Impact of Polymorphism on Pulmonary Pressure in Subjects With Pulmonary Hypertension of Different Cause
Study Details
Study Description
Brief Summary
Pulmonary Hypertension (PH) is a disease that is characterized by vasoconstriction of small vessels of the lung. Many cases do have proliferation of endothelial cells within these vessels. A possible influence of polymorphisms of genes relevant for inflammatory and endothelial processes is suspected.
Especially patients with chronic heart failure can develope PH. The reasons therefore are lacking.
The researchers investigate different polymorphism and the influence of these on pulmonary artery pressure (measured invasively) in patients with congestive heart failure (CHF) and patients with primary pulmonary hypertension.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
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Detailed Description
The study consists of 3 arms-patients with CHF and PH, patients with CHF without PH and patients without CHF and PH.
The PH measurement is due to routine catheterization, thereafter we measure different vasoactive polymorphism.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
CHF with elevated PAP CHF patients (LVEF > 35%) with elevated mean pulmonary pressure( > 20 mmHg ) measured by pa catheter |
|
CHF patient without elevated PAP CHF patients (LVEF > 35%) with normal mean pulmonary pressure |
|
Normal EF with elevated PAP Patients with normal LVEF < 60% with elevated mean pulmonary pressure |
Outcome Measures
Primary Outcome Measures
- Correlation of the Expression of Glu 298ASP Polymorphism with pulmonary pressure [Dec. 2010]
Secondary Outcome Measures
- Rate of G308A TNF alpha polymorphism within the different groups [Dec. 2010]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
CHF with or without pulmonary hypertension or
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patients with normal LVEF and pulmonary hypertension
-
right heart catheterization due to routine
-
informed consent
Exclusion Criteria:
-
no right heart catheterization
-
no informed consent
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elevated pulmonary pressure due to valve diseases or congenital heart disease
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Heart Center Leipzig- University Leipzig | Leipzig | Germany | 04289 |
Sponsors and Collaborators
- University of Leipzig
- Heart Center Leipzig - University Hospital
Investigators
- Principal Investigator: Sven Möbius-Winkler, M.D, University Leipzig-Heart Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SMW 03