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IPCoRV: Impact of Covid-19 on Rhinovirus Epidemic

Sponsor
Hospices Civils de Lyon (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05348707
Collaborator
(none)
400
Enrollment
12
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Rhinovirus (RV) has long been known as the main etiological agent of "common colds" among children and adults. Indeed, RV is involved in more than 50% of upper respiratory tract infections (URTIs), mostly characterized by nasal congestion, rhinorrhea, sore throat and cough. RV can also cause mild to severe lower respiratory tract infections (LRTIs) such as acute bronchiolitis, pneumonia and exacerbations of underlying chronic lung diseases. RV circulates worldwide, especially in temperate climate zones (i.e. many areas of the USA and Europe) and is responsible for annual outbreaks from early fall to the end of spring.

The covid-19 pandemic in 2020 seemed to interfere with the usual seasonal epidemics. For example, the winter Respiratory Syncytial Virus (RSV) epidemic in Lyon, France, was delayed for several months and reduced by half in terms of incidence of hospitalization cases. This can be explained by the widespread deployment of barrier gestures and social distancing measures, known as "non pharmacological interventions" (NPI).

However, the Covid-19 pandemic doesn't seem to have the same reducing impact on Rhinovirus epidemic. A better understanding of viral interactions and factors influencing RV epidemiology as well as the identification of populations at greater risk are required to improve preventive strategies and reduce the burden of Rhinovirus.

Condition or Disease Intervention/Treatment Phase
  • Other: epidemiology
  • Other: epidemiology

Study Design

Study Type:
Observational
Anticipated Enrollment :
400 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Impact of Covid-19 Pandemic on the Epidemiology of Rhinovirus
Anticipated Study Start Date :
May 1, 2022
Anticipated Primary Completion Date :
Apr 1, 2023
Anticipated Study Completion Date :
May 1, 2023

Arms and Interventions

Arm Intervention/Treatment
Pre Covid 19 cohort

Infants hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for Rhinovirus from 17th March 2019 to 16th March 2020.

Other: epidemiology
To review medical records to describe diagnosis and severity of the disease.
Other Names:
  • Medical record analysis

    • Other: epidemiology
    To compare pre and per Covid-19 epidemics in terms of numbers of admissions and proportion of severe disease.
    Other Names:
  • Comparison of cohorts

    		•
    Per Covid 19 cohort year 1

    Infant hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for Rhinovirus from 17th March 2020 to 16th March 2021. The need to recruit patients for an additional per-covid year (from 17th March 2021 to 16th March 2022) will be evaluated after the data from the first 2 years of recruitment are available.

    Other: epidemiology
    To review medical records to describe diagnosis and severity of the disease.
    Other Names:
  • Medical record analysis

    • Other: epidemiology
    To compare pre and per Covid-19 epidemics in terms of numbers of admissions and proportion of severe disease.
    Other Names:
  • Comparison of cohorts

    		•
    Per Covid 19 cohort, year 2

    Infants hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for Rhinovirus from 17th March 2021 to 16th March 2022. The need to recruit patients for this additional cohort will be evaluated after the data from the first 2 years of recruitment are available and analyzed.

    Other: epidemiology
    To review medical records to describe diagnosis and severity of the disease.
    Other Names:
  • Medical record analysis

    • Other: epidemiology
    To compare pre and per Covid-19 epidemics in terms of numbers of admissions and proportion of severe disease.
    Other Names:
  • Comparison of cohorts

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Evolution of the number of children hospitalized for a Rhinovirus-infection in the period of pre Covid-19 pandemic. [From one year before the SARS-CoV-2 pandemic until the beginning of the SARS-CoV-2 pandemic]

      Description of number of clinical picture cases for pre-SARS-CoV-2 pandemic year.

    2. Evolution of the number of children hospitalized for a Rhinovirus-infection in the period of per-Covid-19 pandemic. [From the beginning of the SARS-CoV-2 pandemic until one year latter]

      Description of number of clinical picture cases for per-SARS-CoV-2 pandemic year.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A to 1 Year
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
      • Child hospitalized at the " Hopital Femme Mere Enfant ", Lyon, France

    • Positive rhinovirus-PCR

    Exclusion Criteria:
      • parent's refusal to participate

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Hospices Civils de Lyon

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Hospices Civils de Lyon
    ClinicalTrials.gov Identifier:
    NCT05348707
    Other Study ID Numbers:
    • 502_2
    First Posted:
    Apr 27, 2022
    Last Update Posted:
    Apr 27, 2022
    Last Verified:
    Feb 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Hospices Civils de Lyon
    Rhinovirus epidemic
    SARS-CoV2/Rhinovirus interaction
    Children
    Non-pharmacological-interventions
    Bronchiolitis
    Asthma
    Pneumonia
    Fever
    Meningitis
    Rhinovirus infection in children less than 1 years of age

    Study Results

    No Results Posted as of Apr 27, 2022