Vitamin D Supplementation in Vitamin Deficient Women Undergoing IVF Cycles: Does it Affect the Fertility Outcome?
Study Details
Study Description
Brief Summary
The aim of this study is to evaluate the effect of treatment of vitamin D deficiency (through vitamin D supplementation for 8 weeks before the start of In-vitro fertilization (IVF) on the success of IVF cycles.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 4 |
Detailed Description
The study participants are vitamin D deficient females undergoing (intra-cytoplasmic sperm injection (ICSI) trial in the age of 20 to 35 years. Serum vitamin D will be assessed. Accordingly, if they are deficient in vitamin D, they will be eligible for the study.400 vitamin D deficient women will be randomly allocated to either one of two groups. The first group will receive vitamin D supplementation in addition to the routine care. The other group will receive the routine care only. The study will be conducted in the IVF unit of department of Obstetrics and Gynecology, Cairo University.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Vitamin D supplement This group will receive weekly oral 50000 international units of vitamin D supplement for 8 weeks before the start of ICSI cycle. In addition, the routine care will be given. |
Drug: Vitamin D
Vitamin D supplement will be given. Then, it will be maintained if pregnancy occurred
Other Names:
|
No Intervention: Routine care This group will receive the routine care. |
Outcome Measures
Primary Outcome Measures
- Clinical pregnancy rate [It will be calculated 1 year after enrollment of the first patient in the study]
This outcome will be calculated by a statistician
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Vitamin D deficient females undergoing first ICSI trial
-
Age from 20 to 35 years
Exclusion Criteria:
- Women undergoing ICSI trials who are vitamin D sufficient
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Department of Obstetrics and Gynecology, Kasr Al-Ainy hospital | Cairo | Greater Cairo | Egypt | 11956 |
Sponsors and Collaborators
- Cairo University
Investigators
- Principal Investigator: Eman Omran, M.D., Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 3645