Cabergoline As An Adjuvant To Clomiphene Citrate For Management Of Unexplained Infertility
Study Details
Study Description
Brief Summary
Infertility refers to an inability to conceive after having regular unprotected sex. Infertility can also refer to the biological inability of an individual to contribute to conception, or to a female who cannot carry a pregnancy to full term. In many countries infertility refers to a couple that has failed to conceive after 12 months of regular sexual intercourse
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 2/Phase 3 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: study group will receive a dose of Clomiphene citrate 50 mg tablet , 1 tab twice daily for 5 days from the third day of menses to the seven day and cabergoline 0.25 mg (half tablet) every 3 days (one package) first three months then Clomiphene citrate 50 mg tablet , 2 tabs twice daily for 5 days from the third day of menses to the seven day and cabergoline 0.25 mg (half tablet) every 3 days (one package) |
Drug: Clomiphene Citrate 50mg
oral tablets
Drug: Cabergoline Oral Tablet
oral tablets
|
Active Comparator: control group will receive a dose of Clomiphene citrate and placebo tablets with same dose and duration |
Drug: Clomiphene Citrate 50mg
oral tablets
Drug: Placebo Oral Tablet
oral tablets
|
Outcome Measures
Primary Outcome Measures
- The number of mature follicles [14 days]
the follicles reach the size of 18 mm
Eligibility Criteria
Criteria
Inclusion Criteria:
-
unexplained infertility, Primary or secondary.
-
Absence of galactorrhoea.
-
Normal serum prolactin.
-
Normal hysterosalpingography.
-
Normal spermogram.
Exclusion Criteria:
-
Women on other line of treatment as aromatase inhibitors,gonadotrophins, or tamoxifen.
-
Known hypersensitivity for cabergoline or clomiphene citrate.
-
Other factors of infertility as tubal factor, uterine factor or male factor.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CabCC