Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo
Study Details
Study Description
Brief Summary
This study examines melanoma and nonmelanoma skin cancer in people diagnosed with vitiligo compared to matched controls.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
For the primary analysis, this study examines the risk of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma in people diagnosed with vitiligo. It also examines actinic keratoses. In secondary analysis, this study examines the prevalence of skin cancer in people diagnosed with vitiligo compared to matched controls.
This study also examines whether the susceptibility to melanoma and nonmelanoma skin cancer may vary between different patient subgroups, e.g. ethnicity, those who undergo phototherapy or treatment with the new targeted biologic immunosuppressive therapies.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Cases Patients with a confirmed diagnosis of Vitiligo within the study period will be included as cases for analysis. |
Other: Exposure of skin cancer of interest
Melanoma and nonmelanoma skin cancers: squamous cell carcinoma, basal cell carcinoma and actinic keratoses.
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Controls The controls will be defined by matching cases with people who have never been diagnosed with vitiligo either prior to or during the study period, by age and sex, at General Practice level. |
Other: Exposure of skin cancer of interest
Melanoma and nonmelanoma skin cancers: squamous cell carcinoma, basal cell carcinoma and actinic keratoses.
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Outcome Measures
Primary Outcome Measures
- Risk of new onset skin cancer in adult people diagnosed with vitiligo [10 years from the index date]
Risk of new onset skin cancer assessed prospectively in vitiligo cases and matched controls. The skin cancer outcome comprises of the composite of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma.
- Risk of new onset skin cancer in adult people diagnosed with vitiligo by sociodemographic subgroups [10 years from the index date]
Risk of new onset skin cancer assessed prospectively in vitiligo cases and matched controls. Sociodemographic subgroups defined by age, sex, socioeconomic status and ethnicity.
Secondary Outcome Measures
- Prevalence of skin cancer in adult people diagnosed with vitiligo [At index date]
Skin cancer is defined as the composite of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma.
- Prevalence of individual skin cancers in adult people diagnosed with vitiligo [At index date.]
Melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma, and actinic keratoses.
Eligibility Criteria
Criteria
Inclusion Criteria:
- All eligible adult patients (aged ≥ 18) registered with General Practioner (GP) practices contributing data to OPCRD between January 1, 2010 and December 31, 2020, were eligible for inclusion in the study. People diagnosed with vitiligo prior to the study period (prevalent vitiligo) and people newly diagnosed with vitiligo during the study period (incident vitiligo) are included as cases.
Exclusion Criteria:
- People actively registered with the GP practice at that date without a history of vitiligo require a minimum one-year registration with their GP practice.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Momentum Data Ltd | London | United Kingdom | WC1X 8QT |
Sponsors and Collaborators
- Momentum Data
- Pfizer
Investigators
- Study Director: Andrew McGovern, MD, Momentum Data Ltd
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- P045