GETSET: Preimplantation Genetic Testing in Women of Advanced Maternal Age
Study Details
Study Description
Brief Summary
The GETSET trial is a prospective randomized trial designed to evaluate the clinical outcomes of incorporating preimplantation genetic testing for aneuploidies (PGT-A) in elective single embryo transfer in women between 35 and 40 years of age.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
In this randomized controlled trial, a total of 240 patients divided evenly across the two participating IVF centers will be recruited. Patients will be randomized to a control and to a treatment group, each containing 120 participants.
Only patients with at least one evaluable blastocyst will be randomized. Patients will undergo ovarian hyper-stimulation, oocyte retrieval, fertilization and embryo culture per standard clinical protocol determined by IVF center.
In the control arm, patients will undergo a single frozen embryo transfer with an untested blastocyst with the best morphology. All other blastocysts with lower morphology will undergo trophectoderm biopsy on day 5, 6 or 7 and will be frozen. PGT-A results of the untransferred embryos will be revealed to the patient AFTER the outcome of the initial ET is known. If the initial transfer results in a non-conception cycle and additional euploid embryos are available for transfer, these cycles will be followed and their outcomes collected.
In the experimental arm, all embryos will be cultured to blastocyst and all viable blastocysts will undergo trophectoderm biopsy and PGT-A. PGT-A will be performed regardless of the number of blastocysts available. Patients will undergo frozen transfer of the single, best quality euploid blastocyst. If the initial transfer results in a non-conception cycle and additional embryos are available for transfer, these cycles will be followed and their outcomes collected until the embryo cohort is exhausted.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: PGT-A transfer Transfer of single chromosomally normal (euploid) blastocyst after PGT-A |
Procedure: Preimplantation genetic testing for aneuploidy (PGT-A)
24-chromosome screening for aneuploidy in the preimplantation embryo (blastocyst stage)
Other Names:
|
| No Intervention: Untested blastocyst transfer Transfer of single untested blastocyst based on embryo morphology criteria. |
Outcome Measures
Primary Outcome Measures
- Ongoing pregnancy rate [Up to 18 months]
Number of patients who experience an ongoing pregnancy rate (>20 weeks of gestation) after their first embryo transfer
Secondary Outcome Measures
- Miscarriage rate [Up to 18 months]
Number of patients who experience a miscarriage after their first embryo transfer
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Women undergoing IVF of between 35 and 40 years of age at IVF cycle start
-
Utilization of Intracytoplasmic Sperm Injection ICSI
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Utilization of ejaculated or testicular sperm
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Utilization of autologous or donor sperm
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All Controlled Ovarian Hyperstimulation (COH) protocols
Exclusion criteria:
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Patients with anovulatory Polycystic ovarian syndrome (PCOS)
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Utilization of donor oocytes
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Utilization of gestational carrier
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Recurrent Pregnancy Loss (RPL) defined as ≥ 3 consecutive miscarriages
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Recurrent Implantation Failure (RIF) defined as ≥ 3 more failed embryo transfers
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | IVF Florida Reproductive Associates | Margate | Florida | United States | 33063 |
Sponsors and Collaborators
- Genomic Prediction Inc.
Investigators
- Principal Investigator: Nathan R Treff, PhD, Genomic Prediction
Study Documents (Full-Text)
None provided.More Information
Publications
- Forman EJ, Hong KH, Ferry KM, Tao X, Taylor D, Levy B, Treff NR, Scott RT Jr. In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial. Fertil Steril. 2013 Jul;100(1):100-7.e1. doi: 10.1016/j.fertnstert.2013.02.056. Epub 2013 Mar 30.
- Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. Electronic address: ASRM@asrm.org; Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion. Fertil Steril. 2018 Mar;109(3):429-436. doi: 10.1016/j.fertnstert.2018.01.002. Review.
- Scott RT Jr, Upham KM, Forman EJ, Hong KH, Scott KL, Taylor D, Tao X, Treff NR. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial. Fertil Steril. 2013 Sep;100(3):697-703. doi: 10.1016/j.fertnstert.2013.04.035. Epub 2013 Jun 1.
- Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, Peck AC, Sills ES, Salem RD. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet. 2012 May 2;5(1):24. doi: 10.1186/1755-8166-5-24.
- Genomic Prediction Inc 624