Influencing Factors of Coronary Heart Disease in Young People

Sponsor

Hongzhuan Sheng (Other)

Overall Status

Recruiting

CT.gov ID

NCT05175495

Collaborator

Affiliated Hospital of Nantong University (Other)

1,000

Enrollment

Location

Anticipated Duration (Months)

27.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The incidence of coronary heart disease in young people is not uncommon and the investigators will explore the factors contributing to this outcome

Condition or Disease	Intervention/Treatment	Phase
Coronary Heart Disease

Detailed Description

Through the multi-center clinical research conducted by several units in Nantong city, the risk factors and aggregation of the incidence of CHD among young people in nantong city were obtained, so as to fill in the blank of domestic multi-center research and reduce the incidence of CHD among young people.The investigators will conduct a long-term follow-up study on the young patients with CHD to screen the factors contributing to the poor prognosis of CHD in young patients.The investigators will fill this gap and intervene early to improve patients' quality of life and prolong their survival

Study Design

Study Type:

Observational

Anticipated Enrollment :

1000 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

To Study the Risk Factors of Youth Coronary Heart Disease From Inflammatory Cytokines，Lifestyle and Familial Inheritance

Actual Study Start Date :

Aug 1, 2021

Anticipated Primary Completion Date :

Aug 1, 2024

Anticipated Study Completion Date :

Aug 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Normal young Aged less than 45 years old,no underlying heart disease
Young people diagnosed with coronary heart disease Aged less than 45 years old,Diagnosed coronary heart disease;Confirmed by coronary angiography;Diagnosed myocardial infarction;Typical symptom of ischemic chest pain with positive stress test;
Coronary heart disease Older than 65 years, diagnosed with coronary heart disease

Outcome Measures

Primary Outcome Measures

Whether inflammatory factors are differentially expressed in young patients with coronary heart disease [Until April 2024]
The Investigators will analyze blood samples from the participants to see if there was a difference in the expression of inflammatory factors with high correlation compared with the control group by ELESA and High-throughput sequencing.
The effect of gene activity on youth morbidity [Until April 2024]
The investigators will use enrichment analysis to screen the target genes and sequence the participants.Whether the target gene was expressed at high levels in the participants.And the investigators will further analyze the target gene
Sedentary, high-fat diet, lack of exercise and other unhealthy lifestyle effects on young people [Until April 2024]
The researchers will retrospectively examine the participants' negative lifestyle habits, such as sedentary behavior, smoking, high-fat diet, and lack of exercise, in combination with their coronary angiography results