AIDCO: Important Data on COVID-19 Profile in Africa

Sponsor

Centre de Recherche Médicale de Lambaréné (Other)

Overall Status

Completed

CT.gov ID

NCT04847817

Collaborator

European and Developing Countries Clinical Trials Partnership (EDCTP) (Other), Leiden University Medical Center (Other), Institut de recherche en santé de surveillance épidémiologique et de formation (Other), Université des Sciences de la Santé (Other), Armauer Hansen Research Institute, Ethiopia (Other), Universität Tübingen (Other)

574

Enrollment

Locations

Actual Duration (Months)

287

Patients Per Site

15.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to Understand the natural history of Coronavirus 2019 (COVID-19) infection to better define the period of infectiousness and transmissibility and to establish biobanks of COVID-19 blood and mucosal samples.

Condition or Disease	Intervention/Treatment	Phase
Coronavirus Infection Africa

Detailed Description

In this study ,the participants will be enrolled sequentially in the COVID-19 care referral centers. The infected hospitalized patient will be identified by the physicians in hospital. After the patient has given his/her informed consent the permission will be sought from him to approach his household contacts. The household contacts will be screened, and included in the study.

Patients hospitalized and positive for COVID-19 by PCR and their household contacts of all ages and gender (40% minimum of female), will be enrolled upon receipt of written informed consent.

Study Design

Study Type:

Observational

Actual Enrollment :

574 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Important Data on COVID-19 Profile in Africa

Actual Study Start Date :

Aug 1, 2020

Actual Primary Completion Date :

Dec 31, 2021

Actual Study Completion Date :

Mar 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Index cases Patients infected by SARS-Cov2 Polymerase Chain Reaction (PCR) and hospitalized in a referral center for COVID-19 .
Households cases Household contacts of SARS-Cov2 hospitalized COVID-19 patients.

Outcome Measures

Primary Outcome Measures

clinical and biological parameters of COVID-19 [14 days]
Infection and disease progression - Pattern of virus transmission
SARS-CoV-2 transmissibility [14 days]
proportion of household contact who will become positive for SARS-COV2 using PCR

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Inclusion Criteria:

Molecular (PCR) confirmed COVID-19 patients hospitalized in referral centers,
Household contacts of hospitalized COVID-19 patient,
Provided signed informed consent.

Exclusion Criteria:

Pregnancy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Centre de Recherches Médicales de Lammbaréné	Lambaréné	Moyen- Ogooué	Gabon	1437
2	Centre de Recherches Médicales de Lambréné	Lambaréne		Gabon

Sponsors and Collaborators

Centre de Recherche Médicale de Lambaréné
European and Developing Countries Clinical Trials Partnership (EDCTP)
Leiden University Medical Center
Institut de recherche en santé de surveillance épidémiologique et de formation
Université des Sciences de la Santé
Armauer Hansen Research Institute, Ethiopia
Universität Tübingen

Investigators

Principal Investigator: Ayôla Akim ADEGNIKA, Centre de Recherches Médicales de Lambaréné
Principal Investigator: Marielle BOUYOU-AKOTET, Université des Sciences de Santé