Intermetatarsal Bursitis in Patients With Rheumatoid Arthritis
Study Details
Study Description
Brief Summary
The aim of the study is to investigate the incidence and clinical implications of intermetatarsal bursitis (IMB) in patients with rheumatoid arthritis (RA).
The hypothesis is that IMB is a cause of pain in patients with RA.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Within the recent years more research have focused on IMB in patients with rheumatologic disorders. There is emerging evidence that IMB is an inflammatory alteration in line with synovitis in patients with RA, and presence of IMB have been linked to the early stages of RA, especially due to the focus of the published literature.
The clinical implications of the presence of IMB for the patients are yet to be understood. Limited studies have linked the occurrence of IMB to foot impairment, but no studies have been conducted investigating the direct association between forefoot pain and the presence/absence of IMB.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Patient group Patients with rheumatoid arthritis and forefoot pain. |
Diagnostic Test: Magnetic resonance imaging
MRI scan with contrast of the foot or feet
Other Names:
Diagnostic Test: Ultrasound
Ultrasound scan of the feet
Other Names:
Drug: Corticosteroid injection
Administered ultrasound guided to patients with intermetatarsal bursitis
Other: Clinical foot evaluation
An examination of the feet
Other: Picture of the feet
To evaluate the presence of V-sign/spreading toes
|
| Other: Control group Patients with other rheumatic diseases and absence of forefoot pain. |
Diagnostic Test: Magnetic resonance imaging
MRI scan with contrast of the foot or feet
Other Names:
Diagnostic Test: Ultrasound
Ultrasound scan of the feet
Other Names:
Other: Picture of the feet
To evaluate the presence of V-sign/spreading toes
|
Outcome Measures
Primary Outcome Measures
- Incidence of intermetatarsal bursitis on MRI [8 weeks]
High intensity on T2 weighted images, low signal on T1. Thin peripheral enhancement on T1 contrast enhanced pictures.
- Incidence of intermetatarsal bursitis on US [8 weeks]
Hypoechoic mass between metatarsal heads. Activity on power/color doppler.
- Incidence of other pathology on MRI [8 weeks]
Other than intermetatarsal bursitis
- Incidence of other pathology on US [8 weeks]
Other than intermetatarsal bursitis
- Change in Visual Analogue Score (VAS) score [At inclusion, 1 and 3 month(s) post treatment]
Pain score related to the foot pain
Secondary Outcome Measures
- Incidence of opening toes [1 day]
Presence of opening toes/V-sign/spreading toes.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age > 18 years
-
Forefoot pain and diagnosed with RA (patient group)
-
Diagnosed with an axial arthritis (control group)
Exclusion Criteria:
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Age <18 years
-
Open wounds or ongoing infection in the forefoot at the time of examination
-
Persons with a history of significant trauma in the forefoot, e.g. any fracture or previous surgeries in the forefoot
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Persons who have previously received intermetatarsal treatment (Morton's neuroma or IMB) in the same foot, e.g. injection within 6 months or operation at any time
-
Exclusion from MRI scan only:
-
Persons with contraindications to participate in MRI scan
-
Persons with severely impaired renal function (GFR <30 ml/min)
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Rigshospitalet, Denmark
- The Danish Rheumatism Association
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- H-22033815