

Glucagon-Like Peptide 1 (aGLP1) analogues are a new class of injectable antidiabetic drugs that have revolutionized the management of type 2 diabetes. They include exenatide, lixisenatide, liraglutide, dulaglutide and semaglutide. They combine an effect on glycemic control but also usually a weight loss. In some countries, they are used in non-diabetic obese patients, with a weight loss of up to -10 to -15%. These molecules bind to GLP1 receptors, stimulate insulin secretion when blood glucose levels are high, decrease glucagon secretion, slow gastric emptying and stimulate satiety. In addition to glycemic control, weight reduction is most often associated.

In addition, some aGLP1s have been shown to reduce cardiovascular events in diabetics. They are well tolerated, but their side effects are mainly digestive, such as nausea, vomiting and sometimes diarrhea. These problems occur in about 20% of cases, most often after the first injection, with vomiting requiring permanent cessation of treatment. Most often they gradually subside, spontaneously or after symptomatic treatment, and allow titration of the drug.

Due to the lack of studies and possible intestinal effects, aGLP1 is not recommended in cases of severe gastrointestinal disease, and therefore in cases of IBD, although it is not contraindicated.

The main objective of this study is to test the interest of these GLP1 analogues in type 2 diabetics with IBD, who are overweight and whose glycemic target is not reached. The expected benefit is to facilitate diabetes control and weight loss in this population. The second objective is to monitor the occurrence of adverse events in this population with the different GLP1 analogues used.

Condition or Disease Intervention/Treatment Phase
  • Other: GLP1 analogues
N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
20 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Interest of GLP1 Analogues (aGLP1) in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease (IBD)
Actual Study Start Date :
Jan 25, 2022
Anticipated Primary Completion Date :
Jan 14, 2024
Anticipated Study Completion Date :
Dec 31, 2024

Arms and Interventions

Arm Intervention/Treatment
Experimental: GLP1 analogues

This cohort study has 2 phases: an observation phase to collect all initial clinical and biological parameters and an intervention phase (prescription of GLP1 analogues) of 6 months including a visit at 3 and 6 months.

Other: GLP1 analogues
This cohort study has 2 phases: an observation phase to collect all initial clinical and biological parameters and an intervention phase (prescription of GLP1 analogues) of 6 months including a visit at 3 and 6 months.

Outcome Measures

Primary Outcome Measures

  1. Glycemic control [Month 6]

    This outcome corresponds to the Change in HbA1c at 3 and 6 months compared with baseline at initiation of therapy.

  2. Weight loss [Month 6]

    This outcome corresponds to the weight reducation at 3 and 6 months compared to baseline.

Secondary Outcome Measures

  1. Tolerance of GLP1 analogues after 3 months of treatment [Month 3]

    This outcome corresponds to th number of serious and non-serious adverse events after 3 months of treatment with aGLP1.

  2. Tolerance of GLP1 analogues after 6 months of treatment tolerance of GLP1 analogues after 3 and 6 months of treatment [Month 6]

    This outcome corresponds to the number of serious and non-serious adverse events after 6 months of treatment with aGLP1.

  3. Quality of life after 3 months of treatment [Month 3]

    This outcome corresponds to the Quality of life of patients according to the Inflammatory Bowel Disease Questionnaire score. It includes 32 items in four domains: digestive symptoms (10 items), systemic symptoms (5 items), emotional disorders (12 items), social function (5 items). Each item is measured using the Likert technique. For each item, the interviewer presents a set of 7 statements describing an attitude. To each degree of agreement, a numerical value (from 1 to 7) is attached. In this way, by adding the individual scores, a total numerical value can be calculated. The total score ranges from 32 to 224, the higher the score the better the quality of life. This index has been validated and is correlated with the different disease activity scores.

  4. Quality of life after 6 months of treatment [Month 6]

    This outcome corresponds to the Quality of life of patients according to the Inflammatory Bowel Disease Questionnaire score. It includes 32 items in four domains: digestive symptoms (10 items), systemic symptoms (5 items), emotional disorders (12 items), social function (5 items). Each item is measured using the Likert technique. For each item, the interviewer presents a set of 7 statements describing an attitude. To each degree of agreement, a numerical value (from 1 to 7) is attached. In this way, by adding the individual scores, a total numerical value can be calculated. The total score ranges from 32 to 224, the higher the score the better the quality of life. This index has been validated and is correlated with the different disease activity scores.

  5. Impact of aGLP1 on the treatment already in place to regulate blood glucose [Month 6]

    This outcome corresponds to the reduction in number/dose of anti-diabetic medications or daily insulin dose.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 75 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
  • Patients between 18 and 75 years of age

  • Patients with inflammatory bowel disease (Crohn's disease (CD) or ulcerative colitis (UC))

  • Patient with poorly controlled type 2 diabetes (defined as deviation from the set glycemic target of more than 1% HbA1c)

  • Patient with a BMI ≥ 25 kg/m2

  • For women of childbearing age: effective contraception* during treatment and up to 5 weeks after discontinuation

  • Any contraceptive method used regularly and appropriately that has a low failure rate (i.e., less than 1% per year)
  • Patient enrolled in a health insurance plan

  • Francophone patient

  • Patient with free, informed, written consent

Exclusion Criteria:
  • Patient with a personal or family history of medullary thyroid cancer

  • Patient with an active cancer

  • Patient with a history of acute or chronic pancreatitis

  • Patients with a history of hypersensitivity to GLP1 analogues (or to any other component of the product)

  • Patient with a history of severe GI intolerance to GLP-1 receptor agonists

  • Patient already included in a risky interventional research protocol (RIPH1)

  • Pregnant or breastfeeding women

  • Patients with congestive heart failure New York Heart Association (NYHA) class IV

  • Patient with end-stage renal disease

  • Patients with clinically significant sustained elevation of resting heart rate

  • Patient with anti-GAD antibodies in a previous workup at inclusion

  • Patient under guardianship or curatorship

  • Patient under court protection

  • Patient deprived of liberty

Contacts and Locations

Locations

Site City State Country Postal Code
1 Groupe Hospitalier Paris Saint-Joseph Paris France 75014

Sponsors and Collaborators

  • Groupe Hospitalier Paris Saint Joseph

Investigators

  • Principal Investigator: Adela VOICAN, MD, Groupe Hospitalier Paris Saint Joseph

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Groupe Hospitalier Paris Saint Joseph
ClinicalTrials.gov Identifier:
NCT05196958
Other Study ID Numbers:
  • DiagMICI
First Posted:
Jan 19, 2022
Last Update Posted:
Jan 27, 2022
Last Verified:
Jan 1, 2022
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jan 27, 2022